Q9BEG2
Gene name |
IL12RB2 |
Protein name |
Interleukin-12 receptor subunit beta-2 |
Names |
IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282452 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9BEG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9BEG2-F1 | Predicted | AlphaFoldDB |
No variants for Q9BEG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9BEG2 | |||||
No associated diseases with Q9BEG2
6 regional properties for Q9BEG2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Long hematopoietin receptor, Gp130 family 2, conserved site | 401 - 458 | IPR003529 |
| domain | Fibronectin type III | 124 - 217 | IPR003961-1 |
| domain | Fibronectin type III | 224 - 319 | IPR003961-2 |
| domain | Fibronectin type III | 421 - 519 | IPR003961-3 |
| domain | Fibronectin type III | 521 - 620 | IPR003961-4 |
| domain | Immunoglobulin C2-set-like, ligand-binding | 28 - 109 | IPR010457 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| interleukin-12 receptor complex | A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| interleukin-12 binding | Binding to interleukin-12. |
| interleukin-12 receptor activity | Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHTVGGCSL | ALIFIIMLLL | VKAKIDVCKR | GDVTVQPSHV | ISLGSAVNIS | CSLKPKQGCL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSSSFNKLIL | YKFDRRIYVQ | HGHSLSSQVK | GLPLGTTLFV | CKLACSSSDE | IRICGAEISV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVVPEQPRNL | SCIQKGERGT | VTCTWHRGRD | THLYTAYTLQ | LNGPKNLTWQ | KQCNDHYCDH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDLGINLTPE | SLESSYTVKV | TAINSLGSAS | SFPFSFTLLD | IVRPLPPWDI | RIKFVNASVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RCTLLWRDEG | LVLLNRLRYR | PINSRSWNMV | NVTNAKGRHD | LLDLKPFTEY | EFQISSKLHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKGSWSDWSE | SLRTQTPEEE | PIGMLNVWYM | RQHIDYNRQQ | ISLFWKNLSL | SEARGKILHY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVTLQKVAGG | EITLQNITEH | TSWTWVIPRT | GNWAAAVSAA | NSKGSSLPTR | INITDLCGAE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLAPQQVLAK | SEGMDKLMVT | WTPPEKATAA | VQEYVVEWRE | LHPGAGMQPP | LGWLWSPPYR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSALISENIK | PYICYEIRVH | ALAGDQGGCN | STRGNSQHKA | PLSGPHINAI | SEEKGSVLIS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WDEIPAREQM | GCILHYRIYW | KERDSNSQPQ | LCEIPYRISP | NSHPIDSLQP | RVTYVLWMTA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LTAAGESPQG | NEREFCLQGK | ANWSTFVAPS | ICMAVIMVGV | LSMRCFRQKV | FVLLLALRPQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WCSKEIPDPA | NSTWAKKYPI | VEEKTQLALD | RLLTEWPTPE | EPEPLVINEV | LCRVTPVFRP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PHHRSWSEKG | QGVQGHYTSE | EDTGYSASSP | PPPRAPTAET | GQGVDLYKVL | GSKGPDSKPG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NPASPLTILP | VDYLPTHDGY | LPSNMDYLPS | HEAPITDPLE | ELPQHISLSI | FPSSSLRPLT |
| 850 | 860 | ||||
| FSCGEKLTLD | QLKMGCGSLM | L |