AiPD: Autoinhibited Protein Database

Q9BQ67

Gene name	GRWD1 (GRWD, KIAA1942, WDR28)
Protein name	Glutamate-rich WD repeat-containing protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83743
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-154 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

83-154 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BQ67

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BQ67-F1	Predicted				AlphaFoldDB

453 variants for Q9BQ67

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs147327994 RCV000149314 COSM1179635 CA174767	198	R>Q	Malignant tumor of prostate prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9550891 rs767003669	2	A>V		No	ClinGen ExAC TOPMed
CA406681100 rs943455639	3	A>G		No	ClinGen gnomAD
CA9550892 rs752396659	3	A>P		No	ClinGen ExAC TOPMed gnomAD
CA406681091 rs752396659	3	A>T		No	ClinGen ExAC TOPMed gnomAD
CA309301417 rs943455639	3	A>V		No	ClinGen gnomAD
rs760213954 CA9550893	4	R>C		No	ClinGen ExAC gnomAD
CA9550894 rs763762231	4	R>H		No	ClinGen ExAC gnomAD
CA406681116 rs1195118835	5	K>E		No	ClinGen gnomAD
rs1474315735 CA406681151	7	R>P		No	ClinGen TOPMed gnomAD
rs1474315735 CA406681149	7	R>Q		No	ClinGen TOPMed gnomAD
CA406681145 rs757018412	7	R>W		No	ClinGen ExAC TOPMed gnomAD
rs374579517 CA9550898	8	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs547531552 CA9550901	9	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs547531552 CA9550902	9	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406681183 rs1490501860	10	T>M		No	ClinGen TOPMed
CA406681196 rs1415849526	11	C>Y		No	ClinGen gnomAD
CA406681215 rs771325293 CA9550906	12	E>D		No	ClinGen ExAC TOPMed gnomAD
CA406681211 rs1312635702	12	E>G		No	ClinGen gnomAD
CA406681223 rs1231009036	13	T>N		No	ClinGen gnomAD
rs1226033214 CA406681234	14	G>E		No	ClinGen gnomAD
CA406681230 rs1307519290	14	G>R		No	ClinGen gnomAD
CA9550908 rs760015830	15	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1251374362 CA406681266	16	P>H		No	ClinGen TOPMed
rs1256458718 CA406681261	16	P>S		No	ClinGen gnomAD
CA406681258 rs1256458718	16	P>T		No	ClinGen gnomAD
rs1188454248 CA406681290	17	M>I		No	ClinGen gnomAD
rs1484831450 CA406681284	17	M>T		No	ClinGen gnomAD
CA9550909 rs144932185	19	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA406681338 rs887047041	19	A>P		No	ClinGen TOPMed gnomAD
rs887047041 CA309301485	19	A>T		No	ClinGen TOPMed gnomAD
rs1168415121 CA406681350	20	E>K		No	ClinGen gnomAD
CA406681370 rs1601001067	21	S>A		No	ClinGen Ensembl
rs775013075 CA9550910	21	S>F		No	ClinGen ExAC gnomAD
rs1435817685 CA406681391	22	G>D		No	ClinGen gnomAD
CA406681382 rs1225694085	22	G>S		No	ClinGen TOPMed
rs776279416 CA9550913	23	D>G		No	ClinGen ExAC gnomAD
CA9550912 rs763665732	23	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1385582015 CA406681423	24	T>A		No	ClinGen TOPMed
rs1398814153 CA406681442	25	S>N		No	ClinGen TOPMed
rs1005600134 CA309301507	26	S>F		No	ClinGen gnomAD
rs1340842211 CA406681470	26	S>P		No	ClinGen gnomAD
rs761578462 CA9550914	27	E>K		No	ClinGen ExAC gnomAD
CA9550917 rs758376977	28	G>A		No	ClinGen ExAC TOPMed gnomAD
CA406681522 rs758376977	28	G>D		No	ClinGen ExAC TOPMed gnomAD
rs750432167 CA9550916	28	G>S		No	ClinGen ExAC gnomAD
rs766374937 CA9550918	29	P>L		No	ClinGen ExAC TOPMed gnomAD
rs766374937 CA406681539	29	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA406681559 rs1421702000	30	A>V		No	ClinGen TOPMed
rs1345526986 CA406681586	32	V>L		No	ClinGen TOPMed gnomAD
CA9550919 rs752842457	33	Y>C		No	ClinGen ExAC gnomAD
rs1242978952 CA406681604	33	Y>H		No	ClinGen gnomAD
rs752842457 CA309301524	33	Y>S		No	ClinGen ExAC gnomAD
rs1439455288 CA406681657	36	G>A		No	ClinGen TOPMed
CA309301538 rs78848583	37	R>G		No	ClinGen gnomAD
