AiPD: Autoinhibited Protein Database

Q9BRJ2

Gene name	MRPL45
Protein name	39S ribosomal protein L45, mitochondrial
Names	L45mt, MRP-L45, Mitochondrial large ribosomal subunit protein mL45
Species	Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-149 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

4-149 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

61 structures for Q9BRJ2

Entry ID	Method	Resolution	Chain	Position	Source
3J7Y	EM	340 A	d	1-306	PDB
3J9M	EM	350 A	d	1-306	PDB
5OOL	EM	306 A	d	1-306	PDB
5OOM	EM	303 A	d	1-306	PDB
6I9R	EM	390 A	d	1-306	PDB
6NU2	EM	390 A	d	117-287	PDB
6NU3	EM	440 A	d	1-306	PDB
6VLZ	EM	297 A	d	1-306	PDB
6VMI	EM	296 A	d	1-306	PDB
6ZM5	EM	289 A	d	1-306	PDB
6ZM6	EM	259 A	d	1-306	PDB
6ZS9	EM	400 A	d	1-306	PDB
6ZSA	EM	400 A	d	55-306	PDB
6ZSB	EM	450 A	d	55-306	PDB
6ZSC	EM	350 A	d	55-306	PDB
6ZSD	EM	370 A	d	55-306	PDB
6ZSE	EM	500 A	d	56-306	PDB
6ZSG	EM	400 A	d	55-306	PDB
7A5F	EM	440 A	d3	1-306	PDB
7A5G	EM	433 A	d3	1-306	PDB
7A5H	EM	330 A	d	1-306	PDB
7A5I	EM	370 A	d3	1-306	PDB
7A5J	EM	310 A	d	1-306	PDB
7A5K	EM	370 A	d3	1-306	PDB
7L08	EM	349 A	d	1-306	PDB
7L20	EM	315 A	d	1-306	PDB
7O9K	EM	310 A	d	1-306	PDB
7O9M	EM	250 A	d	1-302	PDB
7ODR	EM	290 A	d	1-306	PDB
7ODS	EM	310 A	d	1-306	PDB
7ODT	EM	310 A	d	1-306	PDB
7OF0	EM	220 A	d	1-306	PDB
7OF2	EM	270 A	d	1-306	PDB
7OF3	EM	270 A	d	1-306	PDB
7OF4	EM	270 A	d	1-306	PDB
7OF5	EM	290 A	d	1-306	PDB
7OF6	EM	260 A	d	1-306	PDB
7OF7	EM	250 A	d	1-306	PDB
7OG4	EM	380 A	d	1-306	PDB
7OI6	EM	570 A	d	1-306	PDB
7OI7	EM	350 A	d	1-306	PDB
7OI8	EM	350 A	d	1-306	PDB
7OI9	EM	330 A	d	1-306	PDB
7OIA	EM	320 A	d	1-306	PDB
7OIB	EM	330 A	d	1-306	PDB
7OIC	EM	310 A	d	1-306	PDB
7OID	EM	370 A	d	1-306	PDB
7OIE	EM	350 A	d	1-306	PDB
7PD3	EM	340 A	d	1-306	PDB
7PO4	EM	256 A	d	1-306	PDB
7QH6	EM	308 A	d	1-306	PDB
7QH7	EM	289 A	d	117-285	PDB
7QI4	EM	221 A	d	1-306	PDB
7QI5	EM	263 A	d	1-306	PDB
7QI6	EM	298 A	d	1-306	PDB
8ANY	EM	285 A	d	1-306	PDB
8OIR	EM	310 A	Bu	1-306	PDB
8OIT	EM	290 A	Bu	1-306	PDB
8PK0	EM	303 A	d	1-306	PDB
8QSJ	EM	300 A	d	1-306	PDB
AF-Q9BRJ2-F1	Predicted				AlphaFoldDB

