Q9C1W8

PR
Gene name
ppn1 (SPBC713.07c)
Protein name
Endopolyphosphatase
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC713.07c
EC number
3.6.1.10: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

405-485 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C1W8

Entry ID Method Resolution Chain Position Source
AF-Q9C1W8-F1 Predicted AlphaFoldDB

No variants for Q9C1W8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9C1W8

No associated diseases with Q9C1W8

2 regional properties for Q9C1W8

Type Name Position InterPro Accession
domain Calcineurin-like phosphoesterase domain, ApaH type 48 - 316 IPR004843
domain Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain 49 - 338 IPR041805

Functions

Description
EC Number 3.6.1.10 In phosphorus-containing anhydrides
Subcellular Localization
  • Vacuole membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
endopolyphosphatase activity Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.
exopolyphosphatase activity Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.

2 GO annotations of biological process

Name Definition
energy reserve metabolic process The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRPSVITVAV LFVQSTWASF AFGNPMSMRN KAHTNDLVNS KGKPLVGRFL HITDMHPDIY
70 80 90 100 110 120
YEKGSTVDHY CHSYDHNSDD TPLGKSKVGY LSPGPGYECD SSPALIDKTL EWLKEHQDDV
130 140 150 160 170 180
LGGIDFILWT GDNSRHDNDN HFPRTQSEIL ASNEDLVNKM IEAFPDVPIV SAIGNNDIYP
190 200 210 220 230 240
HNIMEAGPSS MTRQLAGAWD ALIPYEERHT FEKGSYYLCD VIPDKLAAIS INTLYLSNKN
250 260 270 280 290 300
AAVDGCPDDN LDEPGSLFMR WFKIQLEAYR LKGMKVWLLG HIPPTRGQWY EDCYTSFTDL
310 320 330 340 350 360
LYEFRDIIVG QLYGHMNINH FVFLEFDKLP VDTESYGIKS AQPKYVKSLI DAQYAELPTF
370 380 390 400 410 420
PENLTEEFLN GTVGNYSLAT VGGSIIPEMF PTFRVYEYNI SDIANQLDDR EELTEITSFN
430 440 450 460 470 480
WETLEEQSQS DYEIDKKKKK KKKNNKKKKK NKRKNIKPGP LGPAYVPSLF TPISFKQYFL
490 500 510 520 530 540
NTSNYMDATK DTEISYELLY TSKDSPYNMP DLTVPEYMRL AKRIATCDKP EDPHQFKLQS
550 560 570
GDQNTFRISK KKKPSICPIA YTYLWHAYIG SISDFED