Q99TL8

PR
Gene name
relA (SA1460)
Protein name
GTP pyrophosphokinase
Names
(p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I
Species
Staphylococcus aureus (strain N315)
KEGG Pathway
sau:SA1460
EC number
2.7.6.5: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

538-616 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99TL8

Entry ID Method Resolution Chain Position Source
AF-Q99TL8-F1 Predicted AlphaFoldDB

No variants for Q99TL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q99TL8

No associated diseases with Q99TL8

7 regional properties for Q99TL8

Type Name Position InterPro Accession
domain ACT domain 657 - 736 IPR002912
domain HD/PDEase domain 53 - 178 IPR003607
domain TGS 400 - 461 IPR004095
domain HD domain 57 - 156 IPR006674
domain RelA/SpoT 226 - 357 IPR007685
domain RelA/SpoT, TGS domain 403 - 461 IPR033655
domain RelA/SpoT, AH and RIS domains 475 - 638 IPR045600

Functions

Description
EC Number 2.7.6.5 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNGVYHIMNN EYPYSADEVL HKAKSYLSAD EYEYVLKSYH IAYEAHKGQF RKNGLPYIMH
70 80 90 100 110 120
PIQVAGILTE MRLDGPTIVA GFLHDVIEDT PYTFEDVKEM FNEEVARIVD GVTKLKKVKY
130 140 150 160 170 180
RSKEEQQAEN HRKLFIAIAK DVRVILVKLA DRLHNMRTLK AMPREKQIRI SRETLEIYAP
190 200 210 220 230 240
LAHRLGINTI KWELEDTALR YIDNVQYFRI VNLMKKKRSE REAYIETAID RIRTEMDRMN
250 260 270 280 290 300
IEGDINGRPK HIYSIYRKMM KQKKQFDQIF DLLAIRVIVN SINDCYAILG LVHTLWKPMP
310 320 330 340 350 360
GRFKDYIAMP KQNLYQSLHT TVVGPNGDPL EIQIRTFDMH EIAEHGVAAH WAYKEGKKVS
370 380 390 400 410 420
EKDQTYQNKL NWLKELAEAD HTSSDAQEFM ETLKYDLQSD KVYAFTPASD VIELPYGAVP
430 440 450 460 470 480
IDFAYAIHSE VGNKMIGAKV NGKIVPIDYI LQTGDIVEIR TSKHSYGPSR DWLKIVKSSS
490 500 510 520 530 540
AKGKIKSFFK KQDRSSNIEK GRMMVEVEIK EQGFRVEDIL TEKNIQVVNE KYNFANEDDL
550 560 570 580 590 600
FAAVGFGGVT SLQIVNKLTE RQRILDKQRA LNEAQEVTKS LPIKDNIITD SGVYVEGLEN
610 620 630 640 650 660
VLIKLSKCCN PIPGDDIVGY ITKGHGIKVH RTDCPNIKNE TERLINVEWV KSKDATQKYQ
670 680 690 700 710 720
VDLEVTAYDR NGLLNEVLQA VSSTAGNLIK VSGRSDIDKN AIINISVMVK NVNDVYRVVE
730
KIKQLGDVYT VTRVWN