AiPD: Autoinhibited Protein Database

Q9BY19

Gene name	MS4A8 (4SPAN4, MS4A8B)
Protein name	Membrane-spanning 4-domains subfamily A member 8
Names	Four-span transmembrane protein 4, Membrane-spanning 4-domains subfamily A member 8B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83661
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

203-250 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

203-250 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BY19

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BY19-F1	Predicted				AlphaFoldDB

218 variants for Q9BY19

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM171898 CA380596556 rs1426906759	3	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM312950 CA380596564 rs1168380345 CA380596565	4	M>I	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1196400733 CA380596561	4	M>T		No	ClinGen TOPMed
TCGA novel	7	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1324974041 CA380596590	9	P>A		No	ClinGen TOPMed gnomAD
CA6025586 rs776863093	9	P>L	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1324974041 CA380596591	9	P>S		No	ClinGen TOPMed gnomAD
rs769797287 CA6025588	10	V>G		No	ClinGen ExAC gnomAD
TCGA novel	11	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1230100836 CA380596606	12	N>H		No	ClinGen gnomAD
rs1318788556 CA380596632	15	L>F		No	ClinGen TOPMed
CA6025591 rs762932701	16	V>M		No	ClinGen ExAC gnomAD
CA6025592 rs770893882	19	P>S		No	ClinGen ExAC gnomAD
CA380596660 rs1231408067	20	H>P		No	ClinGen TOPMed
CA6025593 rs758758486	21	N>S		No	ClinGen ExAC TOPMed gnomAD
CA380596670 rs1590951000	22	G>S		No	ClinGen Ensembl
rs778208143 CA222782877	24	P>A		No	ClinGen TOPMed
TCGA novel	25	V>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1590951007 CA380596695	26	T>P		No	ClinGen Ensembl
CA222782884 rs764484076	27	P>S		No	ClinGen Ensembl
CA380596745 rs1398774909	30	M>I		No	ClinGen TOPMed
CA380596741 rs1267065688	30	M>T		No	ClinGen gnomAD
TCGA novel	31	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6025595 rs767109802	31	S>Y		No	ClinGen ExAC gnomAD
CA6025596 rs183590907	33	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145052992 CA6025597	34	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA380596829 rs1490066290	37	P>A		No	ClinGen gnomAD
CA380596833 rs1365621729	37	P>Q		No	ClinGen TOPMed gnomAD
CA6025599 rs753395781	38	N>S		No	ClinGen ExAC gnomAD
CA380596845 rs753395781	38	N>T		No	ClinGen ExAC gnomAD
CA222782955 rs202135543	39	S>N		No	ClinGen Ensembl
rs143047257 CA6025600	41	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs143047257 CA380596888	41	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025605 rs143555218	42	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	42	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6025606 rs748309290	43	V>I		No	ClinGen ExAC gnomAD
COSM929267 CA380596942 rs1225836566	45	L>P	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs769987023 CA380596948	46	V>F		No	ClinGen ExAC TOPMed gnomAD
CA6025607 rs769987023	46	V>I		No	ClinGen ExAC TOPMed gnomAD
CA380596990 rs1221886351	49	N>K		No	ClinGen gnomAD
rs1486982433 CA380597008	51	P>S		No	ClinGen gnomAD
CA380597021 rs1275765118	52	S>G		No	ClinGen TOPMed
CA6025608 COSM1215553 rs375232214	55	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1448246623 CA380597086	56	N>K		No	ClinGen TOPMed
COSM415520 rs148191741 CA6025610	57	V>M	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA380597120 rs1385808197	59	G>A		No	ClinGen gnomAD
rs1443436430 CA380597124	60	Q>*		No	ClinGen gnomAD
rs1164216920 CA380597141	61	P>T		No	ClinGen gnomAD
