AiPD: Autoinhibited Protein Database

Q9BY66

Gene name	KDM5D (HY, HYA, JARID1D, KIAA0234, SMCY)
Protein name	Lysine-specific demethylase 5D
Names	Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8284
EC number	1.14.11.67: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

201-276 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

201-276 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9BY66

Entry ID	Method	Resolution	Chain	Position	Source
2E6R	NMR	-	A	306-384	PDB
2YQE	NMR	-	A	79-171	PDB
AF-Q9BY66-F1	Predicted				AlphaFoldDB

344 variants for Q9BY66

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs199813705 CA10575102	3	P>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs199813705 CA10575101	3	P>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA337441312 rs946898687	4	G>A		No	ClinGen gnomAD
CA414847551 rs946898687	4	G>E		No	ClinGen gnomAD
CA10575100 rs760637210	4	G>R		No	ClinGen ExAC gnomAD
rs1569369743 CA414847382	15	P>L		No	ClinGen Ensembl
CA10575096 rs774041797	17	F>I		No	ClinGen ExAC gnomAD
CA10575095 rs768207947	25	Q>R		No	ClinGen ExAC gnomAD
CA414847157 rs1405878724	31	I>V		No	ClinGen gnomAD
rs1367436464 CA414847092	35	R>M		No	ClinGen gnomAD
CA10575094 rs749599093	39	E>G		No	ClinGen ExAC gnomAD
rs780597809 CA414847022	40	K>M		No	ClinGen ExAC gnomAD
rs780597809 CA10575093	40	K>T		No	ClinGen ExAC gnomAD
CA10575092 rs756644777	47	R>C		No	ClinGen ExAC gnomAD
TCGA novel	47	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1365840574 CA414846722	58	V>A		No	ClinGen gnomAD
rs1274321260 CA414846718	59	E>Q		No	ClinGen gnomAD
CA10575085 rs753589349	62	N>S		No	ClinGen ExAC gnomAD
rs2521574 CA337441284	64	R>K		No	ClinGen Ensembl
CA337441283 rs371502336	68	R>C		No	ClinGen ESP gnomAD
rs1034100630 CA337441282	69	V>I		No	ClinGen gnomAD
CA337441256 rs267606535	88	Q>*		No	ClinGen Ensembl
TCGA novel	91	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1325695403 CA414846058	92	F>L		No	ClinGen gnomAD
CA414845919 rs1569368909	102	I>T		No	ClinGen Ensembl
CA10575071 rs781713460	104	N>S		No	ClinGen ExAC gnomAD
rs777742522 CA10575068	115	L>F		No	ClinGen ExAC gnomAD
rs762596355 CA10575058	118	I>F		No	ClinGen ExAC
CA414845574 rs1603546075	124	G>A		No	ClinGen Ensembl
CA414845515 rs1603546074	128	I>M		No	ClinGen Ensembl
rs1378103890 CA414845471	131	D>G		No	ClinGen gnomAD
CA10575057 rs769631336	132	R>H		No	ClinGen ExAC gnomAD
rs769631336 CA10575056	132	R>L		No	ClinGen ExAC gnomAD
CA414845447 rs1454244319	133	R>Q		No	ClinGen gnomAD
rs776861979 CA10575054	143	Y>H		No	ClinGen ExAC gnomAD
CA414845295 rs1345753651	144	P>L		No	ClinGen Ensembl
rs771425528 CA10575053	149	I>T		No	ClinGen ExAC gnomAD
CA10575052 rs747492393	151	S>C		No	ClinGen ExAC gnomAD
rs1422595247 CA414845096	159	R>C		No	ClinGen gnomAD
CA414845090 rs1413436679	159	R>L		No	ClinGen gnomAD
CA10575049 rs748291282	160	I>V		No	ClinGen ExAC gnomAD
CA10575047 rs755199132	173	H>R		No	ClinGen ExAC gnomAD
rs750193514 CA10575046	174	V>M		No	ClinGen ExAC gnomAD
CA414844817 rs1291291671	176	C>G		No	ClinGen gnomAD
