Q99207

PR
Gene name
NOP14 (UTP2, YDL148C, D1566)
Protein name
Nucleolar complex protein 14
Names
U three protein 2, U3 small nucleolar RNA-associated protein 2, U3 snoRNA-associated protein 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL148C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

24 structures for Q99207

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A ST 1-810 PDB
6KE6 EM 340 A RN 1-810 PDB
6LQP EM 320 A RN 1-810 PDB
6LQQ EM 410 A RN 1-810 PDB
6LQR EM 860 A RN 1-810 PDB
6LQS EM 380 A RN 1-810 PDB
6LQT EM 490 A RN 1-810 PDB
6LQU EM 370 A RN 1-810 PDB
6LQV EM 480 A RN 1-810 PDB
6ZQA EM 440 A UB 1-810 PDB
6ZQB EM 390 A UB 1-810 PDB
6ZQC EM 380 A UB 1-810 PDB
6ZQD EM 380 A UB 1-810 PDB
6ZQE EM 710 A UB 1-810 PDB
6ZQF EM 490 A UB 1-810 PDB
6ZQG EM 350 A UB 1-810 PDB
7AJT EM 460 A UB 1-810 PDB
7AJU EM 380 A UB 1-810 PDB
7D4I EM 400 A RN 1-810 PDB
7D5S EM 460 A RN 1-810 PDB
7D5T EM 600 A RN 1-810 PDB
7D63 EM 1230 A RN 1-810 PDB
7SUK EM 399 A ST 1-806 PDB
AF-Q99207-F1 Predicted AlphaFoldDB

11 variants for Q99207

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-190362 76 A>T No SGRP
s04-190268 107 N>S No SGRP
s04-190117 157 D>E No SGRP
s04-190036 184 D>E No SGRP
s04-189503 362 G>D No SGRP
s04-189145 481 M>I No SGRP
s04-189101 496 G>D No SGRP
s04-188812 592 R>S No SGRP
s04-188775 605 D>N No SGRP
s04-188735 618 T>I No SGRP
s04-188505 695 T>S No SGRP

No associated diseases with Q99207

No regional properties for Q99207

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q99207

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
Noc4p-Nop14p complex A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
U3 snoRNA binding Binding to a U3 small nucleolar RNA.

8 GO annotations of biological process

Name Definition
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGSQLKNLK AALKARGLTG QTNVKSKNKK NSKRQAKEYD REEKKKAIAE IREEFNPFEI
70 80 90 100 110 120
KAARNKRRDG LPSKTADRIA VGKPGISKQI GEEQRKRAFE ARKMMKNKRG GVIDKRFGER
130 140 150 160 170 180
DKLLTEEEKM LERFTRERQS QSKRNANLFN LEDDEDDGDM FGDGLTHLGQ SLSLEDELAN
190 200 210 220 230 240
DEEDFLASKR FNEDDAELQQ PQRKKTKAEV MKEVIAKSKF YKQERQKAQG IMEDQIDNLD
250 260 270 280 290 300
DNFEDVMSEL MMTQPKKNPM EPKTDLDKEY DIKVKELQLD KRAAPSDRTK TEEEKNAEAE
310 320 330 340 350 360
EKKRELEQQR LDRMNGMIEL EEGEERGVED LDDGFWENEE DYEDDNDGIA DSDDDIKFED
370 380 390 400 410 420
QGRDEGFSQI LKKKNISISC PRTHDALLDQ VKKLDLDDHP KIVKNIIKAY QPKLAEGNKE
430 440 450 460 470 480
KLGKFTAVLL RHIIFLSNQN YLKNVQSFKR TQNALISILK SLSEKYNREL SEECRDYINE
490 500 510 520 530 540
MQARYKKNHF DALSNGDLVF FSIIGILFST SDQYHLVITP ALILMSQFLE QIKFNSLKRI
550 560 570 580 590 600
AFGAVLVRIV SQYQRISKRY IPEVVYFFQK ILLTFIVEKE NQEKPLDFEN IRLDSYELGL
610 620 630 640 650 660
PLDVDFTKKR STIIPLHTLS TMDTEAHPVD QCVSVLLNVM ESLDATISTV WKSLPAFNEI
670 680 690 700 710 720
ILPIQQLLSA YTSKYSDFEK PRNILNKVEK LTKFTEHIPL ALQNHKPVSI PTHAPKYEEN
730 740 750 760 770 780
FNPDKKSYDP DRTRSEINKM KAQLKKERKF TMKEIRKDAK FEARQRIEEK NKESSDYHAK
790 800
MAHIVNTINT EEGAEKNKYE RERKLRGGKK