AiPD: Autoinhibited Protein Database

Q9BTX1

Gene name	NDC1 (TMEM48)
Protein name	Nucleoporin NDC1
Names	hNDC1, Transmembrane protein 48
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55706
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

359-534 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

359-534 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9BTX1

Entry ID	Method	Resolution	Chain	Position	Source
7R5J	EM	5000 A	E0/E1	1-674	PDB
7R5K	EM	1200 A	E0/E1	1-674	PDB
AF-Q9BTX1-F1	Predicted				AlphaFoldDB

476 variants for Q9BTX1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000844758 CA340411403 rs1570193658	369	C>Y	Global developmental delay [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs1166019480 CA340416186	2	A>T		No	ClinGen gnomAD
CA862109 rs563958473	4	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA22663668 rs897196827	5	V>A		No	ClinGen TOPMed gnomAD
rs1263441723 CA340416169	5	V>L		No	ClinGen TOPMed gnomAD
CA340416170 rs1263441723	5	V>M		No	ClinGen TOPMed gnomAD
CA340416149 rs1323318209	8	P>H		No	ClinGen TOPMed gnomAD
rs1323318209 CA340416147	8	P>L		No	ClinGen TOPMed gnomAD
rs1222154233 CA340416150	8	P>S		No	ClinGen gnomAD
CA22663662 rs572040816	10	A>P		No	ClinGen 1000Genomes
CA340416134 rs1341424656	10	A>V		No	ClinGen gnomAD
CA340416131 rs1403180918	11	G>C		No	ClinGen gnomAD
CA340416125 rs1390027820	12	R>K		No	ClinGen gnomAD
rs1266882267 CA340416115	13	S>L		No	ClinGen TOPMed
CA340416119 rs1294650296	13	S>P		No	ClinGen gnomAD
CA22663658 rs1039544081	14	R>Q		No	ClinGen TOPMed
rs1459859746 CA340416113	14	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA862105 rs767468558	15	D>E		No	ClinGen ExAC TOPMed gnomAD
rs7512625 CA862106	15	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1167778888 CA340416098	16	I>M		No	ClinGen TOPMed
rs1430311505 CA340416103	16	I>V		No	ClinGen TOPMed
rs1478352937 CA340416097	17	L>M		No	ClinGen gnomAD
rs1423908413 CA340416095	17	L>P		No	ClinGen TOPMed gnomAD
rs1423908413 CA340416094	17	L>R		No	ClinGen TOPMed gnomAD
rs749799534 CA862090	20	V>I		No	ClinGen ExAC gnomAD
CA862089 rs780038604	21	L>W		No	ClinGen ExAC gnomAD
rs202217135 CA862087 CA862086	23	W>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340415960 rs1570245187	24	R>K		No	ClinGen Ensembl
TCGA novel	24	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA22662257 rs993879153	25	I>T		No	ClinGen TOPMed gnomAD
CA340415948 rs1344291075	26	V>A		No	ClinGen TOPMed
TCGA novel	26	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA22662253 rs199526095	26	V>I		No	ClinGen ESP
CA340415926 rs1397776009	29	I>M		No	ClinGen TOPMed
CA862083 rs576421559	36	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA862082 rs147722125	38	I>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA862080 rs765031899	40	T>A		No	ClinGen ExAC gnomAD
CA340415852 rs1283001749	41	T>R		No	ClinGen TOPMed
rs759121257 RCV000970695 CA862079	43	F>L		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA340415837 rs776056249	44	I>L		No	ClinGen ExAC TOPMed gnomAD
rs766036185 CA862077	44	I>T		No	ClinGen ExAC gnomAD
CA862078 rs776056249	44	I>V		No	ClinGen ExAC TOPMed gnomAD
rs760310220 CA862076	47	S>R		No	ClinGen ExAC TOPMed gnomAD
CA862075 rs774766049	49	I>M		No	ClinGen ExAC gnomAD
CA340415799 rs1158004039	49	I>T		No	ClinGen gnomAD
CA22662219 rs1050289145	51	L>F		No	ClinGen TOPMed
CA22662215 rs768979369	53	H>L		No	ClinGen ExAC TOPMed gnomAD
rs1185232454 CA340415771	53	H>Q		No	ClinGen gnomAD
CA862074 rs768979369	53	H>R		No	ClinGen ExAC TOPMed gnomAD
CA862073 rs749809313	54	P>L		No	ClinGen ExAC TOPMed gnomAD
CA340415767 rs1441567574	54	P>S		No	ClinGen gnomAD
CA862071 rs41313377	55	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA862072 rs776087410	55	I>V		No	ClinGen ExAC gnomAD
CA862070 rs745972331	56	Q>R		No	ClinGen ExAC gnomAD
CA340415752 rs1557593323	57	W>R		No	ClinGen Ensembl
