Q9BE24
Gene name |
LDHA (QccE-13024, QccE-13248, QflA-14835) |
Protein name |
L-lactate dehydrogenase A chain |
Names |
LDH-A, LDH muscle subunit, LDH-M |
Species |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
KEGG Pathway |
|
EC number |
1.1.1.27: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9BE24
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9BE24-F1 | Predicted | AlphaFoldDB |
No variants for Q9BE24
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9BE24 | |||||
No associated diseases with Q9BE24
4 regional properties for Q9BE24
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 71 - 90 | IPR003583-1 |
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 106 - 125 | IPR003583-2 |
| domain | Holliday junction DNA helicase RuvA, C-terminal | 158 - 202 | IPR011114 |
| domain | DNA helicase, Holliday junction RuvA type, domain I, bacterial | 1 - 60 | IPR013849 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.27 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-lactate dehydrogenase activity | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLKDQLIH | NLLKEEQTPQ | NKITVVGVGA | VGMACAISIL | MKDLADELAL | VDVIEDKLKG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EMMDLQHGSL | FLRTPKIVSG | KDYSVTANSK | LVIITAGARQ | QEGESRLNLV | QRNVNIFKFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPNVVKYSPN | CKLLIVSNPV | DILTYVAWKI | SGFPKNRVIG | SGCNLDSARF | RYLMGERLGV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HPLSCHGWVL | GEHGDSSVPV | WSGMNVAGVS | LKTLHPDLGT | DKDKEQWKEV | HKQVVESAYE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIKLKGYTSW | AIGLSVADLA | ESIMKNLRRV | HPVSTMIKGL | YGIKDDVFLS | VPCILGQNGI |
| 310 | 320 | 330 | |||
| SDLVKVTLTP | EEEARLKKSA | DTLWGIQKEL | QF |