AiPD: Autoinhibited Protein Database

Q9BZM4

Gene name	ULBP3 (N2DL3, RAET1N)
Protein name	UL16-binding protein 3
Names	ALCAN-gamma, NKG2D ligand 3, N2DL-3, NKG2DL3, Retinoic acid early transcript 1N
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79465
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

175-244 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

175-244 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9BZM4

Entry ID	Method	Resolution	Chain	Position	Source
1KCG	X-ray	260 A	C	30-207	PDB
AF-Q9BZM4-F1	Predicted				AlphaFoldDB

234 variants for Q9BZM4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA366033370 rs1295674176	2	A>S		No	ClinGen gnomAD
CA4046710 rs200912438	3	A>E		No	ClinGen ExAC gnomAD
rs200912438 CA150037239	3	A>G		No	ClinGen ExAC gnomAD
CA4046709 rs564647046	4	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA366033336 rs1401918177	5	A>S		No	ClinGen gnomAD
rs1388975782 CA366033287	6	S>N		No	ClinGen gnomAD
rs905543384 CA150037197	6	S>R		No	ClinGen TOPMed gnomAD
CA4046707 rs761807316	8	A>E		No	ClinGen ExAC TOPMed gnomAD
CA4046708 rs371018793	8	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA366033194 rs1487636014	10	L>F		No	ClinGen TOPMed
CA4046706 rs377740812	11	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA366033165 rs377740812	11	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA366033131 rs1226697167	12	R>C		No	ClinGen Ensembl
rs934380315 CA150037173	12	R>H		No	ClinGen gnomAD
rs934380315 CA366033119	12	R>L		No	ClinGen gnomAD
TCGA novel	14	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366033037 rs1248945691	16	L>V		No	ClinGen TOPMed gnomAD
CA366032981 CA4046703 rs72501734	18	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA366032966 rs1369372638	19	L>P		No	ClinGen TOPMed
CA366032913 rs1339365158	21	F>L		No	ClinGen gnomAD
CA4046700 rs776177800	21	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1359987591 CA366032894	22	D>H		No	ClinGen TOPMed
rs1436732782 CA366032816	24	S>Y		No	ClinGen gnomAD
CA366032777 rs1438206181	25	G>A		No	ClinGen gnomAD
rs143819981 CA4046699	25	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201424815 CA150037168	26	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201424815 CA4046698	26	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1409122095 CA366032696	28	R>P		No	ClinGen gnomAD
CA366032698 rs1409122095	28	R>Q		No	ClinGen gnomAD
rs113233347 CA366032691	29	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs113233347 CA4046696	29	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA150037122 rs973221255	30	D>N		No	ClinGen TOPMed gnomAD
CA4046657 rs569651856	31	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs752756870 CA4046658	31	A>T	Variant assessed as Somatic; 4.749e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4046656 rs759614006	33	S>T		No	ClinGen ExAC gnomAD
TCGA novel	34	L>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366031033 rs1177090250	36	Y>C		No	ClinGen gnomAD
rs1476901702 CA366031005	40	I>V		No	ClinGen TOPMed
CA4046655 rs753688977	42	H>L		No	ClinGen ExAC gnomAD
TCGA novel	42	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366030977 rs1406029944	44	P>S		No	ClinGen gnomAD
TCGA novel	45	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4046653 rs549777601	45	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA366030964 rs1562520345	46	H>R		No	ClinGen Ensembl
CA4046652 rs772951130	46	H>Y		No	ClinGen ExAC gnomAD
rs771649601 CA4046651	47	G>E		No	ClinGen ExAC gnomAD
rs761330157 CA4046650	48	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs1256032909 CA366030951	48	Q>L		No	ClinGen TOPMed gnomAD
rs773904670 CA4046649	49	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1309465373 CA366030943	49	Q>H		No	ClinGen TOPMed
CA366030945 rs1269600381	49	Q>R		No	ClinGen gnomAD
CA4046648 rs769009568	50	W>*		No	ClinGen ExAC TOPMed gnomAD
CA820682341 rs1436173952	50	W>*		No	ClinGen TOPMed
CA4046647 rs769009568	50	W>C		No	ClinGen ExAC TOPMed gnomAD
rs747110297 CA366030930	51	C>F		No	ClinGen TOPMed gnomAD
CA150034908 rs747110297	51	C>Y		No	ClinGen TOPMed gnomAD
CA4046646 rs781525558	52	E>K		No	ClinGen ExAC gnomAD
CA366030908 rs1370400129	54	Q>H		No	ClinGen TOPMed
CA4046645 rs529831883	56	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
CA150034888 rs149415565	57	V>M		No	ClinGen ESP TOPMed gnomAD
CA4046644 rs747294120	58	D>N		No	ClinGen ExAC gnomAD
rs778145278 CA4046643	59	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA4046642 rs199897950	59	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs199897950 CA150034885	59	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA4046640 rs779173572	60	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1451206571 CA366030818	62	F>V		No	ClinGen TOPMed
CA4046638 rs138871352	65	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1185471977 CA366030770	66	D>N		No	ClinGen gnomAD
CA366030739 rs1484606727	68	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA366030729 rs1249575740	69	S>N		No	ClinGen gnomAD