rs554272928 CA862069	59	S>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1242220501 CA340415693	60	D>V		No	ClinGen gnomAD
CA862054 rs548894964	62	F>C		No	ClinGen 1000Genomes ExAC gnomAD
CA862055 rs763380008	62	F>L		No	ClinGen ExAC gnomAD
CA862052 rs746354094	66	Y>C		No	ClinGen ExAC gnomAD
CA340415634 rs1557592091	66	Y>D		No	ClinGen Ensembl
CA340415623 rs1198766677	67	S>G		No	ClinGen TOPMed
rs767668725 CA22660708	69	Y>C		No	ClinGen TOPMed
CA340415539 rs1479435707	71	I>M		No	ClinGen TOPMed
rs771109347 CA862050	72	F>L		No	ClinGen ExAC gnomAD
CA862051 rs776889041	72	F>S		No	ClinGen ExAC gnomAD
CA862048 rs778167892	75	L>V		No	ClinGen ExAC TOPMed gnomAD
CA862046 rs747992238	80	V>I		No	ClinGen ExAC gnomAD
rs1164844207 CA340415330	84	I>R		No	ClinGen gnomAD
rs778562994 CA862044	88	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1004112842 CA22660678	90	E>G		No	ClinGen TOPMed
CA862043 rs755012639	91	F>I		No	ClinGen ExAC gnomAD
rs199637950 CA862042	92	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA862041 rs116279146	93	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749035140 CA862023	94	V>A		No	ClinGen ExAC TOPMed gnomAD
rs779998354 CA862022	96	P>L		No	ClinGen ExAC gnomAD
CA340413905 rs1248979652	99	P>R		No	ClinGen gnomAD
rs780561702 CA862019	102	R>T		No	ClinGen ExAC gnomAD
CA340413883 rs1200890540	103	L>I		No	ClinGen gnomAD
rs1414676750 CA340413881	103	L>Q		No	ClinGen gnomAD
CA862017 rs61751026	106	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA862015 rs760006725	106	I>M		No	ClinGen ExAC gnomAD
CA862016 rs61751026	106	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	108	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340413847 rs1345032456	109	I>N		No	ClinGen TOPMed gnomAD
rs1345032456 CA340413846	109	I>T		No	ClinGen TOPMed gnomAD
rs754183651 CA862014	109	I>V		No	ClinGen ExAC
CA22658418 rs369521412	110	I>V		No	ClinGen ESP TOPMed
CA862013 rs767010598	116	M>L		No	ClinGen ExAC gnomAD
CA340413798 rs1416002368	116	M>T		No	ClinGen TOPMed
CA862012 rs375742323	117	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs368557375 CA862010	117	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs375742323 CA862011	117	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs762145922 CA862009	118	S>L		No	ClinGen ExAC gnomAD
TCGA novel	121	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA22658413 rs868505816	121	H>Q		No	ClinGen Ensembl
rs779810302 CA862005	124	M>R		No	ClinGen ExAC gnomAD
rs757239698 CA862006	124	M>V		No	ClinGen ExAC gnomAD
rs1381462827 CA340413735	126	M>V		No	ClinGen gnomAD
CA862004 rs769789336	127	V>M		No	ClinGen ExAC TOPMed gnomAD
rs780801495 CA862002	128	M>I		No	ClinGen ExAC TOPMed gnomAD
CA862003 rs745759834	128	M>L		No	ClinGen ExAC gnomAD
CA862001 rs756737481	131	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA340413693 rs1442523214	132	A>T		No	ClinGen TOPMed gnomAD
rs751036886 CA340413686	133	A>P		No	ClinGen ExAC TOPMed gnomAD
rs751036886 CA862000	133	A>S		No	ClinGen ExAC TOPMed gnomAD
rs751036886 CA340413687	133	A>T		No	ClinGen ExAC TOPMed gnomAD
CA340413673 rs1237296234	135	I>T		No	ClinGen gnomAD
rs1013025245 CA22658395	135	I>V		No	ClinGen TOPMed gnomAD
CA340413664 rs1352972249	137	Q>K		No	ClinGen gnomAD
CA340413659 rs1235544858	137	Q>L		No	ClinGen gnomAD
rs1054687190 CA22658391	138	G>D		No	ClinGen Ensembl
CA861999 rs777291505	140	Y>H		No	ClinGen ExAC gnomAD
CA861998 rs141204999	141	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200547658 CA861997	144	V>L		No	ClinGen ExAC gnomAD
rs1040275375 CA22658377	146	P>R		No	ClinGen TOPMed
TCGA novel	147	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449082990 CA340413582	149	G>D		No	ClinGen gnomAD
CA861995 rs375468870	150	T>P		No	ClinGen ESP ExAC gnomAD
CA861975 VAR_026388 rs17849721	154	G>D		No	ClinGen UniProt ExAC dbSNP gnomAD
CA861974 rs767915338	155	S>R		No	ClinGen ExAC gnomAD
CA340413524 rs1187741257	156	P>A		No	ClinGen TOPMed gnomAD