rs749514627 CA9550922	37	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA406681664 rs78848583	37	R>W		No	ClinGen gnomAD
TCGA novel	38	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402850141 CA406681682	38	G>V		No	ClinGen gnomAD
rs1345479416 CA406681704	39	P>L		No	ClinGen TOPMed gnomAD
rs1317992498 CA406681708	40	P>A		No	ClinGen gnomAD
CA406681724 rs1372478293	40	P>L		No	ClinGen gnomAD
rs558393336 CA309301545	42	R>H		No	ClinGen 1000Genomes gnomAD
rs1225307953 CA406681764	43	E>*		No	ClinGen TOPMed gnomAD
CA406681757 rs1225307953	43	E>K		No	ClinGen TOPMed gnomAD
rs779219427 CA9550924	44	G>E		No	ClinGen ExAC TOPMed gnomAD
CA9550923 rs757613737	44	G>R		No	ClinGen ExAC gnomAD
rs772590614 CA406681858	48	V>I		No	ClinGen ExAC TOPMed gnomAD
rs772590614 CA9550926	48	V>L		No	ClinGen ExAC TOPMed gnomAD
COSM1395022 rs1231757801 CA406681893	49	M>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA406681947 rs1199624471	51	E>K		No	ClinGen gnomAD
rs775917486 CA9550927	53	A>G		No	ClinGen ExAC gnomAD
rs1469004949 CA406681999	53	A>T		No	ClinGen gnomAD
CA406682030 rs1251754873	54	Y>F		No	ClinGen gnomAD
rs1471435655 CA406682069	56	L>F		No	ClinGen gnomAD
TCGA novel	57	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9550928 rs746505181	57	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA406682110 rs1012431716	58	H>N		No	ClinGen TOPMed gnomAD
rs768207196 CA9550929	58	H>R		No	ClinGen ExAC
rs1012431716 CA309301594	58	H>Y		No	ClinGen TOPMed gnomAD
CA406682131 rs1418170773	59	R>*		No	ClinGen TOPMed gnomAD
CA406682128 rs1418170773	59	R>G		No	ClinGen TOPMed gnomAD
CA406682296 rs1258573036	63	G>A		No	ClinGen gnomAD
CA406682195 rs1156562513	63	G>S		No	ClinGen TOPMed gnomAD
rs904836271 CA309301787	65	P>L		No	ClinGen Ensembl
rs1186344725 CA406682324	65	P>T		No	ClinGen TOPMed gnomAD
rs753973554 CA9550958	70	D>N		No	ClinGen ExAC gnomAD
CA9550959 rs761824697	71	I>L		No	ClinGen ExAC TOPMed gnomAD
CA9550960 rs761824697	71	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1398129245 CA406682463	73	R>Q		No	ClinGen TOPMed
rs758818281 CA9550962	73	R>W		No	ClinGen ExAC TOPMed gnomAD
rs138505126 CA9550964	75	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM304919 rs780443467 CA9550963	75	H>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1281517559 CA406682512	77	G>R		No	ClinGen gnomAD
CA9550968 rs747701574	77	G>V		No	ClinGen ExAC gnomAD
TCGA novel	78	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9550970 rs777629154	79	N>D		No	ClinGen ExAC gnomAD
rs1448361154 CA406682550	79	N>S		No	ClinGen gnomAD
rs748929813 CA9550971	80	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1193297764 CA406682560	80	R>W		No	ClinGen TOPMed gnomAD
rs770890791 CA406682579	82	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9550972 rs770890791	82	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA406682606 rs1433937751	84	P>L		No	ClinGen gnomAD
rs1056118500 CA309301930	84	P>S		No	ClinGen TOPMed gnomAD
CA406682613 rs1400527369	85	L>F		No	ClinGen gnomAD
rs1170580274 CA406682627	86	T>R		No	ClinGen gnomAD
rs1002664727 CA309301933	87	L>V		No	ClinGen TOPMed
CA309301938 rs1035850861	88	Y>D		No	ClinGen TOPMed
CA406682661 rs1317757068	89	L>*		No	ClinGen gnomAD
TCGA novel rs759203855 CA9550975 CA9550974	89	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
CA406682658 rs1401430711	89	L>V		No	ClinGen gnomAD
CA406682680 rs1443171204	90	C>W		No	ClinGen gnomAD
rs775223033 CA9550976	92	G>R		No	ClinGen ExAC gnomAD
rs1370909333 CA406682713	93	T>I		No	ClinGen gnomAD
CA406682715 rs1231609087	94	Q>K		No	ClinGen gnomAD
CA406682730 rs1569077390	95	A>T		No	ClinGen Ensembl
rs961077962 CA309301944	97	S>N		No	ClinGen TOPMed
rs140240394 CA9550977	97	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA406682773 rs1352401371	98	A>V		No	ClinGen gnomAD