CA366030685 rs1347910144	71	K>N		No	ClinGen Ensembl
CA366030674 rs1247004599	72	V>L		No	ClinGen TOPMed
CA4046636 rs760525576	74	S>P		No	ClinGen ExAC gnomAD
rs150119539 CA4046635	74	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA366030602 rs1294765745	75	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs761516474 CA4046633	75	M>V		No	ClinGen ExAC TOPMed gnomAD
CA4046632 rs369161228	76	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	77	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366030546 rs1322809393	78	L>P		No	ClinGen gnomAD
CA366030549 rs1363049487	78	L>V		No	ClinGen gnomAD
rs565612520 CA150034785	82	L>R		No	ClinGen 1000Genomes gnomAD
rs1459741432 CA366030434 COSM1441161	84	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs777224791 CA4046629	86	D>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	86	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759322111 CA4046627	87	A>G		No	ClinGen ExAC TOPMed gnomAD
rs771275850 CA4046628	87	A>T		No	ClinGen ExAC gnomAD
rs759322111 CA4046626	87	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1391410577 CA366030349	89	G>*		No	ClinGen gnomAD
rs137927077 CA4046625	89	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1391410577 CA366030346	89	G>R		No	ClinGen gnomAD
rs748432911 CA4046624	93	E>D		No	ClinGen ExAC gnomAD
CA4046623 rs779230451	94	M>T		No	ClinGen ExAC gnomAD
rs373626721 CA150034760	97	E>K		No	ClinGen Ensembl
CA4046622 rs755120854	97	E>V		No	ClinGen ExAC TOPMed gnomAD
CA4046620 rs749262581	98	V>M		No	ClinGen ExAC gnomAD
rs1340171392 CA366030118	99	G>V		No	ClinGen TOPMed gnomAD
rs756067198 CA4046618	103	R>I		No	ClinGen ExAC gnomAD
CA366029999 rs1247315196	104	L>P		No	ClinGen TOPMed
TCGA novel	107	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366029903 rs1465251700	108	D>N		No	ClinGen TOPMed
rs1189972009 CA366029866	109	T>I		No	ClinGen TOPMed
CA366029875 rs1312885353	109	T>S		No	ClinGen gnomAD
CA4046616 rs34672740	110	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046615 rs757021798	110	E>D		No	ClinGen ExAC TOPMed
CA4046614 rs140233188	111	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046613 rs763695201	111	L>P		No	ClinGen ExAC TOPMed gnomAD
CA4046612 rs201893141	112	E>V		No	ClinGen ExAC TOPMed gnomAD
CA4046610 rs375239450	115	T>I		No	ClinGen ESP ExAC gnomAD
rs1372923068 CA366029736	116	P>S		No	ClinGen gnomAD
CA4046609 rs371894085	117	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA366029695 rs1453260135	117	S>N		No	ClinGen TOPMed gnomAD
rs1453260135 CA366029692	117	S>T		No	ClinGen TOPMed gnomAD
rs1260356177 CA366029607	118	G>E		No	ClinGen gnomAD
CA4046608 rs773833519	118	G>R		No	ClinGen ExAC gnomAD
rs769063868 CA4046583	119	P>A		No	ClinGen ExAC gnomAD
CA366029598 rs763120446	119	P>H		No	ClinGen ExAC TOPMed gnomAD
CA366029596 rs763120446	119	P>L		No	ClinGen ExAC TOPMed gnomAD
CA4046582 rs763120446	119	P>R		No	ClinGen ExAC TOPMed gnomAD
rs769063868 CA366029600	119	P>S		No	ClinGen ExAC gnomAD
CA4046581 rs148156422	121	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745905985 CA4046579	123	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA150034444 rs929102324	123	Q>R		No	ClinGen TOPMed
CA366029541 rs1335679485	124	V>F		No	ClinGen gnomAD
CA366029523 rs1396078365	125	R>S		No	ClinGen gnomAD
rs781110610 CA4046578	126	M>L		No	ClinGen ExAC TOPMed gnomAD
rs200023001 CA4046577	127	S>P		No	ClinGen ExAC TOPMed gnomAD
rs200023001 CA366029495	127	S>T		No	ClinGen ExAC TOPMed gnomAD
rs746935840 CA4046576	128	C>R		No	ClinGen ExAC gnomAD
rs777495265 CA4046575	128	C>S		No	ClinGen ExAC gnomAD
CA4046574 rs758190832	129	E>*		No	ClinGen ExAC gnomAD
CA4046573 rs752315575	129	E>A		No	ClinGen ExAC
rs778590282 CA366029455	129	E>D		No	ClinGen ExAC gnomAD
rs375719409 CA150034428	132	A>G		No	ClinGen ESP TOPMed
CA4046569 rs762480458	133	D>H		No	ClinGen ExAC TOPMed gnomAD
CA4046568 rs762480458	133	D>N		No	ClinGen ExAC TOPMed gnomAD
CA366029376 rs1305069981	134	G>V		No	ClinGen TOPMed
rs371828950 CA4046565	137	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4046564 rs34547018	137	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367595267 CA150034406	141	Q>R		No	ClinGen ESP
CA4046563 rs200807610	143	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200807610 CA366029256	143	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA150034400 rs1009574127	144	F>L		No	ClinGen TOPMed
COSM303518 rs144986963 CA4046561	145	D>N	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA150034370 rs747663456	146	G>*		No	ClinGen Ensembl
CA4046559 rs35374376	147	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046558 rs35374376	147	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046560 rs372155960	147	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA150034355 rs977639148	149	F>I		No	ClinGen TOPMed
CA4046557 rs771796839	150	L>H		No	ClinGen ExAC TOPMed gnomAD
CA4046556 rs747912077	153	D>V		No	ClinGen ExAC gnomAD
CA366029044 rs1390135242	154	S>A		No	ClinGen TOPMed gnomAD