CA6025611 rs774307302	63	Q>R		No	ClinGen ExAC
CA6025612 rs759256994	68	E>G		No	ClinGen ExAC gnomAD
rs775413798 CA6025615	73	G>E		No	ClinGen ExAC gnomAD
CA380597292 rs1287966512	73	G>R		No	ClinGen gnomAD
TCGA novel	74	A>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764744158 CA6025637	74	A>T		No	ClinGen ExAC TOPMed gnomAD
rs987829871 CA222784040	77	I>M		No	ClinGen TOPMed
CA222784047 rs919792697	78	I>N		No	ClinGen Ensembl
rs931152285 CA222784050	79	I>T		No	ClinGen TOPMed
CA380598009 rs1480289436	80	G>S		No	ClinGen gnomAD
CA222784061 rs17852124	83	H>R		No	ClinGen Ensembl
CA6025639 rs200488492	84	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6025642 rs145301373	85	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1264103818 CA380598122	86	L>F		No	ClinGen Ensembl
CA380598128 rs1426650008	86	L>P		No	ClinGen gnomAD
CA380598137 rs754004266	87	G>A		No	ClinGen ExAC gnomAD
CA6025644 rs754004266	87	G>D		No	ClinGen ExAC gnomAD
CA6025643 rs138969504	87	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025646 rs142107924	89	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1213893118 CA380598194	90	M>T		No	ClinGen TOPMed gnomAD
rs976789781 CA222784111	90	M>V		No	ClinGen TOPMed gnomAD
rs572019233 CA6025647 COSM1676070	91	A>V	central_nervous_system haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA380598257 rs1590952163	93	V>G		No	ClinGen Ensembl
VAR_053523 CA6025650 CA6025651 rs35956659	95	V>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1565051180 CA380598323	98	Y>*		No	ClinGen Ensembl
rs1439385853 CA380598315	98	Y>H		No	ClinGen TOPMed
rs1010275393 CA222784136	99	L>M		No	ClinGen gnomAD
rs1217568795 CA380598332	99	L>P		No	ClinGen gnomAD
TCGA novel	100	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380598340 rs1464724792	100	S>P		No	ClinGen TOPMed
CA380598358 rs1475968855	101	I>V		No	ClinGen gnomAD
rs149636295 CA6025655	103	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM118038 rs144254483 CA6025656	104	Y>*	ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	104	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768046843 CA6025658	105	G>R		No	ClinGen ExAC gnomAD
rs1365103071 CA380598432	106	G>R		No	ClinGen gnomAD
rs1565051202 CA380598436	106	G>V		No	ClinGen Ensembl
rs1403811905 CA380598444	107	F>L		No	ClinGen gnomAD
CA380598480 rs1171652496	109	F>L		No	ClinGen TOPMed
TCGA novel	109	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762178932 CA222784159	110	W>C		No	ClinGen Ensembl
CA6025659 rs775913216	110	W>L		No	ClinGen ExAC gnomAD
CA380598485 rs1455560107	110	W>R		No	ClinGen TOPMed
rs1345547587 CA380598503	111	G>*		No	ClinGen gnomAD
CA380598511 rs1254917581	112	G>S		No	ClinGen TOPMed
CA380598535 rs1437381598	113	L>F		No	ClinGen TOPMed
rs1461702963 CA380598529	113	L>S		No	ClinGen TOPMed gnomAD
rs1295255155 CA380598547	114	W>*		No	ClinGen gnomAD
rs941234997 CA222784163	114	W>G		No	ClinGen TOPMed
CA222785660 rs912007173	116	I>V		No	ClinGen TOPMed gnomAD
rs1326146779 CA380599134	120	S>C		No	ClinGen gnomAD
TCGA novel	120	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140709117 CA6025688	123	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs780966264 CA6025689	125	A>T		No	ClinGen ExAC gnomAD
CA6025690 rs752555528	125	A>V		No	ClinGen ExAC gnomAD
CA380599176 rs1225792659	127	N>Y		No	ClinGen TOPMed
TCGA novel	128	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380599191 rs1590953754	128	Q>H		No	ClinGen Ensembl
rs1346691776 CA380599189	128	Q>L		No	ClinGen TOPMed
CA222785684 rs752189816	129	P>S		No	ClinGen TOPMed gnomAD
rs144721499 CA6025691	130	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs777499721 CA6025692	133	C>F		No	ClinGen ExAC gnomAD