rs1205314817 CA406682816	101	N>S		No	ClinGen gnomAD
rs1205314817 CA406682814	101	N>T		No	ClinGen gnomAD
rs1280814465 CA406682880	103	L>P		No	ClinGen TOPMed
rs745680554 CA9550991	104	M>I		No	ClinGen ExAC TOPMed gnomAD
rs778372921 CA9550990	104	M>V		No	ClinGen ExAC gnomAD
rs1252547854 CA406682910	105	M>I		No	ClinGen gnomAD
rs1438227348 CA406682929	107	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs973980013 CA309302061	114	T>I		No	ClinGen gnomAD
CA309302077 rs192256530	115	K>E		No	ClinGen 1000Genomes
CA9550992 rs771758365	116	P>L		No	ClinGen ExAC gnomAD
TCGA novel	117	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769899973 CA9550995	118	P>L		No	ClinGen ExAC gnomAD
rs746925561 CA406683073	118	P>S		No	ClinGen ExAC gnomAD
CA9550994 rs746925561	118	P>T		No	ClinGen ExAC gnomAD
CA406683112 rs773308912	121	G>C		No	ClinGen ExAC TOPMed gnomAD
CA9550997 rs773308912	121	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	122	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1569077504 CA406683149	123	D>E		No	ClinGen Ensembl
rs751837560 CA9550998	124	E>*		No	ClinGen ExAC gnomAD
rs1601001763 CA406683172	124	E>D		No	ClinGen Ensembl
rs1306497669 CA406683156	124	E>K		No	ClinGen TOPMed gnomAD
rs1569077519 COSM998963 CA406683185	125	E>D	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1433142926 CA406683194	126	E>K		No	ClinGen TOPMed
rs137971040 CA9551005	128	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA406683226 rs1601001786	128	E>K		No	ClinGen Ensembl
CA406683250 rs1237632415	129	E>D		No	ClinGen TOPMed
rs774435008 CA9551006	130	D>V		No	ClinGen ExAC TOPMed gnomAD
rs760008172 CA309302112	131	E>*		No	ClinGen ExAC gnomAD
rs760008172 CA9551008	131	E>K		No	ClinGen ExAC gnomAD
CA406683958 rs1209111210	133	D>E		No	ClinGen TOPMed
rs373794519 CA309302124	133	D>H		No	ClinGen ESP TOPMed
rs373794519 CA309302118	133	D>N		No	ClinGen ESP TOPMed
CA406683966 rs1175977335	134	E>K		No	ClinGen TOPMed gnomAD
rs1339980137 CA406683985	135	E>K		No	ClinGen gnomAD
rs1204199408 CA406684016	136	E>G		No	ClinGen gnomAD
rs1006520417 CA309302164	137	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9551010 rs200480479	137	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406684056 rs1188863566	139	P>T		No	ClinGen gnomAD
CA406684119 rs1374154461	143	L>M		No	ClinGen gnomAD
rs745493814 CA9551016	145	M>T		No	ClinGen ExAC gnomAD
rs371175718 CA9551015 COSM1612521	145	M>V	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA406684173 rs1377987172	146	V>G		No	ClinGen gnomAD
CA9551017 rs149492901	146	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs779791745 CA9551018	147	P>S		No	ClinGen ExAC gnomAD
rs768601092 CA406684207	148	H>Q		No	ClinGen ExAC gnomAD
CA9551019 rs150286220	148	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776488725 CA9551021	149	Y>C		No	ClinGen ExAC gnomAD
CA309302199 rs956803083	149	Y>N		No	ClinGen TOPMed gnomAD
rs776488725 CA406684216	149	Y>S		No	ClinGen ExAC gnomAD
CA406684232 rs1272237017	150	G>D		No	ClinGen gnomAD
CA9551023 rs375069485	152	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9551025 rs752123165	154	R>*		No	ClinGen ExAC TOPMed gnomAD
CA406684287 rs752123165	154	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1188363336 CA406684307	155	V>A		No	ClinGen gnomAD
rs1187275879 CA406684316	156	R>P		No	ClinGen TOPMed gnomAD
rs1187275879 CA406684314	156	R>Q		No	ClinGen TOPMed gnomAD
rs759649388 CA9551026	156	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406684929 rs1475935896	157	V>E		No	ClinGen TOPMed
CA9551044 rs778894183	158	S>A		No	ClinGen ExAC gnomAD
CA9551045 rs745913359	159	W>*		No	ClinGen ExAC gnomAD
rs1456314256 CA406684968	161	G>D		No	ClinGen gnomAD
CA406685007 rs1437057108	164	P>H		No	ClinGen gnomAD
rs200213949 CA9551049	168	V>G		No	ClinGen ExAC gnomAD