244 variants for Q9BRJ2

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs751290816	2	A>V	No	ExAC gnomAD
rs761623144	3	A>V	No	ExAC gnomAD
rs750029992	4	P>R	No	ExAC TOPMed gnomAD
rs572037194	4	P>S	No	1000Genomes ExAC gnomAD
rs1418857198	5	I>M	No	gnomAD
rs779694164	5	I>T	No	ExAC gnomAD
rs1179413434	5	I>V	No	gnomAD
rs753461331	6	P>T	No	ExAC gnomAD
rs755507967	7	Q>K	No	ExAC TOPMed gnomAD
rs779609640	7	Q>P	No	ExAC gnomAD
rs540817995	8	G>A	No	1000Genomes ExAC gnomAD
rs540817995	8	G>E	No	1000Genomes ExAC gnomAD
rs1598968430	8	G>W	No	Ensembl
rs771211724	9	F>L	No	ExAC gnomAD
rs369403551	10	S>F	No	Ensembl
rs774307358	11	C>F	No	ExAC TOPMed gnomAD
rs759664237	11	C>G	No	ExAC gnomAD
rs759664237	11	C>R	No	ExAC gnomAD
rs774307358	11	C>S	No	ExAC TOPMed gnomAD
rs564266991	14	R>K	No	1000Genomes ExAC
rs1338482674	15	F>C	No	TOPMed
rs9890011	15	F>L	No	ExAC TOPMed gnomAD
rs9890011	15	F>V	No	ExAC TOPMed gnomAD
rs1268381454	16	L>S	No	TOPMed
rs766165413	17	G>D	No	ExAC TOPMed gnomAD
rs760395346	17	G>S	No	ExAC gnomAD
rs766165413	17	G>V	No	ExAC TOPMed gnomAD
rs753373604	18	W>*	No	ExAC TOPMed gnomAD
rs1376803621	18	W>G	No	Ensembl
rs764869599	19	W>C	No	ExAC gnomAD
rs754485911	19	W>G	No	ExAC gnomAD
rs11559007	20	F>S	No	1000Genomes ESP ExAC TOPMed gnomAD
rs1445638551	21	R>L	No	gnomAD
rs1183757774	22	Q>E	No	TOPMed gnomAD
rs764557956	23	P>A	No	ExAC gnomAD
rs1469464233	26	V>A	No	TOPMed
rs1177963085	26	V>L	No	TOPMed
rs1285744498	27	T>P	No	gnomAD
rs1249282911	28	Q>E	No	TOPMed
rs752085648	28	Q>P	No	ExAC gnomAD
rs1223261424	29	S>F	No	gnomAD
rs781545260	30	A>E	No	ExAC gnomAD
rs149900445	30	A>T	No	1000Genomes ESP ExAC TOPMed gnomAD
rs144913122	31	A>V	No	1000Genomes ESP ExAC TOPMed gnomAD
rs202175908	32	I>T	No	ESP ExAC TOPMed gnomAD
rs1567711645	32	I>V	No	Ensembl
rs780182001	34	P>S	No	ExAC TOPMed gnomAD
rs1222802483	40	R>C	No	TOPMed
rs1480745551	43	P>L	No	gnomAD
rs1198641582	44	P>L	No	TOPMed gnomAD
rs1198641582	44	P>R	No	TOPMed gnomAD
rs1286778830	46	Y>C	No	TOPMed
rs149031866	47	Q>L	No	ESP ExAC TOPMed gnomAD
rs149031866	47	Q>R	No	ESP ExAC TOPMed gnomAD
rs1312786178	48	P>L	No	TOPMed
rs143001775	54	K>N	No	ESP ExAC TOPMed gnomAD
rs775042643	61	R>Q	No	ExAC TOPMed gnomAD
rs550031536	61	R>W	No	ExAC TOPMed gnomAD
rs1404841321	64	G>R	No	gnomAD
rs1273606408	67	I>F	No	gnomAD
rs1375909963	68	P>S	No	gnomAD
rs1284515139	71	K>N	No	gnomAD
rs763692696	72	S>L	No	ExAC TOPMed gnomAD
rs200826398	73	D>G	No	1000Genomes ESP ExAC TOPMed gnomAD
rs767858823	74	R>C	No	ExAC gnomAD
rs370995176	74	R>H	No	1000Genomes ESP ExAC TOPMed gnomAD