rs1221579877 CA340413518	157	A>S		No	ClinGen TOPMed
rs757726463 CA861973	158	A>T		No	ClinGen ExAC TOPMed gnomAD
rs144318786 CA861972	158	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA861970 rs763209170	161	C>S		No	ClinGen ExAC gnomAD
rs1297874207 CA340413454	166	H>L		No	ClinGen gnomAD
CA861967 rs759251141	166	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA340413443 rs1385138531	168	F>L		No	ClinGen gnomAD
TCGA novel	169	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776425575 CA861966	170	L>I		No	ClinGen ExAC TOPMed gnomAD
CA861965 rs770828109	172	T>A		No	ClinGen ExAC gnomAD
TCGA novel	173	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340413406 rs1398508311	174	A>G		No	ClinGen gnomAD
CA861964 rs151303092	174	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1170374017 CA340413389	176	M>I		No	ClinGen gnomAD
CA861963 rs772892329	180	Y>C		No	ClinGen ExAC gnomAD
CA861962 rs771689510	181	S>N		No	ClinGen ExAC
rs1430888690 CA340413347	182	L>F		No	ClinGen TOPMed gnomAD
rs1430888690 CA340413345	182	L>V		No	ClinGen TOPMed gnomAD
CA340413326 rs1469673213	183	L>P		No	ClinGen TOPMed gnomAD
CA340413313 rs1456306650	184	Y>C		No	ClinGen TOPMed
rs148809606 CA861957	187	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757744383 CA861956	188	N>S		No	ClinGen ExAC gnomAD
rs1041306386 CA22657535	190	N>D		No	ClinGen gnomAD
rs943647334 CA22657523	190	N>S		No	ClinGen TOPMed gnomAD
CA861955 rs374201897	191	Y>C		No	ClinGen ESP ExAC gnomAD
rs1331167903 CA340413134	195	P>R		No	ClinGen gnomAD
rs778202878 CA861953	196	I>M		No	ClinGen ExAC gnomAD
rs944011011 CA22657515	196	I>V		No	ClinGen Ensembl
rs780758332 CA22657510	197	I>V		No	ClinGen Ensembl
rs1275923184 CA340413089	198	Q>H		No	ClinGen TOPMed
CA861933 rs778254143	199	Q>R		No	ClinGen ExAC gnomAD
CA340411940 rs1190160741	200	Y>C		No	ClinGen TOPMed gnomAD
CA340411925 rs1170529483	201	K>R		No	ClinGen TOPMed
TCGA novel	202	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA22655236 rs1009687150	202	F>L		No	ClinGen TOPMed
rs758842714 CA861932	204	R>C		No	ClinGen ExAC TOPMed gnomAD
CA861931 rs202236360	204	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA340411825 rs1390272312	208	S>T		No	ClinGen TOPMed
rs1244494651 CA340411737	213	V>G		No	ClinGen gnomAD
rs754073884 CA861928	215	H>Y		No	ClinGen ExAC gnomAD
CA340411699 rs1293453273	216	S>N		No	ClinGen gnomAD
CA22655211 rs769467721	217	C>F		No	ClinGen Ensembl
rs936700121 CA22655196	217	C>W		No	ClinGen TOPMed
rs769467721 CA22655214	217	C>Y		No	ClinGen Ensembl
CA861927 rs766466188	224	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1265727798 CA340411591	225	R>G		No	ClinGen TOPMed
CA340411562 rs1469953989	227	F>L		No	ClinGen TOPMed gnomAD
rs1207653786 CA340411543	229	I>T		No	ClinGen TOPMed
CA22655172 rs986786255	230	L>S		No	ClinGen Ensembl
CA22655163 rs905097399	232	Y>F		No	ClinGen TOPMed gnomAD
rs1423163444 CA340410099	235	G>A		No	ClinGen TOPMed gnomAD
rs1423163444 CA340410103	235	G>D		No	ClinGen TOPMed gnomAD
CA340410078 rs1168630407	236	Y>C		No	ClinGen gnomAD
CA340410061 rs1255612978	237	I>S		No	ClinGen TOPMed
CA340410067 rs1476393537	237	I>V		No	ClinGen gnomAD
CA861903 rs751537502	240	A>G		No	ClinGen ExAC TOPMed gnomAD
rs767576699 CA861902	241	W>R		No	ClinGen ExAC TOPMed gnomAD
rs762527996 CA861901	244	T>I		No	ClinGen ExAC gnomAD
rs773603921 CA861897	246	M>I		No	ClinGen ExAC gnomAD
CA340409910 rs759180095	246	M>R		No	ClinGen ExAC gnomAD
rs759180095 CA861898	246	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA861899 rs140272518	246	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	248	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340409819 rs1570208830	250	I>T		No	ClinGen Ensembl
CA340409801 rs1557581652	251	D>A		No	ClinGen Ensembl
CA340409582 rs1305444328	252	E>D		No	ClinGen gnomAD
rs765980814 CA22650350	254	V>A		No	ClinGen ExAC TOPMed gnomAD
