Q99L45

PR
Gene name
Eif2s2
Protein name
Eukaryotic translation initiation factor 2 subunit 2
Names
Eukaryotic translation initiation factor 2 subunit beta, eIF-2-beta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67204
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99L45

Entry ID Method Resolution Chain Position Source
AF-Q99L45-F1 Predicted AlphaFoldDB

11 variants for Q99L45

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388598584 4 D>V No EVA
rs3388603975 24 M>L No EVA
rs3388599648 28 E>K No EVA
rs3388596961 39 S>* No EVA
rs3388605280 51 E>K No EVA
rs3392128369 167 G>V No EVA
rs3388596965 278 T>N No EVA
rs3388594462 302 T>I No EVA
rs3388599667 310 A>S No EVA
rs3392419998 320 T>I No EVA
rs3388606093 332 N>L No EVA

No associated diseases with Q99L45

1 regional properties for Q99L45

Type Name Position InterPro Accession
domain Translation initiation factor IF2/IF5 domain 195 - 306 IPR002735

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.

5 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
male germ cell proliferation The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD AQTEETQPSE TKEVEPEPTE EKDVDADEED
70 80 90 100 110 120
SRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEAIKD VKIESDAQEP AEPEDDLDIM
130 140 150 160 170 180
LGNKKKKKKN VKFPEEDEIL EKDEALEDED SKKDDGISFS SQTAWAGSER DYTYEELLNR
190 200 210 220 230 240
VFNIMREKNP DMVAGEKRKF VMKPPQVVRV GTKKTSFVNF TDICKLLHRQ PKHLLAFLLA
250 260 270 280 290 300
ELGTSGSIDG NNQLVIKGRF QQKQIENVLR RYIKEYVTCH TCRSPDTILQ KDTRLYFLQC
310 320 330
ETCHSRCSVA SIKTGFQAVT GKRAQLRAKA N