CA414844756 rs1456833884	180	P>Q		No	ClinGen gnomAD
rs764912539 CA10575038	183	N>H		No	ClinGen ExAC gnomAD
rs1164578875 CA414844712	183	N>S		No	ClinGen gnomAD
CA414844544 rs1419904980	195	I>M		No	ClinGen gnomAD
TCGA novel	198	R>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337441214 rs867740189	203	P>H		No	ClinGen Ensembl
rs771177727 CA10575035	208	S>N		No	ClinGen ExAC gnomAD
CA10575034 rs369689683	211	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs868219886 CA337441213	212	R>L		No	ClinGen Ensembl
rs1224670916 CA414844278	212	R>W		No	ClinGen gnomAD
rs1358953604 CA414844017	220	P>R		No	ClinGen gnomAD
CA414843972 rs1454492868	223	T>A		No	ClinGen gnomAD
CA414843974 rs1454492868	223	T>P		No	ClinGen gnomAD
rs1365816310 CA414843832	230	H>P		No	ClinGen gnomAD
rs1432628088 CA414843727	235	K>N		No	ClinGen gnomAD
rs367811199 CA10575024	238	I>M		No	ClinGen ESP ExAC gnomAD
rs766143895 CA10575023	239	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
CA414843637 rs1487269358	242	G>R		No	ClinGen gnomAD
rs777798643 CA10575022	249	G>V		No	ClinGen ExAC gnomAD
CA337441134 rs374506583	253	K>E		No	ClinGen ESP
rs1352363980 CA414843421	254	D>G		No	ClinGen gnomAD
TCGA novel	254	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337441132 rs973739517	256	D>E		No	ClinGen Ensembl
CA10575020 rs752211172	256	D>V		No	ClinGen ExAC gnomAD
CA10575019 rs764857307	259	V>L		No	ClinGen ExAC gnomAD
CA10575009 rs750429701	265	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1461547786	268	T>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA10575005 rs746730690	270	T>M		No	ClinGen ExAC
CA10575006 rs3212285	270	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1228823823 CA414843000	274	E>V		No	ClinGen gnomAD
rs758357463 CA10575003	278	G>C		No	ClinGen ExAC gnomAD
CA10575002 rs748073274	278	G>D		No	ClinGen ExAC gnomAD
rs372522294 CA10575001	284	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA10574999 rs753444324	289	H>L		No	ClinGen ExAC gnomAD
rs754442283 CA10575000	289	H>Y		No	ClinGen ExAC gnomAD
rs755822885 CA10574998	296	T>I		No	ClinGen ExAC gnomAD
rs755822885 CA10574997	296	T>S		No	ClinGen ExAC gnomAD
rs1603546016 CA414842590	299	T>N		No	ClinGen Ensembl
rs1245759378 CA414842211	315	Y>C		No	ClinGen gnomAD
CA10574983 rs775246871	315	Y>D		No	ClinGen 1000Genomes ExAC
rs777038395 CA10574982	321	S>F		No	ClinGen ExAC gnomAD
CA10574981 rs771957697	341	I>V		No	ClinGen ExAC gnomAD
rs778700335 CA10574979	347	P>L		No	ClinGen ExAC gnomAD
CA10574978 rs768650836	364	A>V		No	ClinGen ExAC
rs764445193 CA10574970	367	K>E		No	ClinGen ExAC gnomAD
CA337440978 rs899613472	377	Q>E		No	ClinGen gnomAD
CA10574969 rs763543567	381	E>D		No	ClinGen ExAC
CA10574966 rs759727009	393	S>F		No	ClinGen ExAC gnomAD
rs776987482 CA10574964	396	S>F		No	ClinGen ExAC gnomAD
rs771336208 CA10574963	397	D>N		No	ClinGen ExAC gnomAD
rs761640649 CA10574962	400	N>S		No	ClinGen ExAC gnomAD
rs1490676505 CA414840490	411	V>A		No	ClinGen gnomAD
rs61750268 CA337440959	411	V>L		No	ClinGen Ensembl