rs765980814 CA340409559	254	V>D		No	ClinGen ExAC TOPMed gnomAD
rs565513140 CA861879	254	V>F		No	ClinGen ExAC TOPMed gnomAD
rs765980814 CA861878	254	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1280389837 CA340409548	255	H>R		No	ClinGen gnomAD
CA861877 rs762246216	257	P>L		No	ClinGen ExAC TOPMed gnomAD
CA861875 rs769264092	258	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1435347733 CA340409473	261	V>A		No	ClinGen gnomAD
CA861874 rs201129316	262	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA340409462 rs1361343346	262	S>N		No	ClinGen TOPMed
CA861873 rs139068522	263	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs139068522 CA340409444	263	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781569025 COSM233605 CA861870	268	S>L	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs781569025 CA340409382	268	S>W		No	ClinGen ExAC TOPMed gnomAD
CA861868 rs372200205	270	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA861865 rs745847402	272	H>R		No	ClinGen ExAC TOPMed gnomAD
CA861866 rs144862626	272	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs897947981 CA22650331	276	C>W		No	ClinGen Ensembl
CA861864 rs778777100	277	G>D		No	ClinGen ExAC gnomAD
CA861862 rs766036287	281	L>M		No	ClinGen ExAC gnomAD
CA861861 rs766036287	281	L>V		No	ClinGen ExAC gnomAD
rs138233326 CA861860 COSM910802	282	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA861858 rs764336913	285	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	285	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340409159 rs1357405170	286	V>A		No	ClinGen gnomAD
CA861857 rs763565846	288	W>R		No	ClinGen ExAC TOPMed gnomAD
rs776170347 CA861856	289	I>L		No	ClinGen ExAC gnomAD
rs759701745 CA861854	291	F>L		No	ClinGen ExAC TOPMed gnomAD
rs148955439 CA861852	294	Y>C		No	ClinGen ESP ExAC gnomAD
CA340409095 rs1475265517	296	T>S		No	ClinGen TOPMed gnomAD
CA340407889 rs1256328275	298	A>V		No	ClinGen gnomAD
CA861831 rs773341233	299	H>L		No	ClinGen ExAC TOPMed gnomAD
rs747955631 CA861829	303	V>I		No	ClinGen ExAC TOPMed gnomAD
CA861828 rs774122813	305	P>L		No	ClinGen ExAC gnomAD
CA340407724 rs1431616960	306	P>S		No	ClinGen gnomAD
CA22649685 rs1014355811	308	A>V		No	ClinGen TOPMed
CA861826 rs376309632	309	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA22649684 rs201022129	310	G>R		No	ClinGen TOPMed gnomAD
rs1302091161 CA340407600	312	D>A		No	ClinGen TOPMed
CA861824 rs145758782	314	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA340407380 rs1393095342	321	S>G		No	ClinGen TOPMed
rs756920484 CA861821	321	S>R		No	ClinGen ExAC gnomAD
rs931087415 CA22649651	322	N>S		No	ClinGen TOPMed gnomAD
rs753179579 CA861820	323	P>L		No	ClinGen ExAC gnomAD
rs562850670 CA861819	324	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1248707258 CA340407284	325	P>A		No	ClinGen gnomAD
rs151124002 CA861817	325	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs151124002 CA340407268	325	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs151124002 CA861818	325	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	326	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1208802673 CA340407248	326	I>T		No	ClinGen gnomAD
rs1347878042 CA340407202	328	K>E		No	ClinGen gnomAD
CA22670332 rs376969911	329	Y>H		No	ClinGen ESP
TCGA novel	332	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	333	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340411843 rs1312926886	334	D>E		No	ClinGen TOPMed gnomAD
CA340411824 rs764262039	336	M>K		No	ClinGen ExAC gnomAD
CA861786 rs751803285	336	M>L		No	ClinGen ExAC gnomAD
rs764262039 CA861785	336	M>T		No	ClinGen ExAC gnomAD
CA340411794 rs1365775210	339	S>A		No	ClinGen gnomAD
CA340411796 rs1365775210	339	S>P		No	ClinGen gnomAD
CA861783 rs775341175	344	S>P		No	ClinGen ExAC gnomAD
rs1474985084 CA340411724	345	R>G		No	ClinGen gnomAD
rs373565166 CA861782	345	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1190136021 CA340411696	347	Q>R		No	ClinGen gnomAD
