Q9C100

PR
Gene name
ogm2 (oma2, SPAPB1E7.09)
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAPB1E7.09
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C100

Entry ID Method Resolution Chain Position Source
AF-Q9C100-F1 Predicted AlphaFoldDB

4 variants for Q9C100

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3314871_A_C 411 I>L No Jeffares_SNPs
I_3315223_A_G 528 E>G No Jeffares_SNPs
I_3315267_C_T 543 L>F No Jeffares_SNPs
I_3315706_T_C 689 M>T No Jeffares_SNPs

No associated diseases with Q9C100

3 regional properties for Q9C100

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 63 - 306 IPR003342
domain MIR motif 332 - 521 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 538 - 735 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Nucleus membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

1 GO annotations of biological process

Name Definition
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYEQLHAQS GQLRQRFPSK HSEIEDEVAN EKEELKDATK SALGEVKTNK KYYILGYFLV
70 80 90 100 110 120
PLLLTVIAGF VRVWKIADSN VVIWDEAHFG KFASYYLKHE FYFDVHPPLG KMLNAVAGKL
130 140 150 160 170 180
VGYDGSFDFS SGATYPEDLN YKFMRLWNAA FGTLCIPLVY FTALNFNYSF LAATLCTLMV
190 200 210 220 230 240
ALDNHLATIS RFILLDSMLL FFIISTFFCL SRYHVYHKAP FTFYWFKWLF LTGVCIGCVC
250 260 270 280 290 300
SVKLVGLFIT AVVGLYTVDE LWCLLNDKRV TWKAYAGHWI ARVCLLIFLP ILIYAFTFWI
310 320 330 340 350 360
QFAVLYRSGP GDAQMPSLFQ ARLEGSPLTK NPIDLMYGSK FTLKSRNPTG ALLHSHVQTY
370 380 390 400 410 420
PEGSEQQQVT GYHHKDGNNE WMFVPTHGVA YNYEENDPMN PILNGSVVRL IHPFTNRNLH
430 440 450 460 470 480
THKIPAPLNK RMYEVSGYGL GDVGDEKDYW IVNILYDTAH RDAYNVRSLS TVFQLYNPVV
490 500 510 520 530 540
GCYLSSSSSS LPSWGFGQIE MYCDPDPDPS NTDTQWNVEE HINPRLPEGS INDYPSSFWS
550 560 570 580 590 600
DFLHLNRAML RANNGLIPDE DKLDALRSEA YQWPFLLATL RMCGWGDNQI KYLLVGNPVA
610 620 630 640 650 660
YWFATSSLIV FALFVVGAVL AWRRRVLRWS QEACDTFHYA GIYPFLGWFF NYLPYYIMGR
670 680 690 700 710 720
VLYVHHYEPS YALSTFTAAF VVDWFTKKMP KIVRVVVFIS LYAIIAGVFI YFKDVTFGMH
730
GPASDFHRLR WLNSWNVHD