rs1249310065 CA380599219	133	C>R		No	ClinGen gnomAD
rs777499721 CA380599221	133	C>Y		No	ClinGen ExAC gnomAD
CA380599227 rs1157303958	134	L>Q		No	ClinGen gnomAD
CA6025708 rs752522397	136	S>C		No	ClinGen ExAC gnomAD
rs756068264 CA6025709	138	S>N		No	ClinGen ExAC gnomAD
rs1290922278 CA380599367	138	S>R		No	ClinGen TOPMed
CA380599386 rs1379625690	140	G>S		No	ClinGen gnomAD
CA380599393 rs1395112307	140	G>V		No	ClinGen gnomAD
rs867334851 CA222786447	141	L>F		No	ClinGen gnomAD
rs1304535142 CA380599417	142	N>K		No	ClinGen gnomAD
rs748203143 CA222786449	143	I>V		No	ClinGen Ensembl
CA380599433 rs147472289	144	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025711 rs147472289	144	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025712 rs567451277	145	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs907259071 CA222786459	145	S>N		No	ClinGen TOPMed
CA380599452 rs1329782008	146	A>S		No	ClinGen gnomAD
rs1219801986 CA380599468	147	I>M		No	ClinGen TOPMed
CA380599465 rs1271335826	147	I>T		No	ClinGen gnomAD
rs1002964494 CA222786463	149	S>F		No	ClinGen TOPMed
rs1565052881 CA380599505	151	V>F		No	ClinGen Ensembl
rs1002389014 CA222786467	152	G>A		No	ClinGen TOPMed gnomAD
CA380599517 rs1002389014	152	G>E		No	ClinGen TOPMed gnomAD
CA380599520 rs1438033850	153	V>I		No	ClinGen TOPMed
CA6025715 rs757779271	154	I>M		No	ClinGen ExAC gnomAD
rs745414264 CA6025714	154	I>T		No	ClinGen ExAC gnomAD
CA222786472 rs960670603	155	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1327796421 CA380599568	157	I>T		No	ClinGen TOPMed
CA380599588 rs1463831896	159	D>G		No	ClinGen TOPMed
rs530030122 CA6025717	159	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs530030122 CA380599584	159	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs987737731 CA222786495	163	P>A		No	ClinGen gnomAD
rs199567916 CA6025719	163	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs182001591 CA222786500	164	H>Q		No	ClinGen 1000Genomes TOPMed
CA380599653 rs1423605597	165	P>S		No	ClinGen gnomAD
TCGA novel	166	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6025720 rs773486448	166	Y>F		No	ClinGen ExAC gnomAD
rs1384299773 CA380599686	167	A>D		No	ClinGen TOPMed gnomAD
CA380599718 rs1181363672	169	P>L		No	ClinGen TOPMed
rs780581740 CA6025724	170	D>E		No	ClinGen ExAC TOPMed gnomAD
rs201478139 CA6025722	170	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6025723 rs201478139	170	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1244303528 CA380599743	172	Y>N		No	ClinGen gnomAD
rs139677781 CA222786522	173	P>A		No	ClinGen ESP TOPMed gnomAD
TCGA novel	173	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139677781 CA380599757	173	P>S		No	ClinGen ESP TOPMed gnomAD
rs764071842 CA6025728	175	A>G		No	ClinGen ExAC gnomAD
CA6025726 rs775637715	175	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6025727 rs775637715	175	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6025729 rs753655631	177	G>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	177	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6025730 rs757007792	177	G>V		No	ClinGen ExAC gnomAD
rs752227539 CA6025773	179	N>K		No	ClinGen ExAC gnomAD
CA6025775 rs371762860	180	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA380600557 rs1343383898 COSM543976	180	P>L	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs371762860 CA6025774	180	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025777 COSM689400 rs758725009	183	A>V	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	185	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774047809 CA222789554	185	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs560863829 CA6025781	187	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6025783 rs769742177	188	L>P		No	ClinGen ExAC gnomAD