rs759485673 CA861781	348	E>A		No	ClinGen ExAC TOPMed gnomAD
rs1232669879 CA340411675	348	E>D		No	ClinGen TOPMed
rs1206100831 CA340411669	349	V>F		No	ClinGen gnomAD
rs1353221909 CA340411653	350	F>L		No	ClinGen gnomAD
rs776049255 CA861780	352	L>H		No	ClinGen ExAC TOPMed gnomAD
CA340411639 rs1269667600	352	L>I		No	ClinGen gnomAD
rs770583868 CA861779	353	S>I		No	ClinGen ExAC gnomAD
CA340411613 rs770583868	353	S>N		No	ClinGen ExAC gnomAD
rs746474863 CA861778	354	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs536854518 CA861771	357	G>E		No	ClinGen ExAC TOPMed gnomAD
CA22668496 rs576246254	358	H>Y		No	ClinGen Ensembl
rs140153118 CA861769	361	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1194472334 CA340411444	363	T>A		No	ClinGen gnomAD
CA340411445 rs1194472334	363	T>P		No	ClinGen gnomAD
rs751580134 CA861768	364	A>G		No	ClinGen ExAC gnomAD
rs751580134 CA340411436	364	A>V		No	ClinGen ExAC gnomAD
CA340411421 rs1251578772	367	R>G		No	ClinGen gnomAD
rs1014798553 CA340411414	368	E>K		No	ClinGen Ensembl
rs1014798553 CA22668449	368	E>Q		No	ClinGen Ensembl
CA22668429 rs200098090	370	L>F		No	ClinGen Ensembl
rs752475168 CA861765	371	N>S		No	ClinGen ExAC TOPMed gnomAD
CA340411360 rs1211125967	373	L>S		No	ClinGen gnomAD
CA340411345 rs1261080350	374	N>S		No	ClinGen gnomAD
rs765055001 CA861764	375	G>S		No	ClinGen ExAC TOPMed gnomAD
CA340411318 rs1570193584	376	M>V		No	ClinGen Ensembl
CA22668407 rs1014146065	377	T>I		No	ClinGen gnomAD
TCGA novel	378	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1177983836 CA340411288	378	Q>R		No	ClinGen TOPMed
rs1367250174 CA340411268	381	I>V		No	ClinGen gnomAD
CA340411261 rs1301061379	382	L>V		No	ClinGen gnomAD
CA340411252 rs771920754	383	Y>C		No	ClinGen ExAC gnomAD
rs771920754 CA861758	383	Y>F		No	ClinGen ExAC gnomAD
rs1395506197 CA340411255	383	Y>H		No	ClinGen gnomAD
CA340411228 rs1408304848	386	A>V		No	ClinGen gnomAD
CA861756 rs780332596	389	T>A		No	ClinGen ExAC gnomAD
CA861755 rs770217612	389	T>M		No	ClinGen ExAC gnomAD
rs905804282 CA22668382	391	G>R		No	ClinGen TOPMed
rs757745763 CA861752	393	V>L		No	ClinGen ExAC gnomAD
CA340411144 rs1280314379	396	S>F		No	ClinGen TOPMed
rs372774650 CA861747	399	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs752982451 CA861748	399	V>L		No	ClinGen ExAC gnomAD
rs1227494012 CA340411106	400	E>K		No	ClinGen Ensembl
rs144487640 CA861746	400	E>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA340411081 rs1281168485	402	K>E		No	ClinGen TOPMed
CA861745 rs753517346	406	S>Y		No	ClinGen ExAC gnomAD
CA340411015 rs1344230523	407	P>L		No	ClinGen gnomAD
rs1338621325 CA340410229	408	E>V		No	ClinGen Ensembl
rs755144525 CA861727	410	T>A		No	ClinGen ExAC gnomAD
rs753756619 CA861726	411	A>D		No	ClinGen ExAC gnomAD
rs766250009 CA861725	412	F>V		No	ClinGen ExAC gnomAD
CA22665962 rs372529905	413	Q>H		No	ClinGen ESP TOPMed
CA340410036 rs1557575126	418	S>I		No	ClinGen Ensembl
CA340410021 rs1406817899	419	Q>R		No	ClinGen gnomAD
TCGA novel rs1343346851 CA340409995	420	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs767523513 CA861721	420	M>T		No	ClinGen ExAC TOPMed gnomAD
CA340409985 rs1473348388	421	P>R		No	ClinGen gnomAD
TCGA novel	421	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773678647 CA861719	422	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs761392187 CA861720	422	R>W		No	ClinGen ExAC TOPMed gnomAD
CA22665917 rs990904873	423	P>L		No	ClinGen Ensembl
CA340409943 rs1359144172	425	V>L		No	ClinGen TOPMed
rs1239065935 CA340409921	426	P>S		No	ClinGen gnomAD
CA340409892 rs1213402668	427	P>L		No	ClinGen TOPMed gnomAD
rs1285257877 CA340409856	430	K>E		No	ClinGen gnomAD
CA861716 rs139582452	430	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA861715 rs771307875	433	L>R		No	ClinGen ExAC gnomAD
rs1248364434 CA340409742	437	K>E		No	ClinGen TOPMed
rs1557575048 CA340409714	439	S>F		No	ClinGen Ensembl