CA366029026 rs1415942142	155	N>D		No	ClinGen TOPMed gnomAD
rs1460932782 CA366028935	158	K>R		No	ClinGen gnomAD
rs778446638 CA4046554	159	W>*		No	ClinGen ExAC gnomAD
rs1389588784 CA366028900	160	T>R		No	ClinGen gnomAD
CA366028886 rs1389735115	161	V>E		No	ClinGen TOPMed
CA366028855 rs1582865512	163	H>L		No	ClinGen Ensembl
rs367950741 CA4046553	163	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA4046549 rs752025572	164	A>G		No	ClinGen ExAC gnomAD
rs571728197 CA4046551	164	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs571728197 CA4046550	164	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA150034317 rs752025572	164	A>V		No	ClinGen ExAC gnomAD
rs373258012 CA366028781	168	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373258012 CA4046544	168	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4046546 rs35696295	168	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046543 rs776802014	169	M>I		No	ClinGen ExAC gnomAD
rs531898596 CA4046542	171	E>*		No	ClinGen 1000Genomes ExAC gnomAD
rs531898596 CA4046541	171	E>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	171	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366028715 CA4046539 rs771989736	172	K>N		No	ClinGen ExAC gnomAD
CA4046540 rs773028300	172	K>T		No	ClinGen ExAC gnomAD
rs1409249334 CA366028663	176	D>E		No	ClinGen gnomAD
rs376892807 CA4046537	176	D>G		No	ClinGen ESP ExAC gnomAD
CA366028641 rs1451406151	178	G>E		No	ClinGen gnomAD
CA4046535 rs371776868	178	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1190771817 CA366028623	180	T>P		No	ClinGen TOPMed gnomAD
rs892424181 CA150034234	181	T>A		No	ClinGen Ensembl
CA366028605 rs1249916868	181	T>S		No	ClinGen TOPMed
rs1477247718 CA366028594	182	F>Y		No	ClinGen gnomAD
CA366028546 rs1248781694	185	M>I		No	ClinGen gnomAD
CA150034233 rs755794444	185	M>T		No	ClinGen TOPMed
COSM1698130 rs779800228 CA4046533	186	V>I	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs906768155 CA150034222	187	S>L		No	ClinGen TOPMed gnomAD
CA366028515 rs1206748096	188	M>I		No	ClinGen gnomAD
rs367947532 CA4046531	188	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1458203422 CA366028525	188	M>V		No	ClinGen TOPMed
rs1046585526 CA150034217	190	D>H		No	ClinGen TOPMed
TCGA novel	191	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3662200 CA4046530 rs778154204	191	C>Y	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA366028443 rs1275273401	193	S>N		No	ClinGen gnomAD
CA150034180 rs202219794	193	S>R		No	ClinGen 1000Genomes
rs753139438 CA4046528	193	S>R		No	ClinGen ExAC gnomAD
rs765630678 CA4046527	194	W>*		No	ClinGen ExAC gnomAD
rs200021594 CA150034175	194	W>G		No	ClinGen 1000Genomes
CA4046526 rs755287168	195	L>H		No	ClinGen ExAC TOPMed gnomAD
CA366028421 rs1348631817	195	L>I		No	ClinGen gnomAD
CA150034173 rs755287168	195	L>P		No	ClinGen ExAC TOPMed gnomAD
CA150034129 rs936495698	197	D>E		No	ClinGen Ensembl
CA4046522 COSM3366319 rs773401265	197	D>G	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs760685893 CA366028393	197	D>N		No	ClinGen ExAC TOPMed gnomAD
rs760685893 CA4046523	197	D>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	200	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366028350 rs1311528843	200	M>T		No	ClinGen TOPMed
CA366028335 rs1472459372	201	H>Q		No	ClinGen TOPMed gnomAD
rs1192181336 CA366028338	201	H>R		No	ClinGen TOPMed gnomAD
CA366028294 rs761853967	206	L>V		No	ClinGen ExAC gnomAD
CA366028284 rs897613442	207	E>K		No	ClinGen TOPMed
CA150034120 rs897613442	207	E>Q		No	ClinGen TOPMed
CA366028260 rs1329092709	209	T>A		No	ClinGen TOPMed
rs1175548325 CA366028168	210	A>E		No	ClinGen TOPMed
rs1302504070 CA366028127	212	P>H		No	ClinGen gnomAD
CA366028130 rs1179674087	212	P>S		No	ClinGen gnomAD
rs139865016 CA4046503	214	M>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046502 rs139865016	214	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4046504 rs756428625	214	M>V		No	ClinGen ExAC TOPMed gnomAD
rs751573932 CA4046500	218	L>V		No	ClinGen ExAC gnomAD
rs764053703 CA4046499	222	K>R		No	ClinGen ExAC gnomAD
CA4046498 rs762851206	223	A>T		No	ClinGen ExAC gnomAD
rs1310483909 CA366027956	224	I>M		No	ClinGen TOPMed gnomAD
rs150907952 CA4046497	224	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs769470778 CA4046496	227	T>I		No	ClinGen ExAC gnomAD
rs1582864934 CA366027919	227	T>P		No	ClinGen Ensembl
rs1381339101 CA366027902	228	L>F		No	ClinGen gnomAD
CA366027898 rs1441043481	228	L>P		No	ClinGen TOPMed
rs1582864924 CA366027880	229	S>I		No	ClinGen Ensembl
rs1562519702 CA366027887	229	S>R		No	ClinGen Ensembl
rs1337670488 CA366027865	230	P>S		No	ClinGen gnomAD
CA366027768 rs1386697117	234	L>V		No	ClinGen gnomAD
COSM1545096 rs1323012079 CA366027747	235	I>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs759272747 CA4046495	236	I>N		No	ClinGen ExAC gnomAD
CA4046494 rs776124788	237	L>H		No	ClinGen ExAC gnomAD
CA4046493 rs756364055	240	I>T		No	ClinGen ExAC gnomAD
rs1436050936 CA366027515	244	I>T		No	ClinGen gnomAD
rs1425046132 CA366027493	245	I>C		No	ClinGen gnomAD

