Q99P88

PR
Gene name
Nup155
Protein name
Nuclear pore complex protein Nup155
Names
155 kDa nucleoporin, Nucleoporin Nup155
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:170762
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

567-667 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99P88

Entry ID Method Resolution Chain Position Source
AF-Q99P88-F1 Predicted AlphaFoldDB

70 variants for Q99P88

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3405510501 18 S>L No EVA
rs223471763 19 L>Q No EVA
rs3389314721 55 P>S No EVA
rs3389368323 64 D>E No EVA
rs13466251 83 T>N No EVA
rs3404966578 107 G>S No EVA
rs3389345793 132 G>D No EVA
rs3389368400 163 H>Y No EVA
rs3389342300 166 V>F No EVA
rs32683973 183 V>A No EVA
rs3389342263 189 I>V No EVA
rs3405723146 193 S>R No EVA
rs3389362595 193 S>R No EVA
rs3405813551 203 D>E No EVA
rs3405303878 237 E>* No EVA
rs3405813506 237 E>D No EVA
rs3405743947 237 E>V No EVA
rs3405035941 240 Y>N No EVA
rs3389333095 256 H>Q No EVA
rs3389350347 258 K>M No EVA
rs3389353223 268 L>V No EVA
rs3389271966 296 E>A No EVA
rs3389362548 305 L>S No EVA
rs261248666 350 S>N No EVA
rs3389353169 357 Q>H No EVA
rs3389333163 357 Q>R No EVA
rs3389304542 407 K>N No EVA
rs3389314755 420 M>V No EVA
rs3389346877 428 N>K No EVA
rs3389346871 430 I>N No EVA
rs3389362592 446 M>L No EVA
rs228704592 534 E>D No EVA
rs3389362564 555 A>T No EVA
rs3389348522 583 R>I No EVA
rs3389304474 600 S>F No EVA
rs3404967580 613 P>H No EVA
rs3389355054 650 S>T No EVA
rs3389333166 653 T>S No EVA
rs3389362575 660 S>L No EVA
rs3389314785 669 Y>* No EVA
rs3389345788 690 S>N No EVA
rs3389350345 691 S>T No EVA
rs3389355027 698 I>N No EVA
rs3389350351 703 P>L No EVA
rs3389350415 728 S>P No EVA
rs3389355048 746 V>I No EVA
rs3389342272 752 E>* No EVA
rs3389353139 767 F>I No EVA
rs3389342307 777 S>L No EVA
rs3389348603 791 A>T No EVA
rs3389314779 824 K>M No EVA
rs3389354983 826 L>P No EVA
rs3389345741 837 L>* No EVA
rs3389323607 877 A>T No EVA
rs3389274447 879 E>D No EVA
rs3389342299 890 K>M No EVA
rs3389350389 952 H>N No EVA
rs3389348568 971 S>T No EVA
rs3389342326 972 Y>H No EVA
rs3389345790 986 S>N No EVA
rs3389333165 1099 S>T No EVA
rs3389304501 1229 L>S No EVA
rs3389368322 1245 S>N No EVA
rs3405751277 1248 L>H No EVA
rs248686672 1290 N>S No EVA
rs263927718 1292 I>V No EVA
rs3389354992 1308 K>N No EVA
rs32683232 1348 R>K No EVA
rs3389342264 1365 Q>R No EVA
rs3405751229 1383 L>F No EVA

No associated diseases with Q99P88

2 regional properties for Q99P88

Type Name Position InterPro Accession
domain Nucleoporin, Nup133/Nup155-like, C-terminal 815 - 1177 IPR007187
domain Nucleoporin, Nup133/Nup155-like, N-terminal 79 - 508 IPR014908

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side
  • In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nuclear pore inner ring A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex.