rs772418834 CA861714	439	S>P		No	ClinGen ExAC TOPMed gnomAD
CA861712 rs772397728	440	T>A		No	ClinGen ExAC gnomAD
rs1421297602 CA340409705	441	P>S		No	ClinGen TOPMed gnomAD
rs748315192 CA861711	442	D>H		No	ClinGen ExAC gnomAD
CA340409685 rs1346197592	444	V>M		No	ClinGen TOPMed gnomAD
CA22665863 rs112803162	456	M>V		No	ClinGen Ensembl
CA340409581 COSM910798 rs1423835292	458	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs750176888 CA861704	459	M>I		No	ClinGen ExAC gnomAD
rs781204599 CA861703	461	G>R		No	ClinGen ExAC gnomAD
rs757135853 CA861702	462	I>L		No	ClinGen ExAC TOPMed gnomAD
rs751118664 CA861701	462	I>S		No	ClinGen ExAC TOPMed gnomAD
rs763488794 CA861700	464	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA861699 rs531070097	465	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA861695 rs773550804	469	Y>C		No	ClinGen ExAC gnomAD
CA861694 CA861693 rs547377162	470	G>R		No	ClinGen ExAC TOPMed gnomAD
rs180774404 CA861692	471	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA861691 rs145662692	472	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs145662692 CA340409406	472	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA340409408 rs1242479138	472	P>S		No	ClinGen gnomAD
rs780432280 CA861688	477	L>P		No	ClinGen ExAC gnomAD
rs1351156920 CA340409338	478	I>V		No	ClinGen gnomAD
CA340409322 rs1167677221	479	R>K		No	ClinGen gnomAD
rs770087117 CA861687	480	R>K		No	ClinGen ExAC gnomAD
CA340409294 rs780817009	481	G>E		No	ClinGen ExAC TOPMed gnomAD
rs780817009 CA861685	481	G>V		No	ClinGen ExAC TOPMed gnomAD
CA861682 rs777722453	487	S>L		No	ClinGen ExAC TOPMed gnomAD
CA22665682 rs762296132	489	S>A		No	ClinGen Ensembl
rs781422428 CA861668	490	D>G		No	ClinGen ExAC TOPMed gnomAD
rs770658717 CA861667	491	Q>K		No	ClinGen ExAC gnomAD
rs961205885 CA22665554	493	M>T		No	ClinGen TOPMed gnomAD
rs1209407324 CA340408822	494	T>I		No	ClinGen gnomAD
rs746751505 CA861666	495	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	495	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340408782 rs1229687045	498	N>D		No	ClinGen TOPMed
CA340408751 rs1235796882	500	S>P		No	ClinGen gnomAD
rs1390346580 CA340408723	502	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs747722166 CA861663	503	T>P		No	ClinGen ExAC gnomAD
CA861662 rs148333247	505	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA861661 rs148333247	505	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA861660 rs753456285	507	A>V		No	ClinGen ExAC gnomAD
CA861658 rs757570881	509	G>D		No	ClinGen ExAC gnomAD
CA861659 rs766015082	509	G>R		No	ClinGen ExAC TOPMed
CA340408649 rs766015082	509	G>S		No	ClinGen ExAC TOPMed
rs1007180217 CA22665512	510	K>E		No	ClinGen TOPMed gnomAD
rs1158610970 CA340408615	511	T>I		No	ClinGen TOPMed gnomAD
rs1158610970 CA340408619	511	T>K		No	ClinGen TOPMed gnomAD
CA340408605 rs1414345990	512	M>K		No	ClinGen gnomAD
CA861657 rs371740668	512	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1185885389 CA340408569	514	Q>K		No	ClinGen gnomAD
CA22665494 rs865777947	516	S>G		No	ClinGen Ensembl
TCGA novel	521	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340408353 rs1485074488	523	Q>R		No	ClinGen gnomAD
CA861654 rs775759231	524	N>S		No	ClinGen ExAC gnomAD
CA861653 rs765426871	526	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759616562 CA861652	526	R>H		No	ClinGen ExAC TOPMed gnomAD
CA340408241 rs1451726391	527	E>A		No	ClinGen TOPMed gnomAD
TCGA novel	528	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	530	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA861633 rs766575190	531	N>H		No	ClinGen ExAC gnomAD
rs773041461 CA861631	536	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA22663286 rs868754994	536	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1402969606 CA340407002	537	V>M		No	ClinGen gnomAD
rs1052798711 CA22663273	538	L>P		No	ClinGen Ensembl
CA22663268 CA861629 rs747898308	540	M>I		No	ClinGen ExAC TOPMed gnomAD