rs370995176	74	R>P	No	1000Genomes ESP ExAC TOPMed gnomAD
rs754109055	77	H>R	No	ExAC gnomAD
rs1177626514	78	L>P	No	gnomAD
rs375901941	79	A>S	No	1000Genomes ESP ExAC TOPMed gnomAD
rs779136593	79	A>V	No	ExAC TOPMed gnomAD
rs746883882	80	C>R	No	ExAC TOPMed gnomAD
rs771049793	81	T>I	No	ExAC TOPMed gnomAD
rs757229128	82	A>D	No	ExAC gnomAD
rs1322076005	82	A>T	No	gnomAD
rs1281960415	83	G>C	No	TOPMed gnomAD
rs781227879	88	Y>C	No	ExAC TOPMed gnomAD
rs796923226	92	E>D	No	Ensembl
rs745850059	94	D>E	No	ExAC gnomAD
rs1329673003	94	D>N	No	TOPMed
rs1315764772	95	A>V	No	gnomAD
rs769411482	96	R>C	No	ExAC TOPMed gnomAD
rs201673456	96	R>H	No	1000Genomes ExAC TOPMed gnomAD
rs201673456	96	R>L	No	1000Genomes ExAC TOPMed gnomAD
rs768425986	97	I>M	No	ExAC TOPMed gnomAD
rs748882360	97	I>V	No	ExAC gnomAD
rs1166854831	99	S>P	No	TOPMed
rs1475790531	104	G>R	No	gnomAD
rs1247558692	104	G>V	No	TOPMed gnomAD
rs146880577	106	I>M	No	1000Genomes ESP ExAC TOPMed gnomAD
rs565835633	107	E>K	No	1000Genomes ExAC TOPMed gnomAD
rs1182439753	108	R>K	No	TOPMed
rs771589881	110	E>V	No	ExAC gnomAD
rs773667082	111	R>*	No	ExAC gnomAD
rs761246807	111	R>Q	No	ExAC TOPMed gnomAD
rs145103209	112	M>V	No	1000Genomes ESP ExAC TOPMed gnomAD
rs1212464094	114	K>T	No	TOPMed
rs1277516786	115	T>S	No	TOPMed
rs759672117	116	M>T	No	ExAC gnomAD
rs777110378	116	M>V	No	ExAC TOPMed gnomAD
rs765595706	117	A>T	No	ExAC TOPMed gnomAD
rs750271913	120	V>M	No	ExAC gnomAD
rs756136684	121	S>*	No	ExAC gnomAD
rs756136684	121	S>L	No	ExAC gnomAD
rs766391949	123	R>Q	No	ExAC gnomAD
rs755977222	123	R>W	No	ExAC TOPMed gnomAD
rs140700150	124	R>G	No	ESP TOPMed gnomAD
rs753737673	124	R>K	No	ExAC gnomAD
rs1248695910	124	R>S	No	TOPMed
rs754724111	125	I>M	No	ExAC gnomAD
rs778681166	126	K>R	No	ExAC gnomAD
rs1208374259	127	D>G	No	TOPMed
rs1038042577	132	F>C	No	TOPMed
rs1221960454	134	I>M	No	TOPMed
rs549458356	136	D>N	No	1000Genomes ExAC TOPMed gnomAD
rs549458356	136	D>Y	No	1000Genomes ExAC TOPMed gnomAD
rs1246894002	137	F>I	No	gnomAD
rs1265362528	138	P>T	No	gnomAD
rs1230481876	141	A>V	No	TOPMed
rs777142127	143	D>N	No	ExAC gnomAD
rs535030813	145	F>V	No	1000Genomes ExAC gnomAD
rs200187779	146	I>T	No	ExAC TOPMed gnomAD
rs1378170271	147	E>K	No	gnomAD
rs1380172570	148	A>V	No	TOPMed
rs1203394103	149	H>P	No	gnomAD
rs1293738206	151	C>*	No	TOPMed
rs746382914	151	C>G	No	ExAC TOPMed gnomAD
rs770226464	151	C>S	No	ExAC gnomAD
rs776057704	153	N>S	No	ExAC gnomAD
rs138400231	154	N>D	No	1000Genomes ESP ExAC TOPMed gnomAD