rs1046692785 CA337440957	413	K>N		No	ClinGen Ensembl
CA414840376 rs1569366470	418	L>Q		No	ClinGen Ensembl
rs1603545972 CA414840241	425	D>E		No	ClinGen Ensembl
CA337440950 rs2032618 CA337440952	426	V>L		No	ClinGen ExAC gnomAD
rs2032618 CA10574951	426	V>M		No	ClinGen ExAC gnomAD
CA337440948 rs929564908	429	E>D		No	ClinGen Ensembl
rs753213379 CA10574950	434	I>T		No	ClinGen ExAC gnomAD
rs928869795 CA337440946	446	S>N		No	ClinGen Ensembl
rs982052810 CA337440944	447	N>S		No	ClinGen Ensembl
rs1262574616 CA414852185	460	A>V		No	ClinGen gnomAD
rs775488459 CA10574939	462	S>N		No	ClinGen ExAC gnomAD
CA10574938 rs769740357	464	W>R		No	ClinGen ExAC gnomAD
CA10574937 rs745319454	469	M>I		No	ClinGen ExAC gnomAD
rs1213936295 CA414852079	470	P>A		No	ClinGen gnomAD
CA10574935 rs770519026	481	N>S		No	ClinGen ExAC gnomAD
rs746649132 CA10574934	482	A>T		No	ClinGen ExAC gnomAD
CA10574933 rs777326175	490	P>S		No	ClinGen ExAC gnomAD
CA414851693 rs1168882283	504	H>R		No	ClinGen gnomAD
rs866860857 CA337440495	506	E>D		No	ClinGen Ensembl
rs1188716288 CA414851582	513	I>T		No	ClinGen gnomAD
CA10574932 rs758782377	513	I>V		No	ClinGen ExAC gnomAD
rs748518487 CA10574931	515	Y>C		No	ClinGen ExAC gnomAD
CA10574922 rs775155250	519	G>A		No	ClinGen ExAC gnomAD
rs759494962 CA10574920	529	S>P		No	ClinGen ExAC
TCGA novel	534	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337440481 rs1042221646	537	E>D		No	ClinGen gnomAD
CA10574919 rs776595397	541	M>I		No	ClinGen ExAC gnomAD
rs770392415 CA10574918	548	D>E		No	ClinGen ExAC gnomAD
CA414851020 rs1248500921	561	M>V		No	ClinGen gnomAD
CA10574915 rs771635442	569	H>R		No	ClinGen ExAC gnomAD
rs756207753 CA10574908	589	R>H		No	ClinGen ExAC gnomAD
CA10574907 rs775977354	597	Q>FC*		No	ClinGen ExAC gnomAD
CA414850307 rs1197109051	617	R>S		No	ClinGen gnomAD
CA10574899 rs753768084	618	Q>R		No	ClinGen ExAC gnomAD
rs1269319594 CA414850271	620	I>V		No	ClinGen gnomAD
rs766359320 CA10574898	625	R>L		No	ClinGen ExAC gnomAD
rs766359320 CA337440299	625	R>Q		No	ClinGen ExAC gnomAD
CA10574897 rs760173648	627	R>Q		No	ClinGen ExAC gnomAD
CA10574896 rs772599560	629	Y>S		No	ClinGen ExAC gnomAD
CA414850124 rs1318134868	633	S>F		No	ClinGen gnomAD
rs1603545791 CA414850090	636	E>*		No	ClinGen Ensembl
CA414850031 rs1222215197	641	M>V		No	ClinGen gnomAD
TCGA novel	646	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774188432 CA10574892	647	T>M		No	ClinGen ExAC gnomAD
rs1383291648 CA414849916	651	N>D		No	ClinGen gnomAD
CA10574890 rs749730855	651	N>S		No	ClinGen ExAC gnomAD
rs780651186 CA10574889	653	A>P		No	ClinGen ExAC gnomAD
CA10574888 rs770210674	656	V>A		No	ClinGen ExAC gnomAD
rs1390920626 CA414849870	656	V>L		No	ClinGen gnomAD
rs745923572 CA10574887	657	H>R		No	ClinGen ExAC gnomAD
rs781158387 CA10574886	661	F>L		No	ClinGen ExAC gnomAD
rs1201540443 CA414849785	662	I>V		No	ClinGen gnomAD
rs1426466778 CA414849698	668	R>Q		No	ClinGen gnomAD
CA10574885 rs757411182	669	R>C		No	ClinGen ExAC gnomAD
CA10574877 rs377092542	679	V>I		No	ClinGen ESP ExAC gnomAD
rs1469317416 CA414849531	681	E>Q		No	ClinGen gnomAD