CA861628 rs376027518	541	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA861627 rs149157348	542	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748810834 CA861626	542	F>L		No	ClinGen ExAC TOPMed gnomAD
rs779614470 CA861625	543	F>S		No	ClinGen ExAC gnomAD
TCGA novel	547	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	549	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215774042 CA340405595	551	I>T		No	ClinGen TOPMed gnomAD
CA861608 rs754591838	552	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA22660601 rs754591838	552	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs775239207 CA861607	553	A>G		No	ClinGen ExAC gnomAD
rs1417019857 CA340405553	553	A>T		No	ClinGen TOPMed
rs775239207 CA22660590	553	A>V		No	ClinGen ExAC gnomAD
CA22660586 rs982897957	554	V>F		No	ClinGen Ensembl
TCGA novel	556	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1282151676 CA340405397	558	A>T		No	ClinGen gnomAD
CA861606 rs769374376	565	L>F		No	ClinGen ExAC gnomAD
rs1235332947 CA340405217	566	E>G		No	ClinGen TOPMed gnomAD
rs1442750989 CA340404741	570	H>R		No	ClinGen gnomAD
rs762612478 CA861584	576	F>L		No	ClinGen ExAC gnomAD
CA340404647 rs1289140721	577	T>I		No	ClinGen TOPMed gnomAD
CA861583 rs775500548	579	D>G		No	ClinGen ExAC gnomAD
CA340404598 rs1354131056	581	F>C		No	ClinGen TOPMed gnomAD
CA340404601 rs1354131056	581	F>S		No	ClinGen TOPMed gnomAD
TCGA novel	583	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140071660 CA861582	586	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487242245 CA340404533	587	T>S		No	ClinGen gnomAD
CA861580 rs187459137	589	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340404519 rs187459137	589	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340404501 rs985735319	591	I>L		No	ClinGen TOPMed gnomAD
CA22659084 rs985735319	591	I>V		No	ClinGen TOPMed gnomAD
rs142123604 CA861579	595	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	596	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA340404421 rs1473257110	597	T>A		No	ClinGen TOPMed gnomAD
CA340404420 rs1473257110	597	T>S		No	ClinGen TOPMed gnomAD
CA340404406 rs1181251964	599	Q>K		No	ClinGen TOPMed gnomAD
rs1413313440 CA340404392	600	E>K		No	ClinGen TOPMed
CA861556 rs770330848	602	V>I		No	ClinGen ExAC TOPMed gnomAD
rs971271043 CA22652549	603	D>A		No	ClinGen Ensembl
CA340402853 COSM191630 rs1207224755	603	D>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs370908994 CA861554	606	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs866357765 CA22652545	609	P>S		No	ClinGen Ensembl
CA22652530 rs959770902	610	H>R		No	ClinGen TOPMed
rs752886954 CA22652535	610	H>Y		No	ClinGen Ensembl
CA340402750 rs1191672421	611	A>D		No	ClinGen TOPMed
CA340402727 rs1436908688	613	S>I		No	ClinGen gnomAD
CA340402719 rs1419385982	614	K>E		No	ClinGen TOPMed
CA861551 rs778111779	616	P>A		No	ClinGen ExAC gnomAD
CA340402684 rs1351569869	617	R>Q		No	ClinGen TOPMed gnomAD
rs991404778 CA22652510	617	R>W		No	ClinGen TOPMed gnomAD
rs752576015 CA861549	620	G>R		No	ClinGen ExAC gnomAD
CA861548 rs537860765	623	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA340402621 rs1429000953	623	V>L		No	ClinGen gnomAD
rs754769846 CA861547	624	D>G		No	ClinGen ExAC TOPMed gnomAD
rs200700767 CA22652503	624	D>N		No	ClinGen TOPMed
rs1380450785 CA340402600	625	T>N		No	ClinGen TOPMed
CA340402605 rs1331832371	625	T>P		No	ClinGen gnomAD
rs753857188 CA861546	627	Y>*		No	ClinGen ExAC gnomAD
rs116087466 CA861545	629	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760276805 CA861544	632	F>S		No	ClinGen ExAC gnomAD
CA861543 rs772584790	633	A>T		No	ClinGen ExAC gnomAD
CA22652484 rs1037137633	635	R>G		No	ClinGen TOPMed
rs552272020 CA861542	635	R>T		No	ClinGen 1000Genomes ExAC gnomAD
CA340402529 rs1483662058	636	A>V		No	ClinGen gnomAD
CA340402518 rs1320094986	638	L>R		No	ClinGen TOPMed
CA340402499 rs1310088289	640	T>A		No	ClinGen gnomAD
