Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q99189

Entry ID Method Resolution Chain Position Source
AF-Q99189-F1 Predicted AlphaFoldDB

20 variants for Q99189

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-633845 2 D>E No SGRP
s15-634308 157 S>P No SGRP
s15-634429 197 S>N No SGRP
s15-634571 244 E>D No SGRP
s15-634960 374 S>C No SGRP
s15-634983 382 N>D No SGRP
s15-635170 444 S>N No SGRP
s15-635178 447 I>L No SGRP
s15-635239 467 N>S No SGRP
s15-635242 468 T>I No SGRP
s15-635322 495 G>S No SGRP
s15-635683 615 K>R No SGRP
s15-635835 666 T>A No SGRP
s15-635838 667 L>M No SGRP
s15-635863 675 T>I No SGRP
s15-636268 810 A>V No SGRP
s15-636298 820 Y>S No SGRP
s15-636423 862 E>K No SGRP
s15-636435 866 A>T No SGRP
s15-636571 911 T>I No SGRP

No associated diseases with Q99189

2 regional properties for Q99189

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 28 - 97 IPR001494
domain Exportin-1/Importin-beta-like 100 - 253 IPR013598

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
small GTPase binding Binding to a small monomeric GTPase.

5 GO annotations of biological process

Name Definition
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
RNA import into nucleus The import of RNA from the cytoplasm to the nucleus.
RNA localization A process in which RNA is transported to, or maintained in, a specific location.
snRNA import into nucleus The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus.
tRNA transport The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS KEDPTNALLE
70 80 90 100 110 120
LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ KLIITQLNVA LARLAIQFLE
130 140 150 160 170 180
WQNPIFEIIS LLNSSPSILL NFLRILPEET LDIASTSLTE VEFNSRIHEL IDPIAEDVLK
190 200 210 220 230 240
FLVSCIDLLQ NTDGNSSSSI SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE
250 260 270 280 290 300
SDMEAFDSAI DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD
310 320 330 340 350 360
LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT FPFWFNFKQS
370 380 390 400 410 420
LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE EDKFKDFRYH MGDVLKDCTA
430 440 450 460 470 480
VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA PLFSLRTMAK EISLTENTIL PEIIKIICNL
490 500 510 520 530 540
PEQAKIRYAS TLVLGRYTEW TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM
550 560 570 580 590 600
FFCSDCSKLL VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV
610 620 630 640 650 660
DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS EPLLPRIEFI
670 680 690 700 710 720
WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP ILPSVAEFLI QGYLTTGFGS
730 740 750 760 770 780
YLWCSGSLIV IFGDDESFPI SPSLKDAVWK FALSQCETFI LNFNKFDKLQ LNDYHEAIID
790 800 810 820 830 840
FFSLISDLIM FYPGAFLNST ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT
850 860 870 880 890 900
PPISTVSIEI VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR
910 920 930 940 950 960
ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK VREGIRAFVG
970
WYSRKNINSR FE