rs774135485 CA10574876	683	E>D		No	ClinGen ExAC gnomAD
CA414849492 rs1460408001	684	R>Q		No	ClinGen gnomAD
rs768437804 CA10574874	690	L>F		No	ClinGen ExAC gnomAD
CA10574873 rs763346143	705	F>L		No	ClinGen ExAC gnomAD
rs1182622590 CA414849201	710	A>T		No	ClinGen gnomAD
rs776031237 CA10574872	713	D>N		No	ClinGen ExAC gnomAD
rs1264465071 CA414849124	716	D>G		No	ClinGen gnomAD
rs938158701 CA337440268 COSM3391915	725	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated Ensembl
rs746341780 CA10574870	732	S>G		No	ClinGen ExAC gnomAD
rs781740926 CA10574869	732	S>R		No	ClinGen ExAC gnomAD
CA414848869 rs1569363348	738	R>Q		No	ClinGen Ensembl
rs1395746660 CA414848825	740	R>Q		No	ClinGen gnomAD
rs1383172771 CA414848651	756	R>Q		No	ClinGen gnomAD
rs544669203 CA10574863	762	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs544669203 CA10574862	762	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA414848555 rs1238692765	765	N>D		No	ClinGen gnomAD
rs755984781 CA10574861	768	R>Q		No	ClinGen ExAC
CA414848401 rs1250382118	777	R>H		No	ClinGen gnomAD
rs1603545779 CA414848267	787	L>M		No	ClinGen Ensembl
CA10574849 rs771480596	792	R>H		No	ClinGen ExAC gnomAD
CA10574848 rs747021428	795	R>S		No	ClinGen ExAC gnomAD
rs772231807 CA10574845	802	L>H		No	ClinGen ExAC gnomAD
CA10574844 rs748348134	804	R>*		No	ClinGen ExAC gnomAD
rs778452697 CA10574842	812	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA414847928 rs1222276999	818	Q>*		No	ClinGen gnomAD
CA10574840 rs780925672	828	A>G		No	ClinGen ExAC gnomAD
CA10574835 rs752283213	835	L>Q		No	ClinGen ExAC gnomAD
rs764993727 CA10574834	841	R>Q		No	ClinGen ExAC gnomAD
rs1315713234 CA414847717	848	G>S		No	ClinGen gnomAD
CA10574833 rs759759371	848	G>V		No	ClinGen ExAC gnomAD
rs1603545733 CA414847674	854	M>I		No	ClinGen Ensembl
rs766830155 CA10574831	854	M>L		No	ClinGen ExAC gnomAD
rs761191128 CA10574830	856	Q>H		No	ClinGen ExAC gnomAD
CA414847654 rs1427862909	857	I>T		No	ClinGen gnomAD
rs1478528734 CA414847625	861	K>N		No	ClinGen gnomAD
rs1199364235 CA414847627	861	K>R		No	ClinGen gnomAD
rs1190780635 CA414847544	868	E>Q		No	ClinGen gnomAD
rs770902573 CA10574822	869	A>T		No	ClinGen ExAC gnomAD
rs1242611146 CA414847460	875	R>C		No	ClinGen gnomAD
rs777929353 CA10574820	878	L>M		No	ClinGen ExAC gnomAD
rs777929353 CA10574821	878	L>V		No	ClinGen ExAC gnomAD
CA337440017 rs1031595391	879	A>V		No	ClinGen Ensembl
CA414847348 rs1313936262	884	S>R		No	ClinGen gnomAD
rs1213816138 CA414847291	889	R>Q		No	ClinGen gnomAD
rs757964688 CA10574819	889	R>W		No	ClinGen ExAC gnomAD
CA10574818 rs752261194	890	S>F		No	ClinGen ExAC gnomAD
rs1299294064 CA414847228	894	R>S		No	ClinGen gnomAD
CA10574816 rs754688597	902	V>A		No	ClinGen ExAC gnomAD
rs1414726919 CA414847016	910	Q>H		No	ClinGen Ensembl
CA10574815 rs373422020	910	Q>L		No	ClinGen ESP ExAC gnomAD
CA10574814 rs766705675	911	Q>K		No	ClinGen ExAC gnomAD
CA414846933 rs1361452542	916	Q>R		No	ClinGen gnomAD
rs1409704100 CA414846832	925	L>P		No	ClinGen gnomAD
