Q99AU3

PR
Gene name
NS
Protein name
Non-structural protein 1
Names
NS1, NS1A
Species
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

179-230 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q99AU3

Entry ID Method Resolution Chain Position Source
2N74 NMR - A/B 1-73 PDB
5UL6 X-ray 145 A M 210-221 PDB
6ATV X-ray 175 A M 210-221 PDB
6DGK X-ray 190 A A/B 86-205 PDB
6NU0 NMR - A 1-230 PDB
6OX7 X-ray 275 A A/B 86-230 PDB
6U28 X-ray 295 A A/B 86-230 PDB

No variants for Q99AU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q99AU3

No associated diseases with Q99AU3

2 regional properties for Q99AU3

Type Name Position InterPro Accession
domain NUDIX hydrolase domain 23 - 158 IPR000086
domain Diphosphoinositol polyphosphate phosphohydrolase-like, NUDIX domain 26 - 151 IPR047198

Functions

Description
EC Number
Subcellular Localization
  • Host nucleus
  • Host cytoplasm
  • In uninfected, transfected cells, NS1 is localized in the nucleus
  • Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

2 GO annotations of molecular function

Name Definition
protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
suppression by virus of host mRNA processing Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
suppression by virus of host PKR signaling Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response.
suppression by virus of host type I interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSNTVSSFQ VDCFLWHVRK RFADQELGDA PFLDRLRRDQ KSLRGRGSTL GLDIETATRA
70 80 90 100 110 120
GKQIVERILK EESDEALKMT IASVPASRYL TDMTLEEMSR DWFMLMPKQK VAGSLCIRMD
130 140 150 160 170 180
QAIMDKNIIL KANFSVIFDR LETLILLRAF TEEGAIVGEI SPLPSLPGHT DEDVKNAVGV
190 200 210 220
LIGGLEWNDN TVRVSETLQR FAWRSSNENG RPPLPPKQKR KMARTIKSEV