CA9551048 CA406685059 rs148152481	168	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406685057 rs148152481	168	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9551050 rs777326596	169	W>G		No	ClinGen ExAC TOPMed gnomAD
CA9551051 rs777326596	169	W>R		No	ClinGen ExAC TOPMed gnomAD
CA406685104 rs1236111427	170	S>L		No	ClinGen TOPMed
CA309305007 rs944223880	172	K>N		No	ClinGen Ensembl
CA406685188 rs1569078809	175	V>M		No	ClinGen Ensembl
rs1289290508 CA406685198	176	E>K		No	ClinGen gnomAD
rs765734169 CA9551052	177	V>G		No	ClinGen ExAC gnomAD
rs1226668033 CA406685242	178	F>L		No	ClinGen gnomAD
rs749920633 CA406685250	179	A>E		No	ClinGen ExAC TOPMed gnomAD
CA9551053 rs749920633	179	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1268121011 CA406685261	180	L>R		No	ClinGen TOPMed
CA309305035 rs766021879	181	R>G		No	ClinGen ExAC TOPMed gnomAD
rs199574524 CA9551057	181	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199574524 CA9551056	181	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766021879 CA9551055	181	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM1209090 CA9551059 rs752502004	182	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA9551058 rs201501296	182	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA406685345 rs1601004211	186	V>G		No	ClinGen Ensembl
COSM1209089 rs777708503 CA9551061	186	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA406685361 rs1419326653	187	V>A		No	ClinGen gnomAD
CA406685363 rs1419326653	187	V>G		No	ClinGen gnomAD
CA406685401 rs1569078835	189	E>D		No	ClinGen Ensembl
rs1405423543 CA406685432	191	Q>L		No	ClinGen gnomAD
CA9551062 rs745939644	192	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406685464 rs1444183327	193	L>R		No	ClinGen gnomAD
CA9551066 rs769181197	194	A>T		No	ClinGen ExAC gnomAD
CA9551067 rs144047399	195	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs568112921 CA9551069	196	F>S		No	ClinGen ExAC gnomAD
rs147327994 CA406685535	198	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9551071 rs201701983	198	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9551072 rs751255091	199	D>G		No	ClinGen ExAC gnomAD
rs1251494970 CA406685541	199	D>H		No	ClinGen gnomAD
rs1247729053 CA406685558	200	E>A		No	ClinGen TOPMed
CA406685571 rs1601004276	201	Q>E		No	ClinGen Ensembl
COSM1734864 rs370720690 CA9551073	202	A>T	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA9551074 rs767112071	204	M>I		No	ClinGen ExAC
rs1259135513 CA406685647	206	P>A		No	ClinGen gnomAD
rs140674923 CA309305126	207	I>L		No	ClinGen ESP
rs752450363 CA406685682	208	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1035987213 CA309305133	209	S>F		No	ClinGen Ensembl
TCGA novel	209	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs891739403 CA309305171	211	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9551077 rs777640423	211	A>V		No	ClinGen ExAC gnomAD
CA406685737 rs1369668422	212	G>A		No	ClinGen gnomAD
rs1322599161 CA406685729	212	G>R		No	ClinGen TOPMed gnomAD
CA406685761 rs1315062434	214	M>T		No	ClinGen gnomAD
rs753803007 CA9551078	214	M>V		No	ClinGen ExAC gnomAD
rs1341294712 CA406685770	215	G>S		No	ClinGen gnomAD
CA406685806 rs1277110044	217	G>D		No	ClinGen TOPMed
rs1282446606 CA406685800	217	G>S		No	ClinGen gnomAD
rs911606479 CA309305214	219	A>G		No	ClinGen TOPMed
CA406685822 rs1229340560	219	A>P		No	ClinGen TOPMed
CA9551082 rs755272077	221	D>A		No	ClinGen ExAC gnomAD
rs1601004361 CA406685845	221	D>E		No	ClinGen Ensembl
CA9551081 rs747045365	221	D>N		No	ClinGen ExAC gnomAD
rs1263783733 CA406685854	222	W>S		No	ClinGen gnomAD
CA406685866 rs1569078938	223	S>P		No	ClinGen Ensembl
CA406685872 rs1340527618	223	S>Y		No	ClinGen gnomAD
rs1455989802 CA406685887	224	P>L		No	ClinGen TOPMed