CA10574811 rs768026210	926	A>S		No	ClinGen ExAC gnomAD
rs866052642 CA337440005	926	A>V		No	ClinGen Ensembl
CA10574810 rs761733755	932	G>D		No	ClinGen ExAC gnomAD
rs1443079914 CA414846704	937	M>L		No	ClinGen gnomAD
rs774523231 CA10574809	948	A>P		No	ClinGen ExAC gnomAD
rs774523231 CA414846571	948	A>T		No	ClinGen ExAC gnomAD
CA337440001 rs765530292	950	S>G		No	ClinGen 1000Genomes
CA10574808 rs768714690	957	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	962	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1683052 CA10574804 rs746855060	969	R>C	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA414846368 rs1276596263	969	R>H		No	ClinGen gnomAD
CA10574803 rs777792467	972	E>K		No	ClinGen ExAC gnomAD
rs1358347504 CA414846307	975	H>R		No	ClinGen gnomAD
CA10574797 rs779748723	984	H>L		No	ClinGen ExAC
CA10574796 rs779748723	984	H>P		No	ClinGen ExAC
rs767973344 CA10574793	986	P>A		No	ClinGen ExAC gnomAD
CA10574792 rs762407272	994	R>H		No	ClinGen ExAC gnomAD
rs752058053 CA10574791	1025	E>A		No	ClinGen ExAC gnomAD
CA10574782 rs748094399	1032	Y>H		No	ClinGen ExAC gnomAD
CA10574781 rs774193762	1036	D>G		No	ClinGen ExAC gnomAD
CA337439914 rs868449081	1039	E>G		No	ClinGen Ensembl
rs768207252 CA10574780	1046	R>Q		No	ClinGen ExAC gnomAD
rs1484720528 CA414845225	1057	Q>E		No	ClinGen gnomAD
rs1259604290 CA414845136	1064	T>A		No	ClinGen gnomAD
CA10574779 rs748855039	1072	A>T		No	ClinGen ExAC gnomAD
rs779615383 CA10574778	1078	K>R		No	ClinGen ExAC gnomAD
CA414844861 rs1270524064	1084	T>A		No	ClinGen gnomAD
CA10574777 rs755795687	1086	L>V		No	ClinGen ExAC gnomAD
CA414844755 rs1603545710	1091	P>Q		No	ClinGen Ensembl
CA414844705 rs1260554707	1095	A>T		No	ClinGen gnomAD
rs35247789 CA10574767	1099	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA10574765 rs761578749	1100	T>P		No	ClinGen ExAC gnomAD
rs774331690 CA10574764	1102	R>H		No	ClinGen ExAC gnomAD
CA337439886 rs202137598	1104	R>Q		No	ClinGen Ensembl
COSM1737443 rs768481960 CA10574763	1109	A>V	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs775005055 CA10574761	1114	Q>H		No	ClinGen ExAC gnomAD
rs769345125 CA10574760	1115	C>Y		No	ClinGen ExAC gnomAD
CA337439881 rs963453320	1121	G>R		No	ClinGen gnomAD
CA10574758 rs764239225	1129	D>N		No	ClinGen ExAC gnomAD
rs1258924572 CA414844261	1131	G>S		No	ClinGen Ensembl
rs1202723144 CA414844197	1134	I>T		No	ClinGen gnomAD
rs754107673 CA10574750	1137	F>L		No	ClinGen ExAC gnomAD
CA414844153 rs1229398035	1138	K>N		No	ClinGen gnomAD
CA414844088 rs1312968356	1146	E>A		No	ClinGen gnomAD
CA10574749 rs766567095	1147	G>D		No	ClinGen ExAC
CA414844077 rs1244103713	1148	I>V		No	ClinGen gnomAD
CA10574748 rs761610918	1152	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1336027684 CA414844046	1153	R>C		No	ClinGen gnomAD
rs1448317143 CA414844042	1153	R>L		No	ClinGen gnomAD
rs1369711588 CA414844003	1157	A>G		No	ClinGen gnomAD
rs1431221988 CA414843984	1159	P>S		No	ClinGen gnomAD
rs1363287921 CA414843954	1161	P>L		No	ClinGen gnomAD
CA414843953 rs1603545701	1162	L>M		No	ClinGen Ensembl