rs762657573 CA6025785	190	V>L		No	ClinGen ExAC gnomAD
rs1290487923 CA380600750	191	F>L		No	ClinGen gnomAD
TCGA novel	192	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147400889 CA6025786	195	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA222789604 rs267603057	196	F>L		No	ClinGen Ensembl
CA380600846 rs1294756554	197	G>D		No	ClinGen gnomAD
CA222789610 rs35356499	198	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	198	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6025788 COSM929276 rs149745158	199	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	200	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745512206 CA222789614	200	C>S		No	ClinGen Ensembl
rs200663288 CA6025789	200	C>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6025792 rs201465289	201	A>P		No	ClinGen ExAC TOPMed gnomAD
CA6025791 rs201465289	201	A>S		No	ClinGen ExAC TOPMed gnomAD
CA222789618 rs201465289	201	A>T		No	ClinGen ExAC TOPMed gnomAD
CA380600915 rs1372402116	201	A>V		No	ClinGen TOPMed
rs1219833252 CA380600967	204	H>D		No	ClinGen gnomAD
rs1386685992 CA380600991	205	F>L		No	ClinGen Ensembl
CA6025793 rs750886877	205	F>S		No	ClinGen ExAC gnomAD
rs758819733 CA6025794	210	V>A		No	ClinGen ExAC gnomAD
rs1465733845 CA380601072	210	V>F		No	ClinGen gnomAD
CA6025797 rs755242221	212	C>*		No	ClinGen ExAC gnomAD
rs751837079 CA6025796	212	C>S		No	ClinGen ExAC TOPMed gnomAD
rs781342837 CA6025798	213	Q>P		No	ClinGen ExAC gnomAD
CA380601164 TCGA novel rs756117147	215	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs1178196727 CA380601171	216	N>D		No	ClinGen gnomAD
rs777581334 CA6025801	216	N>S		No	ClinGen ExAC gnomAD
rs1207504383 CA380601240	217	V>L		No	ClinGen gnomAD
rs1207504383 CA380601238	217	V>M		No	ClinGen gnomAD
rs776252839 CA6025830	218	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1424790781 CA380601278	219	V>I		No	ClinGen Ensembl
rs761178094 CA6025831	220	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1317267346 CA380601345	223	N>D		No	ClinGen TOPMed
CA6025833 rs146666911	225	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6025834 rs759903573	228	N>I		No	ClinGen ExAC gnomAD
rs767924404 CA6025835	229	P>L		No	ClinGen ExAC gnomAD
CA380601455 rs1245425172	230	V>M		No	ClinGen gnomAD
rs1411183112 CA380601475	232	T>S		No	ClinGen gnomAD
rs1289846429 CA380601485	233	P>L		No	ClinGen gnomAD
CA380601482 rs1369574290	233	P>S		No	ClinGen gnomAD
CA6025838 rs761009887	234	E>G		No	ClinGen ExAC gnomAD
CA6025839 rs764177475	235	P>L		No	ClinGen ExAC TOPMed gnomAD
CA222789798 rs960118641	235	P>S		No	ClinGen TOPMed
rs375920027 CA6025841	237	T>I		No	ClinGen ESP ExAC
CA6025842 rs778923717	240	P>S		No	ClinGen ExAC gnomAD
CA380601546 rs750444624	241	S>N		No	ClinGen ExAC gnomAD
CA6025843 rs750444624	241	S>T		No	ClinGen ExAC gnomAD
rs1275554276 CA380601556	242	Y>*		No	ClinGen gnomAD

No associated diseases with Q9BY19

No regional properties for Q9BY19

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BY19

Functions

		Description
EC Number
Subcellular Localization	Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MNSMTSAVPV	ANSVLVVAPH	NGYPVTPGIM	SHVPLYPNSQ	PQVHLVPGNP	PSLVSNVNGQ
70	80	90	100	110	120
PVQKALKEGK	TLGAIQIIIG	LAHIGLGSIM	ATVLVGEYLS	ISFYGGFPFW	GGLWFIISGS
130	140	150	160	170	180
LSVAAENQPY	SYCLLSGSLG	LNIVSAICSA	VGVILFITDL	SIPHPYAYPD	YYPYAWGVNP
190	200	210	220	230	240
GMAISGVLLV	FCLLEFGIAC	ASSHFGCQLV	CCQSSNVSVI	YPNIYAANPV	ITPEPVTSPP

SYSSEIQANK