rs746362550	154	N>K	No	ExAC TOPMed gnomAD
rs987776697	156	D>A	No	TOPMed gnomAD
rs1217144367	158	D>V	No	gnomAD
rs749716574	159	R>*	No	ExAC gnomAD
rs138863014	159	R>L	No	1000Genomes ESP ExAC TOPMed gnomAD
rs138863014	159	R>Q	No	1000Genomes ESP ExAC TOPMed gnomAD
rs772136728	161	H>Y	No	ExAC TOPMed gnomAD
rs1397637670	162	T>I	No	gnomAD
rs1187384372	165	T>I	No	Ensembl
rs1187826082	168	C>S	No	gnomAD
rs762811241	171	D>N	No	ExAC TOPMed gnomAD
rs377038278	178	Y>S	No	ESP ExAC gnomAD
rs1567719115	180	T>A	No	Ensembl
rs866134620	180	T>I	No	Ensembl
rs767325233	181	V>I	No	ExAC TOPMed gnomAD
rs767325233	181	V>L	No	ExAC TOPMed gnomAD
rs765996581	182	R>C	No	ExAC TOPMed gnomAD
rs754342790	182	R>H	No	ExAC gnomAD
rs1484482014	183	W>G	No	gnomAD
rs1241811642	185	F>S	No	gnomAD
rs1214910361	185	F>V	No	TOPMed
rs1352254216	189	L>S	No	TOPMed gnomAD
rs779333433	191	P>S	No	ExAC gnomAD
rs758625208	192	S>A	No	ExAC gnomAD
rs1246034854	192	S>F	No	TOPMed
rs529303050	198	R>C	No	1000Genomes ExAC TOPMed gnomAD
rs770940030	198	R>H	No	ExAC gnomAD
rs1244323302	199	C>Y	No	TOPMed
rs1437893452	202	M>R	No	TOPMed gnomAD
rs1437893452	202	M>T	No	TOPMed gnomAD
rs549274705	203	M>I	No	1000Genomes ExAC gnomAD
rs1043560556	205	Q>E	No	TOPMed
rs768514292	207	N>Y	No	ExAC gnomAD
rs1356586760	208	V>L	No	TOPMed gnomAD
rs1356586760	208	V>M	No	TOPMed gnomAD
rs999392757	210	G>A	No	gnomAD
rs767448037	210	G>S	No	ExAC TOPMed gnomAD
rs149351371	212	I>L	No	ESP ExAC TOPMed gnomAD
rs1384918108	213	T>I	No	TOPMed
rs765978217	214	V>I	No	ExAC gnomAD
rs765978217	214	V>L	No	ExAC gnomAD
rs201256877	215	R>C	No	1000Genomes ExAC TOPMed gnomAD
rs765714356	215	R>H	No	ExAC TOPMed gnomAD
rs758651947	216	M>T	No	ExAC gnomAD
rs989923588	218	T>A	No	TOPMed gnomAD
rs747219347	218	T>I	No	ExAC gnomAD
rs781217215	219	R>Q	No	ExAC gnomAD
rs147446793	219	R>W	No	1000Genomes ESP ExAC TOPMed gnomAD
rs745981973	220	Q>H	No	ExAC gnomAD
rs1277509962	222	L>P	No	gnomAD
rs1156396000	224	I>T	No	TOPMed
rs1338070995	226	D>V	No	gnomAD
rs138951204	227	R>P	No	ESP ExAC TOPMed gnomAD
rs138951204	227	R>Q	No	ESP ExAC TOPMed gnomAD
rs772206916	227	R>W	No	ExAC TOPMed gnomAD
rs1567719675	229	G>D	No	Ensembl
rs770873976	230	R>L	No	ExAC gnomAD
rs770873976	230	R>Q	No	ExAC gnomAD
rs746853026	230	R>W	No	ExAC TOPMed gnomAD
rs1288188003	231	L>W	No	gnomAD
rs1488663916	232	M>I	No	gnomAD
rs759231951	237	D>E	No	ExAC gnomAD
rs769129456	238	V>I	No	ExAC gnomAD
rs1377814336	242	V>I	No	gnomAD
rs763419495	243	L>M	No	ExAC gnomAD
rs200432117	244	E>*	No	1000Genomes ExAC gnomAD
rs1419786763	246	V>A	No	gnomAD