rs764045028 CA10574746	1162	L>Q		No	ClinGen ExAC gnomAD
CA414843881 rs1472808224	1169	S>P		No	ClinGen gnomAD
rs1603545697 CA414843836	1173	S>C		No	ClinGen Ensembl
CA414843823 rs1190219102	1174	I>M		No	ClinGen gnomAD
rs1471932443 CA414843762	1180	V>L		No	ClinGen gnomAD
rs1251521594 CA414843736	1183	G>R		No	ClinGen gnomAD
CA337439876 rs1050807 VAR_032991	1186	V>L		No	ClinGen UniProt Ensembl dbSNP
rs1035593148 CA337439874	1193	Q>L		No	ClinGen Ensembl
rs565630460 CA10574742	1217	S>P		No	ClinGen ExAC gnomAD
rs1357058616 CA414843248	1226	D>N		No	ClinGen gnomAD
CA10574739 rs770490752	1236	R>H		No	ClinGen ExAC gnomAD
CA10574738 rs373978184	1238	R>Q		No	ClinGen ESP ExAC gnomAD
rs778017625 CA10574737	1245	I>V		No	ClinGen ExAC gnomAD
CA337439864 rs866336746	1256	P>S		No	ClinGen Ensembl
CA10574734 rs779628367	1257	V>L		No	ClinGen ExAC gnomAD
CA414842950 rs779628367	1257	V>M		No	ClinGen ExAC gnomAD
CA414842941 rs1456079779	1258	R>Q		No	ClinGen gnomAD
CA414842942 rs1276230357	1258	R>W		No	ClinGen Ensembl
CA414842751 rs1411817412	1275	W>*		No	ClinGen gnomAD
CA10574733 rs755094195	1278	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA414842708 rs1473741747	1278	R>H		No	ClinGen gnomAD
CA337439860 rs747615980	1282	A>T		No	ClinGen 1000Genomes
CA414842664 rs1245347700	1282	A>V		No	ClinGen gnomAD
CA337439858 rs1050808	1285	S>F		No	ClinGen Ensembl
rs753877149 CA10574732	1286	E>G		No	ClinGen ExAC gnomAD
rs780282455 CA10574731	1289	T>S		No	ClinGen ExAC gnomAD
CA414842566 rs1203425230	1293	R>G		No	ClinGen gnomAD
rs367572296 CA10574730	1293	R>Q		No	ClinGen ESP ExAC gnomAD
rs750708901 CA10574729	1299	R>C		No	ClinGen ExAC gnomAD
CA414842497 rs1230157091	1299	R>H		No	ClinGen gnomAD
CA414842486 rs763763717	1300	Q>P		No	ClinGen ExAC gnomAD
CA10574728 rs763763717	1300	Q>R		No	ClinGen ExAC gnomAD
rs1459345858 CA414842327	1315	T>I		No	ClinGen gnomAD
rs1423488604 CA414842309	1318	T>I		No	ClinGen gnomAD
rs776040782 CA10574722	1323	I>V		No	ClinGen ExAC gnomAD
CA414842235 rs1248622510	1326	G>D		No	ClinGen gnomAD
CA10574710 rs781449106	1341	G>E		No	ClinGen ExAC gnomAD
CA414841999 rs1166945534	1344	V>M		No	ClinGen gnomAD
rs1449158190 CA414841961	1347	P>L		No	ClinGen gnomAD
CA414841931 rs1390845365	1350	M>V		No	ClinGen gnomAD
rs1190646379 CA414841909	1351	A>V		No	ClinGen gnomAD
rs370740347 CA10574704	1359	E>D		No	ClinGen ESP ExAC gnomAD
CA10574705 rs753866467	1359	E>Q		No	ClinGen ExAC gnomAD
CA414841646 rs1393759714	1374	E>K		No	ClinGen Ensembl
rs750481044 CA10574702	1382	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1422069481 CA414841559	1383	L>M		No	ClinGen gnomAD
rs767292584 CA10574701	1387	M>V		No	ClinGen ExAC gnomAD
rs762202481 CA10574700	1388	M>I		No	ClinGen ExAC gnomAD
CA414841492 rs1182368335	1388	M>T		No	ClinGen gnomAD
TCGA novel	1394	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769191548 CA10574698	1403	I>V		No	ClinGen ExAC gnomAD
CA10574696 rs776130195	1409	A>S		No	ClinGen ExAC gnomAD
rs745970329 CA10574694	1413	P>L		No	ClinGen ExAC gnomAD
rs377408982 COSM1470013 CA337439815	1419	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA
CA337439809 rs369953595	1430	Q>H		No	ClinGen Ensembl
CA10574680 rs369468904	1433	R>G		No	ClinGen ESP ExAC gnomAD
CA10574679 rs763431050	1433	R>Q		No	ClinGen ExAC gnomAD
CA10574678 rs201122015	1436	S>I		No	ClinGen ExAC gnomAD
CA10574677 rs770335987	1437	R>Q		No	ClinGen ExAC gnomAD
CA414840904 rs1266713139	1437	R>W		No	ClinGen gnomAD
CA10574676 COSM1470012 rs745892280	1442	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10574675 rs776718151	1444	R>W		No	ClinGen ExAC gnomAD
CA10574674 rs771050756	1445	R>Q		No	ClinGen ExAC gnomAD
CA414840831 rs1367216953	1445	R>W		No	ClinGen gnomAD
rs1386551959 CA414840748	1452	R>K		No	ClinGen gnomAD
rs1158331588 CA414840729	1453	N>K		No	ClinGen gnomAD
CA10574672 rs778039265	1454	V>A		No	ClinGen ExAC gnomAD
rs1413878334 CA414840650	1460	Q>R		No	ClinGen gnomAD
rs1603545676 CA414840628	1462	L>F		No	ClinGen Ensembl
CA10574671 rs374766772	1464	S>*		No	ClinGen ESP ExAC
CA337439803 rs974845953	1468	R>W		No	ClinGen Ensembl
rs756107992 CA10574668	1478	R>*		No	ClinGen ExAC gnomAD
rs35681523 CA10574667	1478	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA10574666 rs767104385	1479	E>D		No	ClinGen ExAC gnomAD
rs767405452 CA10574665	1482	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs751241980 CA337439801	1488	D>E		No	ClinGen ExAC gnomAD
CA10574663 rs763818200	1489	R>C		No	ClinGen ExAC gnomAD
rs763157175 CA10574662	1489	R>H		No	ClinGen ExAC gnomAD
CA337439798 rs11549043	1499	D>Y		No	ClinGen Ensembl
CA414840197 rs1311997092	1500	H>R		No	ClinGen gnomAD
rs753133666 CA10574661	1508	Q>K		No	ClinGen ExAC gnomAD
CA10574659 rs760018135	1523	P>H		No	ClinGen ExAC gnomAD
rs1387001796 CA414839829	1531	L>F		No	ClinGen gnomAD
CA337439794 rs369802892	1533	Y>H		No	ClinGen ESP
rs776437349 CA10574658	1538	Q>H		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with Q9BY66

10 regional properties for Q9BY66

Type	Name	Position	InterPro Accession
domain	Zinc finger, PHD-type	731 - 789	IPR001965-1
domain	Zinc finger, PHD-type	851 - 907	IPR001965-2
domain	Tudor domain	917 - 974	IPR002999-1
domain	Tudor domain	975 - 1031	IPR002999-2
domain	JmjC domain	143 - 309	IPR003347
domain	JmjN domain	14 - 57	IPR003349
domain	Extended PHD (ePHD) domain	794 - 907	IPR034732
domain	Lysine-specific demethylase 4-like, Tudor domain	922 - 956	IPR040477-1
domain	Lysine-specific demethylase 4-like, Tudor domain	980 - 1014	IPR040477-2
domain	Lysine-specific demethylase 4B, first Tudor domain	919 - 972	IPR047483

Functions

		Description
EC Number	1.14.11.67	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone demethylase activity	Catalysis of the removal of a methyl group from a histone.
histone H3-methyl-lysine-4 demethylase activity	Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein.
histone H3-tri/di/monomethyl-lysine-4 demethylase activity	Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
metal ion binding	Binding to a metal ion.
nuclear androgen receptor binding	Binding to a nuclear androgen receptor.

