Q99PK0
PR
Gene name |
Xab2 (Ath55) |
Protein name |
Pre-mRNA-splicing factor SYF1 |
Names |
Adapter protein ATH-55, XPA-binding protein 2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:245976 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99PK0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99PK0-F1 | Predicted | AlphaFoldDB |
No variants for Q99PK0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q99PK0 | |||||
No associated diseases with Q99PK0
13 regional properties for Q99PK0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 48 - 80 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 93 - 122 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 124 - 158 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 270 - 305 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 409 - 445 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 447 - 496 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 498 - 530 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 532 - 566 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 571 - 605 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 679 - 713 | IPR003107-10 |
| repeat | Tetratricopeptide repeat | 256 - 289 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 395 - 428 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 433 - 466 | IPR019734-3 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| post-mRNA release spliceosomal complex | A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| blastocyst development | The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. |
| cerebral cortex development | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| generation of catalytic spliceosome for first transesterification step | Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| transcription-coupled nucleotide-excision repair | The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04048 | SYF1 | Pre-mRNA-splicing factor SYF1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9HCS7 | XAB2 | Pre-mRNA-splicing factor SYF1 | Homo sapiens (Human) | PR |
| Q9DCD2 | Xab2 | Pre-mRNA-splicing factor SYF1 | Mus musculus (Mouse) | PR |
| A1A5S1 | Prpf6 | Pre-mRNA-processing factor 6 | Rattus norvegicus (Rat) | PR |
| P63155 | Crnkl1 | Crooked neck-like protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVMARVPRP | ERPDLVFEEE | DLPYEEEIMR | NQFSVKCWLR | YIEFKQGAPK | PRLNQLYERA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKLLPCSYKL | WYRYLKARRA | QVKHRCVTDP | AYEDVNNCHE | RAFVFMHKMP | RLWLDYCQFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MDQGRVTHTR | RTFDRALRAL | PITQHSRIWP | LYLRFLRSHP | LPETAVRGYR | RFLKLSPESA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEYIEYLKSS | DRLDEAAQRL | ATVVNDERFV | SKAGKSNYQL | WHELCDLISQ | NPDKVQSLNV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DAIIRGGLTR | FTDQLGKLWC | SLADYYIRSG | HFEKARDVYE | EAIRTVMTVR | DFTQVFDSYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QFEESMIAAK | METASELGRE | EEDDVDLELR | LARFEQLISR | RPLLLNSVLL | RQNPHHVHEW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HKRVALHQGR | PREIINTYTE | AVQTVDPFKA | TGKPHTLWVA | FAKFYEDNGQ | LDDARVILEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ATKVNFKQVD | DLASVWCQCG | ELELRHENYD | EALKLLRKAT | ALPARRAEYF | DGSEPVQNRV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YKSLKVWSML | ADLEESLGTF | QSTKAVYDRI | LDLRIATPQI | VINYAMFLEE | HKYFEESFKA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YERGISLFKW | PNVSDIWSTY | LTKFISRYGG | RKLERARDLF | EQALDGCPPK | YAKTLYLLYA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLEEEWGLAR | HAMAVYDRAT | RAVEPAQQYD | MFNIYIKRAA | EIYGVTHTRG | IYQKAIEVLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DEHAREMCLR | FADMECKLGE | IDRARAIYSF | CSQICDPRTT | GAFWQTWKDF | EVRHGNEDTI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| REMLRIRRSV | QATYNTQVNF | MASQMLKVSG | SATGTVSDLA | PGQSGMDDMK | LLEQRAEQLA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AEAERDQPPR | AQSKIFFVRS | DASREELAEL | AQQANPEEIQ | LGEDEDEDEM | DLEPNEVRLE |
| 850 | |||||
| QQSVPAAVFG | SLKED |