Q99LH1
Gene name |
Gnl2 |
Protein name |
Nucleolar GTP-binding protein 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:230737 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99LH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99LH1-F1 | Predicted | AlphaFoldDB |
27 variants for Q99LH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388705397 | 3 | K>N | No | EVA | |
| rs3388712043 | 35 | R>Q | No | EVA | |
| rs3388708852 | 115 | K>T | No | EVA | |
| rs3388705012 | 124 | R>Q | No | EVA | |
| rs3388712118 | 148 | S>A | No | EVA | |
| rs3388709410 | 166 | N>K | No | EVA | |
| rs3388704971 | 172 | E>K | No | EVA | |
| rs3388705388 | 233 | R>C | No | EVA | |
| rs3388715453 | 295 | I>N | No | EVA | |
| rs3388709379 | 307 | D>Y | No | EVA | |
| rs3388715428 | 317 | G>V | No | EVA | |
| rs3388710396 | 325 | S>Y | No | EVA | |
| rs3388709361 | 346 | K>N | No | EVA | |
| rs3388704969 | 414 | S>T | No | EVA | |
| rs3388705416 | 456 | I>V | No | EVA | |
| rs3388715479 | 464 | N>I | No | EVA | |
| rs27553216 | 467 | L>I | No | EVA | |
| rs250990920 | 562 | G>A | No | EVA | |
| rs259634028 | 580 | R>C | No | EVA | |
| rs3388703387 | 590 | G>E | No | EVA | |
| rs3388698823 | 618 | K>R | No | EVA | |
| rs3388712092 | 636 | Y>* | No | EVA | |
| rs3388712923 | 639 | E>K | No | EVA | |
| rs3388709390 | 645 | E>* | No | EVA | |
| rs27553197 | 646 | D>V | No | EVA | |
| rs3388712086 | 692 | G>C | No | EVA | |
| rs3388712059 | 701 | V>L | No | EVA |
No associated diseases with Q99LH1
4 regional properties for Q99LH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GTP binding domain | 313 - 415 | IPR006073 |
| domain | Nucleolar GTP-binding protein 2, N-terminal domain | 43 - 174 | IPR012971 |
| domain | Nucleolar GTP-binding protein 2, circularly permuted GTPase motif | 209 - 365 | IPR024929 |
| domain | Circularly permuted (CP)-type guanine nucleotide-binding (G) domain | 207 - 368 | IPR030378 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8CI11 | Gnl3 | Guanine nucleotide-binding protein-like 3 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKPKYKGRS | TINRSAASTN | PDRVQGAGGQ | NMRDRGTIRR | LNMYRQKERR | NSRGKVIKPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QYQSTVASGT | VARVEPNIKW | FGNTRVIKQA | SLQKFQEEMD | KVMKDPYKVV | MKQSKLPMSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHDRIQPHNA | KVHILDTESF | ESTFGPKSQR | KRPNLFASDM | QSLLENAEMS | TESYDQGKDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLVMEDTGVR | NEAQEEIYKK | GQSKRIWGEL | YKVIDSSDVV | VQVLDARDPM | GTRSPHIEAY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKKEKPWKHL | IFVLNKCDLV | PTWATKRWVA | VLSQDYPTLA | FHASLTNPFG | KGAFIQLLRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FGKLHTDKKQ | ISVGFIGYPN | VGKSSVINTL | RSKKVCNVAP | IAGETKVWQY | ITLMRRIFLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DCPGVVYPSE | DSETDIVLKG | VVQVEKIKAP | QDHIGAVLER | AKPEYISKTY | KIESWENAED |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLEKLALRTG | KLLKGGEPDM | LTVSKMVLND | WQRGRIPFFV | KPPNAELPTD | SQLPPSSPLE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VPTETTQNNP | EEETTETEVE | RSDSITEKEP | EGDCSQDRNS | EMQQILARVR | QNFGKINVGP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QFSADDLVPV | EMSDLEDLES | SGEEEEQEQE | QPGEDAEEER | SPDTQEEPVG | NDTKAVLRAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DEKIAKYQRF | LNKAKAKKFS | AVRISKDLSE | KVFAKYKEEK | KTSAEDSDAA | PTKKARKWDA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QMEEEPSNKT | QRMLTCKERR | RAARQQQSKK | VGVRYYETHN | VKNRNRNKKK | TSDSEGQKHR |
| RNKFRQKQ |