Q9C0Y5

PR
Gene name
pdr1 (SPAPB24D3.09c)
Protein name
ATP-binding cassette transporter pdr1
Names
ABC transporter pdr1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAPB24D3.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9C0Y5

Entry ID Method Resolution Chain Position Source
AF-Q9C0Y5-F1 Predicted AlphaFoldDB

29 variants for Q9C0Y5

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2967244_T_C 37 N>D No Jeffares_SNPs
I_2967235_G_A 40 H>Y No Jeffares_SNPs
I_2967111_C_T 81 R>Q No Jeffares_SNPs
I_2966789_G_T 188 H>Q No Jeffares_SNPs
I_2966742_G_A 204 A>V No Jeffares_SNPs
I_2966574_C_T 260 R>H No Jeffares_SNPs
I_2966193_G_A 387 A>V No Jeffares_SNPs
I_2966146_A_G 403 S>P No Jeffares_SNPs
I_2966125_A_G 410 Y>H No Jeffares_SNPs
I_2966116_G_A 413 Q>* No Jeffares_SNPs
I_2965992_C_T 454 R>K No Jeffares_SNPs
I_2965821_C_T 511 S>N No Jeffares_SNPs
I_2965666_T_C 563 I>V No Jeffares_SNPs
I_2965612_C_T 581 A>T No Jeffares_SNPs
I_2965288_T_A 689 I>F No Jeffares_SNPs
I_2965230_T_A 708 H>L No Jeffares_SNPs
I_2964793_G_C 854 L>V No Jeffares_SNPs
I_2964663_T_A 897 K>I No Jeffares_SNPs
I_2964655_T_C 900 S>G No Jeffares_SNPs
I_2964559_T_C 932 S>G No Jeffares_SNPs
I_2964343_C_T 1004 E>K No Jeffares_SNPs
I_2964265_C_T 1030 G>S No Jeffares_SNPs
I_2964190_T_A 1055 T>S No Jeffares_SNPs
I_2964165_G_C 1063 T>R No Jeffares_SNPs
I_2964155_C_T 1066 M>I No Jeffares_SNPs
I_2964076_C_T 1093 A>T No Jeffares_SNPs
I_2964070_C_T 1095 V>I No Jeffares_SNPs
I_2963880_G_A 1158 T>I No Jeffares_SNPs
I_2963746_G_A 1203 P>S No Jeffares_SNPs

No associated diseases with Q9C0Y5

3 regional properties for Q9C0Y5

Type Name Position InterPro Accession
domain Pyridoxamine 5'-phosphate oxidase, putative 33 - 116 IPR011576
domain Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal 171 - 211 IPR019576
conserved_site Pyridoxamine 5'-phosphate oxidase, conserved site 181 - 194 IPR019740

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEQEKGKGD LDDPNSKNTK CPDKFEQKVE EYLEVLNELH LTGRTSGFCM RNFTVEGAFN
70 80 90 100 110 120
PKFQIRSFFA QLLHPINIIF RTGPKRDIIP LVKGFDGYLQ PGSSLLVLGH EGSGGSTLLK
130 140 150 160 170 180
ALCGIVEENE RLNGSLHYDG LDYKIAHSQF KADLSYCGEG HSKVATITVR RLLEFVCSCR
190 200 210 220 230 240
LPASKYDHPR SHYIRRICEI IRDAFDLGDF YNHRILRVFN SGDQIKVDVA QTMCARPLIQ
250 260 270 280 290 300
CWDNNMRDFD SISVIDILSR IKVLSHKLGT TLVAIVSQAS DRIFHMFDMV TLMYEGEQIF
310 320 330 340 350 360
YGPTSRLKPY FLDLGFIPAK HSTTVEFVTS LTYPEMRIIN KKHQGFIPST PAEFRECWLR
370 380 390 400 410 420
SEDYAKLIKF MDRYEENHSD IHAFKDAKFD QTRLQKFLRW LNSNPCLIPY RLQVFATAKV
430 440 450 460 470 480
TFFQYLHDYS YIATFVFTYV FQALMLGSLF YNLRNESSEL YSRGSVLSNA IVFTAIQTMS
490 500 510 520 530 540
EVDIIFLKKS LFKEHRVQSL YHPSAALMGS SLVEFPMRIV VVTMYDIIVY FLSDLKRNAR
550 560 570 580 590 600
SFFIFYLFTI VITFCMSAVF RFIALLSTTA EIAALIGGIG ALVLIIFCGA VMPVQYIGWW
610 620 630 640 650 660
FRWIAYANPV NYGYESIMLN EFDGREIPCS LMAPAPDTAP IENNFCLATA GRTGTSIVSG
670 680 690 700 710 720
YQYLQVVYQY KADFLWRNCG IILGFAIFIL ASSLILANFI RYDRESVHIP EFQKRKSYSQ
730 740 750 760 770 780
VASSFLIEPQ DKPPSQTEPD NKKVDVSTTL STNDNLVLCW RDLNFTVVTK TSKKQILTNV
790 800 810 820 830 840
SGYLKKNTLT ALLGENKSGK SVLLRILSQR GIAGSVEGEI TLSGLKNPKN LRKRIGYVRK
850 860 870 880 890 900
NPLFISEYTV RETLRLHAAL RQSKQRSLSE QYAYVEYVID FLGLGEVADF IVGDMGKGLS
910 920 930 940 950 960
LYHKRLLSIA VELSARPGSI LLLDEPANGL DSQSAWMLVC ILQKLARSGL SILCSVSQPS
970 980 990 1000 1010 1020
SRILELFDMM LILDLNGNTV YYDTMGRDLS KLVNYFKRIH GTNEHSKDTA DFVLHCIQFL
1030 1040 1050 1060 1070 1080
KQGPEFDYAG AWASTNTHKQ IIEHVNFIMD NPELTDDDFP NETRFMTSFF FQIYKISMRN
1090 1100 1110 1120 1130 1140
FVAYWRDSSL LRARVAFNIV AGLIIGFSFY KQGVGVEETQ NKMFSAYMLT VASTSTMNGL
1150 1160 1170 1180 1190 1200
QPKFIYFRSI YEQYEQNTAI YSRTAFIIAF FLVEAVINCC FATLFFFGWY YPSGFYEFNH
1210 1220 1230 1240 1250 1260
NIPFYGGFAW LMLMIFTLYY TTLGIGIATI SPSIGTASII SGTAFVFIQY FNGMIQLPGV
1270 1280 1290 1300 1310 1320
IVGFWKWMDA LSPYKYFLEG MIGGVLHDAP ITCEKFEIHY VDPPPNYSCG EYFSSFLNSS
1330 1340 1350 1360 1370 1380
GHGIVYNPEA YSSCQYCPYK NADELMVGFG YHYNHKWRNF CIMIGYTAFN LGAAIALYYI
1390
IHKTPWKRLA ARFVPD