4 GO annotations of biological process

Name	Definition
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
histone H3-K4 demethylation	The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
regulation of androgen receptor signaling pathway	Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
T cell antigen processing and presentation	The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O94953	KDM4B	Lysine-specific demethylase 4B	Homo sapiens (Human)	PR
O75164	KDM4A	Lysine-specific demethylase 4A	Homo sapiens (Human)	PR
Q62240	Kdm5d	Lysine-specific demethylase 5D	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEPGCDEFLP	PPECPVFEPS	WAEFQDPLGY	IAKIRPIAEK	SGICKIRPPA	DWQPPFAVEV
70	80	90	100	110	120
DNFRFTPRVQ	RLNELEAQTR	VKLNYLDQIA	KFWEIQGSSL	KIPNVERKIL	DLYSLSKIVI
130	140	150	160	170	180
EEGGYEAICK	DRRWARVAQR	LHYPPGKNIG	SLLRSHYERI	IYPYEMFQSG	ANHVQCNTHP
190	200	210	220	230	240
FDNEVKDKEY	KPHSIPLRQS	VQPSKFSSYS	RRAKRLQPDP	EPTEEDIEKH	PELKKLQIYG
250	260	270	280	290	300
PGPKMMGLGL	MAKDKDKTVH	KKVTCPPTVT	VKDEQSGGGN	VSSTLLKQHL	SLEPCTKTTM
310	320	330	340	350	360
QLRKNHSSAQ	FIDSYICQVC	SRGDEDDKLL	FCDGCDDNYH	IFCLLPPLPE	IPRGIWRCPK
370	380	390	400	410	420
CILAECKQPP	EAFGFEQATQ	EYSLQSFGEM	ADSFKSDYFN	MPVHMVPTEL	VEKEFWRLVS
430	440	450	460	470	480
SIEEDVTVEY	GADIHSKEFG	SGFPVSNSKQ	NLSPEEKEYA	TSGWNLNVMP	VLDQSVLCHI
490	500	510	520	530	540
NADISGMKVP	WLYVGMVFSA	FCWHIEDHWS	YSINYLHWGE	PKTWYGVPSL	AAEHLEEVMK
550	560	570	580	590	600
MLTPELFDSQ	PDLLHQLVTL	MNPNTLMSHG	VPVVRTNQCA	GEFVITFPRA	YHSGFNQGYN
610	620	630	640	650	660
FAEAVNFCTA	DWLPAGRQCI	EHYRRLRRYC	VFSHEELICK	MAAFPETLDL	NLAVAVHKEM
670	680	690	700	710	720
FIMVQEERRL	RKALLEKGVT	EAEREAFELL	PDDERQCIKC	KTTCFLSALA	CYDCPDGLVC
730	740	750	760	770	780
LSHINDLCKC	SSSRQYLRYR	YTLDELPTML	HKLKIRAESF	DTWANKVRVA	LEVEDGRKRS
790	800	810	820	830	840
FEELRALESE	ARERRFPNSE	LLQRLKNCLS	EVEACIAQVL	GLVSGQVARM	DTPQLTLTEL
850	860	870	880	890	900
RVLLEQMGSL	PCAMHQIGDV	KDVLEQVEAY	QAEAREALAT	LPSSPGLLRS	LLERGQQLGV
910	920	930	940	950	960
EVPEAHQLQQ	QVEQAQWLDE	VKQALAPSAH	RGSLVIMQGL	LVMGAKIASS	PSVDKARAEL
970	980	990	1000	1010	1020
QELLTIAERW	EEKAHFCLEA	RQKHPPATLE	AIIRETENIP	VHLPNIQALK	EALTKAQAWI
1030	1040	1050	1060	1070	1080
ADVDEIQNGD	HYPCLDDLEG	LVAVGRDLPV	GLEELRQLEL	QVLTAHSWRE	KASKTFLKKN
1090	1100	1110	1120	1130	1140
SCYTLLEVLC	PCADAGSDST	KRSRWMEKAL	GLYQCDTELL	GLSAQDLRDP	GSVIVAFKEG
1150	1160	1170	1180	1190	1200
EQKEKEGILQ	LRRTNSAKPS	PLAPSLMASS	PTSICVCGQV	PAGVGVLQCD	LCQDWFHGQC
1210	1220	1230	1240	1250	1260
VSVPHLLTSP	KPSLTSSPLL	AWWEWDTKFL	CPLCMRSRRP	RLETILALLV	ALQRLPVRLP
1270	1280	1290	1300	1310	1320
EGEALQCLTE	RAIGWQDRAR	KALASEDVTA	LLRQLAELRQ	QLQAKPRPEE	ASVYTSATAC
1330	1340	1350	1360	1370	1380
DPIREGSGNN	ISKVQGLLEN	GDSVTSPENM	APGKGSDLEL	LSSLLPQLTG	PVLELPEAIR
1390	1400	1410	1420	1430	1440
APLEELMMEG	DLLEVTLDEN	HSIWQLLQAG	QPPDLDRIRT	LLELEKFEHQ	GSRTRSRALE
1450	1460	1470	1480	1490	1500
RRRRRQKVDQ	GRNVENLVQQ	ELQSKRARSS	GIMSQVGREE	EHYQEKADRE	NMFLTPSTDH
1510	1520	1530
SPFLKGNQNS	LQHKDSGSSA	ACPSLMPLLQ	LSYSDEQQL