Q98ST7

PR
Gene name
MOXD1 (DBHR, MOX)
Protein name
DBH-like monooxygenase protein 1
Names
DBH-related protein, Monooxygenase X
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395333
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

126-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q98ST7

Entry ID Method Resolution Chain Position Source
AF-Q98ST7-F1 Predicted AlphaFoldDB

No variants for Q98ST7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q98ST7

No associated diseases with Q98ST7

4 regional properties for Q98ST7

Type Name Position InterPro Accession
domain Copper type II, ascorbate-dependent monooxygenase, N-terminal 187 - 313 IPR000323
domain DOMON domain 35 - 148 IPR005018
domain Copper type II ascorbate-dependent monooxygenase, C-terminal 334 - 482 IPR024548
domain Copper-dependent monooxygenases, DOMON domain 31 - 165 IPR045266

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
secretory granule membrane The lipid bilayer surrounding a secretory granule.

2 GO annotations of molecular function

Name Definition
copper ion binding Binding to a copper (Cu) ion.
dopamine beta-monooxygenase activity Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.

3 GO annotations of biological process

Name Definition
dopamine catabolic process The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
norepinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.
octopamine biosynthetic process The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRPLRPWALL LGALLGAAAA AARRYPHVAV LDGAAAYRLL WGRRGSALAF RLEVRTRGYV
70 80 90 100 110 120
GFGLSAGGGM ASADIVVGGV EGGRPYLQDY HTDENRVLKK DPQQDYHLEY AMENSTHTIL
130 140 150 160 170 180
AFSRELYTCD PNDKSITEST VRVIWAYHHK DLGEAGQNYH GSTRGTKSLR LLNPEKAEVS
190 200 210 220 230 240
PASLSYFDLT NKDVPVPDKD TTYWCQMFKI PVQHEKHHVT KVEPLIQKDH ENLVHHILLY
250 260 270 280 290 300
QCSSNLNDSV LDYGHECYHP NMPDSFFTCE TVIFAWAIGG EGFTYPPHVG LSIGTAADPQ
310 320 330 340 350 360
FVLMEVHYDN PTYTEGLIDN SGLRLFYTPV LRKYDAGVIE AGLWVSLFHN IPPGMPEFVS
370 380 390 400 410 420
EGHCTLECLE EALGAERPSG IHVFAVLLHA HLAGRAIRMR HFRNGEEQKL LAYDEEFDFN
430 440 450 460 470 480
FQEFQYLEEE RTIMPGDNLI TECHYSTTDR IRMTWGGLST RNEMCLSYLL YYPRINLTRC
490 500 510 520 530 540
ASIPDIMEQL QFIGVKEIYR PVRTWPFIIK SPKQYKNLSF MDAMNKFKWS KSEGLSYNEL
550 560 570 580 590 600
VLKLPMNVRC SKTDNAEWSF QGMTAFPPEV ERPYKTEPVI CSSSSCLPCS LSLTLLFVVY
610
VASSTIGNFG PVVQ