rs147465341 CA406685889	225	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770573431	225	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs770573431	225	R>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs748463030 CA9551085	225	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9551084 rs147465341	225	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9551087 rs139299867	226	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1569078977 CA406685921	228	G>S		No	ClinGen Ensembl
rs200765474 CA9551115	229	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs150020838 CA9551116	229	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs150020838 CA9551117	229	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs756383763 CA9551120	233	G>A		No	ClinGen ExAC gnomAD
CA406686033 rs145815703	233	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9551119 rs145815703	233	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406686048 rs1228489626	234	D>G		No	ClinGen gnomAD
CA9551121 rs777804069	235	C>R		No	ClinGen ExAC TOPMed gnomAD
CA9551122 rs754210394	237	K>Q		No	ClinGen ExAC gnomAD
rs779454124 CA9551124	243	T>I		No	ClinGen ExAC gnomAD
rs746353536 CA9551125	244	P>S		No	ClinGen ExAC gnomAD
CA9551126 rs539481541	245	T>M		No	ClinGen ExAC TOPMed gnomAD
rs564945522 CA9551130	246	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA406686231 rs1569079124	247	G>D		No	ClinGen Ensembl
CA9551132 rs769694855	247	G>S		No	ClinGen ExAC gnomAD
rs201666798 CA9551134	248	G>S		No	ClinGen ExAC TOPMed gnomAD
CA406686260 rs1424571186	250	W>R		No	ClinGen TOPMed
rs766182030 CA9551136	251	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs760608266 CA9551137	252	V>M		No	ClinGen ExAC TOPMed gnomAD
CA9551138 rs544363028	253	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1472225882 CA406686323	254	Q>*		No	ClinGen gnomAD
rs1207970981 CA406686340	255	R>Q		No	ClinGen TOPMed
rs754046830 CA9551139	255	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406686357 rs1326505023	256	P>R		No	ClinGen gnomAD
rs757669835 CA309305682	257	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1285411761 CA406686360	257	F>L		No	ClinGen TOPMed
CA406686361 rs1245098362	257	F>Y		No	ClinGen TOPMed
CA9551142 rs756088504	258	V>A		No	ClinGen ExAC gnomAD
rs779219307 CA9551141	258	V>M		No	ClinGen ExAC gnomAD
rs1451006188 CA406686369	259	G>S		No	ClinGen TOPMed
CA9551143 rs758965827	260	H>Q		No	ClinGen ExAC gnomAD
rs780367395 CA9551144	261	T>I		No	ClinGen ExAC TOPMed gnomAD
rs746532886 CA9551145	262	R>C		No	ClinGen ExAC TOPMed gnomAD
rs768042455 CA9551146	262	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781045719 CA9551147	265	E>D		No	ClinGen ExAC TOPMed gnomAD
CA406686458 rs1368592385	266	D>N		No	ClinGen TOPMed gnomAD
rs1188322606 CA406686482	267	L>R		No	ClinGen gnomAD
CA406686499 rs1458454048	268	Q>H		No	ClinGen TOPMed
CA406686484 rs1368416670	268	Q>K		No	ClinGen gnomAD
CA406686515 rs1368153810	269	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9551148 rs747778309	271	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1456782965 CA406686535	271	P>S		No	ClinGen gnomAD
rs1358367482 CA406686594	275	T>A		No	ClinGen gnomAD
CA9551150 rs773166425	275	T>M		No	ClinGen ExAC gnomAD
rs761822700 CA9551177	278	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1376713664 CA406686724	281	S>L		No	ClinGen gnomAD
rs1389298760 CA406686731	283	D>N		No	ClinGen gnomAD
rs763429005 CA406686742	284	A>D		No	ClinGen ExAC gnomAD
rs773302363 CA9551179	284	A>T		No	ClinGen ExAC gnomAD
rs763429005 CA9551180	284	A>V		No	ClinGen ExAC gnomAD
CA406686747 rs1440213856	285	S>C		No	ClinGen TOPMed
COSM1190102 CA9551181 rs766626456	286	I>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs149086809 CA9551182	287	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149086809 CA406686755	287	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9551183 rs755571291	287	R>H		No	ClinGen ExAC gnomAD