CA22652475 rs577396104	641	A>S		No	ClinGen Ensembl
CA340402485 rs1219339303	641	A>V		No	ClinGen gnomAD
CA340402464 rs1305624782	643	Y>C		No	ClinGen gnomAD
CA861538 rs759826117	644	R>G		No	ClinGen ExAC TOPMed gnomAD
rs777133467 CA861537	644	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771410262 CA861536	647	T>S		No	ClinGen ExAC gnomAD
CA340402408 rs1485785099	648	T>I		No	ClinGen TOPMed
TCGA novel	650	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779858388 CA22652453	650	G>D		No	ClinGen Ensembl
CA340402369 rs1215071422	652	H>R		No	ClinGen TOPMed
rs759948741 CA861520	657	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA340401396 rs1183892520	659	S>F		No	ClinGen gnomAD
rs1462384353 COSM1320988 CA340401393	660	A>T	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs771465194 CA861518	660	A>V		No	ClinGen ExAC gnomAD
CA22650132 rs868742838	662	H>Q		No	ClinGen Ensembl
CA22650133 rs1029795542	662	H>Y		No	ClinGen gnomAD
rs1261947294 CA340401356	663	Q>K		No	ClinGen gnomAD
CA861516 rs374774558	664	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs371861925 CA861515	665	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA340401314 rs1458339351	666	L>V		No	ClinGen gnomAD
TCGA novel	667	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs534511439 CA861514	668	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs534511439 CA340401287	668	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA861512 rs756360674	672	F>L		No	ClinGen ExAC TOPMed gnomAD
CA340401236 rs1230730504	672	F>V		No	ClinGen TOPMed
TCGA novel	674	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q9BTX1

No regional properties for Q9BTX1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BTX1

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nuclear pore complex Nucleus membrane; Multi-pass membrane protein	Central core structure of the nuclear pore complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nuclear pore transmembrane ring	A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
protein-macromolecule adaptor activity	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
structural constituent of nuclear pore	The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

8 GO annotations of biological process

Name	Definition
homologous chromosome pairing at meiosis	The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear pore complex assembly	The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
nuclear pore localization	Any process in which nuclear pores are transported to, or maintained in, a specific location.
nuclear pore organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore.
nucleocytoplasmic transport	The directed movement of molecules between the nucleus and the cytoplasm.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8VCB1	Ndc1	Nucleoporin NDC1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MATAVSRPCA	GRSRDILWRV	LGWRIVASIV	WSVLFLPICT	TVFIIFSRID	LFHPIQWLSD
70	80	90	100	110	120
SFSDLYSSYV	IFYFLLLSVV	IIIISIFNVE	FYAVVPSIPC	SRLALIGKII	HPQQLMHSFI
130	140	150	160	170	180
HAAMGMVMAW	CAAVITQGQY	SFLVVPCTGT	NSFGSPAAQT	CLNEYHLFFL	LTGAFMGYSY
190	200	210	220	230	240
SLLYFVNNMN	YLPFPIIQQY	KFLRFRRSLL	LLVKHSCVES	LFLVRNFCIL	YYFLGYIPKA
250	260	270	280	290	300
WISTAMNLHI	DEQVHRPLDT	VSGLLNLSLL	YHVWLCGVFL	LTTWYVSWIL	FKIYATEAHV
310	320	330	340	350	360
FPVQPPFAEG	SDECLPKVLN	SNPPPIIKYL	ALQDLMLLSQ	YSPSRRQEVF	SLSQPGGHPH
370	380	390	400	410	420
NWTAISRECL	NLLNGMTQKL	ILYQEAAATN	GRVSSSYPVE	PKKLNSPEET	AFQTPKSSQM
430	440	450	460	470	480
PRPSVPPLVK	TSLFSSKLST	PDVVSPFGTP	FGSSVMNRMA	GIFDVNTCYG	SPQSPQLIRR
490	500	510	520	530	540
GPRLWTSASD	QQMTEFSNPS	PSTSISAEGK	TMRQPSVIYS	WIQNKREQIK	NFLSKRVLIM
550	560	570	580	590	600
YFFSKHPEAS	IQAVFSDAQM	HIWALEGLSH	LVAASFTEDR	FGVVQTTLPA	ILNTLLTLQE
610	620	630	640	650	660
AVDKYFKLPH	ASSKPPRISG	SLVDTSYKTL	RFAFRASLKT	AIYRITTTFG	EHLNAVQASA
670
EHQKRLQQFL	EFKE