rs752081666	246	V>I	No	ExAC gnomAD
rs767927015	249	E>K	No	ExAC TOPMed gnomAD
rs767927015	249	E>Q	No	ExAC TOPMed gnomAD
rs1285600030	249	E>V	No	TOPMed
rs1388276569	250	K>R	No	gnomAD
rs756420599	251	Q>*	No	ExAC gnomAD
rs1231259516	252	L>S	No	gnomAD
rs200662041	254	N>D	No	1000Genomes ExAC TOPMed gnomAD
rs1597658199	255	P>L	No	Ensembl
rs972920994	255	P>T	No	Ensembl
rs367983742	256	Y>C	No	ESP ExAC TOPMed gnomAD
rs1210993839	260	R>K	No	gnomAD
rs879152708	261	M>L	No	Ensembl
rs1597658218	261	M>R	No	Ensembl
rs746975943	262	H>R	No	ExAC gnomAD
rs1191293963	263	T>I	No	gnomAD
rs773319858	264	K>N	No	Ensembl
rs199777667	264	K>R	No	1000Genomes
rs147413623	266	V>I	No	1000Genomes ESP ExAC TOPMed gnomAD
rs1338694299	267	P>A	No	TOPMed
rs1361590581	268	P>L	No	TOPMed gnomAD
rs1361590581	268	P>R	No	TOPMed gnomAD
rs769525885	269	W>R	No	ExAC gnomAD
rs774838592	270	A>T	No	ExAC TOPMed gnomAD
rs1251136872	271	P>S	No	gnomAD
rs748746743	272	P>A	No	ExAC TOPMed gnomAD
rs201020968	272	P>R	No	ExAC TOPMed gnomAD
rs748746743	272	P>S	No	ExAC TOPMed gnomAD
rs748746743	272	P>T	No	ExAC TOPMed gnomAD
rs767757409	274	Q>P	No	ExAC TOPMed
rs78974899	275	P>L	No	1000Genomes ExAC TOPMed gnomAD
rs375375679	278	K>E	No	ESP ExAC TOPMed gnomAD
rs771506994	279	T>M	No	ExAC gnomAD
rs747476271	281	M>I	No	ExAC gnomAD
rs1184615929	283	P>L	No	gnomAD
rs200400481	284	G>S	No	ESP ExAC TOPMed gnomAD
rs1433948262	286	Q>P	No	gnomAD
rs1175638887	287	L>P	No	TOPMed gnomAD
rs148452807	288	K>R	No	ESP TOPMed gnomAD
rs142587309	292	E>D	No	ESP ExAC TOPMed gnomAD
rs1429020715	294	E>*	No	gnomAD
rs34749623 VAR_061810	298	G>V	No	UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs370336712	300	A>T	No	ESP ExAC TOPMed gnomAD
rs1284385551	303	P>A	No	TOPMed
rs764084920	306	A>V	No	ExAC TOPMed gnomAD
rs200734868	307	A>C	No	1000Genomes ExAC TOPMed gnomAD
rs200734868	307	A>W	No	1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q9BRJ2

1 regional properties for Q9BRJ2

Type	Name	Position	InterPro Accession
domain	Tim44-like domain	118 - 266	IPR007379

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAAPIPQGFS	CLSRFLGWWF	RQPVLVTQSA	AIVPVRTKKR	FTPPIYQPKF	KTEKEFMQHA
70	80	90	100	110	120
RKAGLVIPPE	KSDRSIHLAC	TAGIFDAYVP	PEGDARISSL	SKEGLIERTE	RMKKTMASQV
130	140	150	160	170	180
SIRRIKDYDA	NFKIKDFPEK	AKDIFIEAHL	CLNNSDHDRL	HTLVTEHCFP	DMTWDIKYKT
190	200	210	220	230	240
VRWSFVESLE	PSHVVQVRCS	SMMNQGNVYG	QITVRMHTRQ	TLAIYDRFGR	LMYGQEDVPK
250	260	270	280	290	300
DVLEYVVFEK	QLTNPYGSWR	MHTKIVPPWA	PPKQPILKTV	MIPGPQLKPE	EEYEEAQGEA

QKPQLA