CA9551184 rs755571291	287	R>P		No	ClinGen ExAC gnomAD
rs752263846 CA9551185	288	I>L		No	ClinGen ExAC TOPMed gnomAD
CA9551186 rs755684797	288	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1329102216 CA406686775	290	D>A		No	ClinGen gnomAD
rs1248930135 CA406686782	291	I>F		No	ClinGen gnomAD
rs143441649 CA9551188	291	I>M		No	ClinGen ESP ExAC gnomAD
rs367969982 CA9551189	292	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1037527529 CA309306113	292	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1160790405 CA406686796	294	A>P		No	ClinGen gnomAD
rs745615935 CA9551191	294	A>V		No	ClinGen ExAC gnomAD
rs1456230245 CA406686801	295	P>A		No	ClinGen gnomAD
rs1478930684 CA406686821	297	K>N		No	ClinGen TOPMed gnomAD
CA406686823 rs1351532074	298	A>P		No	ClinGen gnomAD
TCGA novel	299	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473547984 CA406686840	300	M>T		No	ClinGen TOPMed
rs1436943535 CA406686862	303	T>I		No	ClinGen gnomAD
CA406686861 rs1436943535	303	T>R		No	ClinGen gnomAD
rs535666494 CA9551193	306	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1289193110 CA406686879	306	A>V		No	ClinGen gnomAD
CA9551194 rs201243351	307	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs988219832 CA309306168	310	D>H		No	ClinGen gnomAD
CA406686901 rs988219832	310	D>N		No	ClinGen gnomAD
COSM1318273 CA9551196 rs773527945	311	V>I	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9551197 rs374656254	312	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs554415680 CA9551198	312	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA406686919 rs1489735613	313	V>I		No	ClinGen TOPMed gnomAD
CA9551199 rs774599231	317	S>C		No	ClinGen ExAC TOPMed gnomAD
rs140220072 CA9551200	318	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9551201 rs768208806 COSM3743032	318	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
VAR_046334 rs2302951 CA9551203	319	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs145223989 CA9551202	319	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406686965 rs1405837220	320	E>*		No	ClinGen TOPMed gnomAD
CA406686963 rs1405837220	320	E>K		No	ClinGen TOPMed gnomAD
rs1363537780 CA406687028	325	S>N		No	ClinGen gnomAD
rs140774613 CA9551205	327	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA406687080 rs1285963103	328	D>E		No	ClinGen gnomAD
rs201752779 CA9551207	328	D>G		No	ClinGen ExAC TOPMed gnomAD
rs201752779 CA406687075	328	D>V		No	ClinGen ExAC TOPMed gnomAD
CA406687095 rs1180913607	329	D>E		No	ClinGen TOPMed
CA406687091 rs1601005004	329	D>G		No	ClinGen Ensembl
rs1601004999 CA406687083	329	D>N		No	ClinGen Ensembl
CA9551208 rs778567948	331	A>G		No	ClinGen ExAC gnomAD
CA406687124 rs1444416724	332	L>V		No	ClinGen TOPMed
rs750221357 CA9551209	337	L>V		No	ClinGen ExAC gnomAD
rs372404488 CA406687211	338	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA406687214 COSM998965 rs1344811488	338	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs372404488 CA9551210	338	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1274922675 CA406687249	340	F>L		No	ClinGen gnomAD
CA406687257 rs1436792498	341	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1436792498 CA406687254	341	K>Q		No	ClinGen gnomAD
rs1569080124 CA406687430	342	S>A		No	ClinGen Ensembl
CA406687440 rs1328132367	343	G>S		No	ClinGen TOPMed
rs536926346 CA9551239	345	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA309307588 rs34470836	345	P>L		No	ClinGen gnomAD
CA309307585 rs34470836	345	P>Q		No	ClinGen gnomAD
rs536926346 CA406687470	345	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs777188163 CA9551240	346	V>L		No	ClinGen ExAC gnomAD
CA9551241 rs200748396	347	A>T		No	ClinGen ExAC TOPMed gnomAD
rs752987228 CA309307625	347	A>V		No	ClinGen Ensembl