1 GO annotations of molecular function

Name Definition
structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

10 GO annotations of biological process

Name Definition
atrial cardiac muscle cell action potential An action potential that occurs in an atrial cardiac muscle cell.
miRNA processing A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
protein localization to nuclear inner membrane A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.
protein localization to nucleus A process in which a protein transports or maintains the localization of another protein to the nucleus.
RNA export from nucleus The directed movement of RNA from the nucleus to the cytoplasm.
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75694 NUP155 Nuclear pore complex protein Nup155 Homo sapiens (Human) PR
10 20 30 40 50 60
MPSVLGSMMV ASTSAAASLQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNSPTVSGM
70 80 90 100 110 120
SDMDYPLQGP GLLSVPSLPE ISTIRRVPLP PELVEQFGHM QCNCMMGVFP PISRAWLTID
130 140 150 160 170 180
SDIFMWNYED GGDLAYFDGL SETILAVGLV KPKAGIFQPH VRHLLVLATP VDIVILGLSY
190 200 210 220 230 240
ANVQTGSGIL NDSMCGGMQL LPDPLYSLPT DNTYLLTITS TDNGRIFLAG KDGCLYEVAY
250 260 270 280 290 300
QAEAGWFSQR CRKINHSKSS LSFLVPSLLQ FTFSEDDPIV QIEIDNSRNI LYTRSEKGVI
310 320 330 340 350 360
QVYDLGHDGQ GMSRVASVSQ NAIVSAAGNI ARTIDRSVFK PIVQIAVIES SESLDCQLLA
370 380 390 400 410 420
VTHAGVRLYF STCPFRQPLA RPNTLTLVHV RLPPGFSASS TVEKPSKVHK ALYSKGILLM
430 440 450 460 470 480
TASENEDNDI LWCVNHDTFP FQKPMMETQM TTRVDGHSWA LSAIDELKVD KIITPLNKDH
490 500 510 520 530 540
IPITDSPVVV QQHMLPPKKF VLLSAQGSLM FHKLRPVDQL RHLLVSNVGG DGEEIERFFK
550 560 570 580 590 600
LHQEDQACAT CLILACSTAA CDREVSAWAT RAFFRYGGEA QMRFPATLPT PSNVGPILGS
610 620 630 640 650 660
PMYSSSPVPS GSPYPNPSSL GTPSHGAQPP TMSTPMCAVG SPAMQAASMS GLTGPEIVYS
670 680 690 700 710 720
GKHNGICIYF SRIMGNIWDA SLVVERVFKS SNREITAIES SVPVQLLESV LQELKGLQEF
730 740 750 760 770 780
LDRNSQFSGG PLGNPNTTAR VQQRLVGFMR PENGNTQQMQ QELQRKFQEA QLSEKISLQA
790 800 810 820 830 840
IQQLVRKSYQ ALALWKLLCE HQFSVIVGEL QKEFQEQLKI TTFKDLVIRD KEVTGALIAS
850 860 870 880 890 900
LINCYIRDNA AVDGISLHLQ DTCPLLYSTD DAVCSKANEL LQRSRQVQSK TERERMLRES
910 920 930 940 950 960
LKEYQKISNQ VDLPSVCAQY RQVRFYEGVV ELSLTAAEKK DPQGLGLHFY KHGEPEEDVV
970 980 990 1000 1010 1020
GLQTFQERLN SYKCITDTLQ ELVNQSKAAP QSPSVPKKPG PPVLSSDPNM LSNEEAGHHF
1030 1040 1050 1060 1070 1080
EQMLKLAQRS KDELFSIALY NWLIQADLAD KLLQIASPFL EPHLVRMARV DQNRVRYMDL
1090 1100 1110 1120 1130 1140
LWRYYEKNRS FSSAARVLSK LADMHSTEIS LQQRLEYIAR AILSAKSSTA ISSIAADGEF
1150 1160 1170 1180 1190 1200
LHELEEKMEV ARIQLQIQET LQRQYSHHSS VQDAISQLDS ELMDITKLYG EFADPFKLAE
1210 1220 1230 1240 1250 1260
CKLAVIHCAG YSDPILVHTL WQDIIEKELN DSVALSSSDR MHALSLKLVL LGKIYAGTPR
1270 1280 1290 1300 1310 1320
FFPLDFIVQF LEQQVCTLNW DVGFVIQTMN EIGVPLPRLL EVYDQLFKSR DPFWNRVKSP
1330 1340 1350 1360 1370 1380
LHLLDCIHVL LTRYVENPSL VLNCERRRFT NLCLDAVCGY LVELQSMSSS VAVQAITGNF
1390
KSLQAKLERL H