Q99MP8
Gene name |
Brap |
Protein name |
BRCA1-associated protein |
Names |
BRAP2, Impedes mitogenic signal propagation, IMP, RING-type E3 ubiquitin transferase BRAP2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72399 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99MP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99MP8-F1 | Predicted | AlphaFoldDB |
15 variants for Q99MP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs261290263 | 20 | T>A | No | EVA | |
| rs3396274791 | 30 | E>D | No | EVA | |
| rs3388777901 | 93 | P>L | No | EVA | |
| rs3388770410 | 159 | S>N | No | EVA | |
| rs3388777948 | 305 | C>Y | No | EVA | |
| rs3388788848 | 309 | E>D | No | EVA | |
| rs3388780676 | 339 | Y>C | No | EVA | |
| rs3388789287 | 347 | H>R | No | EVA | |
| rs3388795968 | 352 | Q>H | No | EVA | |
| rs3388786967 | 360 | T>I | No | EVA | |
| rs3388789069 | 398 | E>K | No | EVA | |
| rs3388789151 | 398 | E>V | No | EVA | |
| rs3388785892 | 417 | S>W | No | EVA | |
| rs3388780673 | 451 | C>G | No | EVA | |
| rs3396160313 | 547 | H>L | No | EVA |
No associated diseases with Q99MP8
1 regional properties for Q99MP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycosyl transferase, family 1 | 226 - 392 | IPR001296 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ubiquitin ligase complex | A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| nuclear localization sequence binding | Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| nucleic acid binding | Binding to a nucleic acid. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSLVVIRL | ELAGHSPVPT | DFGFSAAAGE | MSDEEIKKKT | LASAVACLEG | KSAGEKAAII |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HQHLGRREMT | DVIIETMKAR | ADEVRDTVEE | KKPSAAPVSA | QRSREQSESV | NTAPESPSKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPDQISFFSG | NPSVEIVHGI | MHLYKTNKMT | SLKEDVRRSA | MLCVLTVPAT | MTSHDLMKFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APFNDVIEQM | KIIRDSTPNQ | YMVLIKFSAQ | ADADSFYMAC | NGRQFNSIED | DVCQLVYVER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEVLKSEDGA | SLPVMDLTEL | PKCTVCLERM | DESVNGILTT | LCNHSFHSQC | LQRWDDTTCP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VCRYCQTPEP | VEENKCFECG | VQENLWICLI | CGHIGCGRYV | SRHAYKHFEE | TQHTYAMQLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NHRVWDYAGD | NYVHRLVASK | TDGKIVQYEC | EGDTCQEEKI | DALQLEYSYL | LTSQLESQRI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YWENKIVRIE | KDTAEEINNM | KTKFKETIEK | CDSLELRLSD | LLKEKQSVER | KCTQLNTRVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLSTELQEEQ | ELNKCLRANQ | LVLQNQLKEE | EKLLKETCAQ | KDLQITEIQE | QLRDVMFYLE |
| 550 | 560 | 570 | 580 | 590 | |
| TQQQISHLPA | ETRQEIQEGQ | INIAMASAPN | PPSSGAGGKL | QSRKGRSKRG | K |