CA406687481 rs1601005958	348	T>P		No	ClinGen Ensembl
rs1325088242 CA406687488	349	F>L		No	ClinGen gnomAD
CA406687555 rs144509270	353	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144509270 CA9551243	353	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762623800 CA9551244	354	A>D		No	ClinGen ExAC gnomAD
TCGA novel	354	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9551245 rs765966446	356	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765966446 CA406687588	356	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs751367297 CA9551246	357	T>A		No	ClinGen ExAC TOPMed gnomAD
rs745784143 CA9551247	359	V>I	Variant assessed as Somatic; 4.667e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs752659401 CA9551249	360	E>K		No	ClinGen ExAC gnomAD
CA9551252 rs565828207	362	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406687670 rs1601005995	362	H>Y		No	ClinGen Ensembl
CA9551253 rs745897631	363	P>L		No	ClinGen ExAC gnomAD
CA9551254 rs377375944	364	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA406687723 rs1351155961	365	D>A		No	ClinGen TOPMed
CA406687727 rs1383422301	365	D>E		No	ClinGen gnomAD
CA309307709 rs751716557	367	G>E		No	ClinGen TOPMed gnomAD
rs747396458 CA9551256	367	G>R		No	ClinGen ExAC TOPMed gnomAD
CA406687761 rs578057612	368	V>F		No	ClinGen 1000Genomes ExAC gnomAD
rs578057612 CA9551257	368	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA406687811 rs777050100	372	S>A		No	ClinGen ExAC gnomAD
rs755256324 COSM998966 CA9551259	372	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA9551258 rs777050100	372	S>P		No	ClinGen ExAC gnomAD
rs772729812 CA9551261	373	G>A		No	ClinGen ExAC gnomAD
rs772729812 CA406687828	373	G>D		No	ClinGen ExAC gnomAD
CA406687836 rs1211445453	374	A>T		No	ClinGen gnomAD
rs1490117912 CA406687863	376	H>N		No	ClinGen gnomAD
CA9551264 rs774041858	377	Q>H		No	ClinGen ExAC gnomAD
CA9551265 rs759300042	380	Q>*		No	ClinGen ExAC gnomAD
CA9551267 rs752395281	380	Q>H		No	ClinGen ExAC gnomAD
rs767313528 CA9551266	380	Q>R		No	ClinGen ExAC gnomAD
CA406687905 rs1459862616	382	D>N		No	ClinGen gnomAD
CA9551269 rs545560225	384	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1300983767 CA406687927	385	V>A		No	ClinGen gnomAD
CA406687925 rs1423100966	385	V>L		No	ClinGen gnomAD
TCGA novel	386	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9551271 rs146895668	387	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9551270 rs750538304	387	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9551273 rs373816379	390	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs373816379 CA9551272	390	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs377325041 CA9551274	391	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA406687977 rs200076597 CA406687976	393	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA309307793 rs895089660	393	D>N		No	ClinGen gnomAD
rs748857197 CA9551279	394	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1285571446 CA406687983	395	E>K		No	ClinGen TOPMed
rs773915916 CA9551281	397	D>N		No	ClinGen ExAC TOPMed gnomAD
CA9551285 rs775372217	399	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771580285 CA9551284	399	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760482921 CA9551286	400	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA9551289 rs763171131	402	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1334815921 CA406688041	404	P>L		No	ClinGen gnomAD
CA406688076 rs1002184073	409	F>L		No	ClinGen TOPMed gnomAD
CA9551294 rs753109235	410	V>M		No	ClinGen ExAC TOPMed gnomAD
rs756464583 CA9551295	411	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA406688537 rs1262761314	413	G>A		No	ClinGen TOPMed
CA406688556 rs1252529554	414	E>D		No	ClinGen gnomAD
rs1490789468 CA406688545	414	E>K		No	ClinGen TOPMed
