Q9A6Q5

PR
Gene name
thiC (CC_2029)
Protein name
Phosphomethylpyrimidine synthase
Names
Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC
Species
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
KEGG Pathway
ccr:CC_2029
EC number
4.1.99.17: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q9A6Q5

Entry ID Method Resolution Chain Position Source
3EPM X-ray 279 A A/B 1-612 PDB
3EPN X-ray 211 A A/B 1-612 PDB
3EPO X-ray 210 A A/B 1-612 PDB
4S2A X-ray 293 A A 1-612 PDB
AF-Q9A6Q5-F1 Predicted AlphaFoldDB

No variants for Q9A6Q5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9A6Q5

No associated diseases with Q9A6Q5

1 regional properties for Q9A6Q5

Type Name Position InterPro Accession
domain ThiC-associated domain 17 - 72 IPR025747

Functions

Description
EC Number 4.1.99.17 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine.
carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIQSTIKAV AETISTGPIP GSRKVYQAGE LFPELRVPFR EVAVHPSANE PPVTIYDPSG
70 80 90 100 110 120
PYSDPAIQID IEKGLPRTRE ALVVARGDVE EVADPRQVKP EDNGFAQGKH LAPEFPDTGR
130 140 150 160 170 180
KIYRAKPGKL VTQLEYARAG IITAEMEYVA IRENLRREQD RPCVRDGEDF GASIPDFVTP
190 200 210 220 230 240
EFVRQEIARG RAIIPANINH GELEPMAIGR NFLVKINANI GNSAVLSTVA DEVDKLVWAT
250 260 270 280 290 300
RWGADTVMDL STGRNIHNIR DWIIRNSSVP IGTVPIYQAL EKVNGVAEDL NWEVFRDTLI
310 320 330 340 350 360
EQCEQGVDYF TIHAGVRLPF IPMTAKRVTG IVSRGGSIMA KWCLAHHKEN FLYERFDEIC
370 380 390 400 410 420
EIMRAYDVSF SLGDGLRPGS TADANDEAQF SELRTLGELT KVAWKHGVQV MIEGPGHVAM
430 440 450 460 470 480
HKIKANMDEQ LKHCHEAPFY TLGPLTTDIA PGYDHITSAI GAAMIGWFGT AMLCYVTPKE
490 500 510 520 530 540
HLGLPDRDDV KTGVITYKLA AHAADLAKGH PGAAMWDDAI SRARFEFRWE DQFNLGLDPE
550 560 570 580 590 600
TARKFHDETL PKEAHKTAHF CSMCGPKFCS MKISQEVRDF AAGKAPNSAE LGMAEMSEKF
610
REQGSEIYLK TE