No associated diseases with Q9BZM4

1 regional properties for Q9BZM4

Type	Name	Position	InterPro Accession
domain	MHC class I-like antigen recognition-like	31 - 206	IPR011161

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor, GPI-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
anchored component of plasma membrane	The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
natural killer cell lectin-like receptor binding	Binding to a lectin-like natural killer cell receptor.

2 GO annotations of biological process

Name	Definition
natural killer cell activation	The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.
natural killer cell mediated cytotoxicity	The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P15813	CD1D	Antigen-presenting glycoprotein CD1d	Homo sapiens (Human)	PR
P29017	CD1C	T-cell surface glycoprotein CD1c	Homo sapiens (Human)	PR
P55899	FCGRT	IgG receptor FcRn large subunit p51	Homo sapiens (Human)	PR

10	20	30	40	50	60
MAAAASPAIL	PRLAILPYLL	FDWSGTGRAD	AHSLWYNFTI	IHLPRHGQQW	CEVQSQVDQK
70	80	90	100	110	120
NFLSYDCGSD	KVLSMGHLEE	QLYATDAWGK	QLEMLREVGQ	RLRLELADTE	LEDFTPSGPL
130	140	150	160	170	180
TLQVRMSCEC	EADGYIRGSW	QFSFDGRKFL	LFDSNNRKWT	VVHAGARRMK	EKWEKDSGLT
190	200	210	220	230	240
TFFKMVSMRD	CKSWLRDFLM	HRKKRLEPTA	PPTMAPGLAQ	PKAIATTLSP	WSFLIILCFI

LPGI