CA406688565 rs1292174614	415	T>I		No	ClinGen TOPMed
rs1243090326 CA406688582	416	E>D		No	ClinGen gnomAD
CA9551298 rs771387893	416	E>K		No	ClinGen ExAC TOPMed gnomAD
rs771387893 CA406688572	416	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA406688613 rs1460323654	419	E>K		No	ClinGen gnomAD
rs1569080335 CA406688680	423	H>L		No	ClinGen Ensembl
CA9551300 rs745313012	424	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9551299 rs778508457	424	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1601006214 CA406688704	425	Q>R		No	ClinGen Ensembl
rs1450294811 CA406688758	429	L>H		No	ClinGen gnomAD
CA406688753 rs1405301504	429	L>I		No	ClinGen gnomAD
rs776745728 CA9551305	430	L>P		No	ClinGen ExAC gnomAD
rs761869282 CA9551307	431	V>I		No	ClinGen ExAC TOPMed gnomAD
rs761869282 CA9551306	431	V>L		No	ClinGen ExAC TOPMed gnomAD
CA406688785 rs1473912897	432	S>G		No	ClinGen TOPMed gnomAD
rs751672705 CA9551308	432	S>N		No	ClinGen ExAC gnomAD
rs1173096239 CA406688801	433	T>A		No	ClinGen TOPMed
CA9551309 rs759465666	433	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767845353 CA309310748	434	A>G		No	ClinGen ExAC TOPMed gnomAD
CA9551310 rs767845353	434	A>V		No	ClinGen ExAC TOPMed gnomAD
rs756511758 CA9551312	435	L>P		No	ClinGen ExAC gnomAD
rs955017360 CA309310776	440	I>V		No	ClinGen TOPMed
CA9551315 rs201379668	442	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771216738 CA9551316	442	R>H		No	ClinGen ExAC TOPMed gnomAD
CA406688944 rs1199539716	444	I>M		No	ClinGen gnomAD
rs1601006294 CA406688934	444	I>V		No	ClinGen Ensembl
CA406688952 rs1428049036	445	S>N		No	ClinGen gnomAD
rs768380375 COSM1395025 CA9551321	446	V>A	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs371830640 COSM70993 CA9551319	446	V>I	ovary Variant assessed as Somatic; 5.47e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA9551320 rs371830640	446	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA406688980 rs1452812102	447	V>C		No	ClinGen TOPMed gnomAD

No associated diseases with Q9BQ67

9 regional properties for Q9BQ67

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	203 - 243	IPR001680-1
repeat	WD40 repeat	249 - 292	IPR001680-2
repeat	WD40 repeat	297 - 338	IPR001680-3
repeat	WD40 repeat	342 - 383	IPR001680-4
conserved_site	WD40 repeat, conserved site	323 - 337	IPR019775
repeat	G-protein beta WD-40 repeat	277 - 291	IPR020472-1
repeat	G-protein beta WD-40 repeat	323 - 337	IPR020472-2
repeat	G-protein beta WD-40 repeat	369 - 383	IPR020472-3
domain	Histone-binding protein RBBP4, N-terminal	45 - 112	IPR022052

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus Nucleus Chromosome	Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA replication origin binding	Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
RNA binding	Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name	Definition
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
nucleosome assembly	The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
nucleosome disassembly	The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
ribosome biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAARKGRRRT	CETGEPMEAE	SGDTSSEGPA	QVYLPGRGPP	LREGEELVMD	EEAYVLYHRA
70	80	90	100	110	120
QTGAPCLSFD	IVRDHLGDNR	TELPLTLYLC	AGTQAESAQS	NRLMMLRMHN	LHGTKPPPSE
130	140	150	160	170	180
GSDEEEEEED	EEDEEERKPQ	LELAMVPHYG	GINRVRVSWL	GEEPVAGVWS	EKGQVEVFAL
190	200	210	220	230	240
RRLLQVVEEP	QALAAFLRDE	QAQMKPIFSF	AGHMGEGFAL	DWSPRVTGRL	LTGDCQKNIH
250	260	270	280	290	300
LWTPTDGGSW	HVDQRPFVGH	TRSVEDLQWS	PTENTVFASC	SADASIRIWD	IRAAPSKACM
310	320	330	340	350	360
LTTATAHDGD	VNVISWSRRE	PFLLSGGDDG	ALKIWDLRQF	KSGSPVATFK	QHVAPVTSVE
370	380	390	400	410	420
WHPQDSGVFA	ASGADHQITQ	WDLAVERDPE	AGDVEADPGL	ADLPQQLLFV	HQGETELKEL
430	440
HWHPQCPGLL	VSTALSGFTI	FRTISV