Q98RB6

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis)
KEGG Pathway
mpu:MYPU_0930
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

251-324 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q98RB6

Entry ID Method Resolution Chain Position Source
AF-Q98RB6-F1 Predicted AlphaFoldDB

No variants for Q98RB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q98RB6

No associated diseases with Q98RB6

4 regional properties for Q98RB6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 414 - 615 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 653 - 768 IPR013155
domain Methionyl/Leucyl tRNA synthetase 36 - 168 IPR015413
domain Leucyl-tRNA synthetase, editing domain 222 - 400 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYNHKEIEKK WQKIWDQSKA FKTGNKSDKK YYVLDMFPYP SGSGLHVGHP EGYTATDIIA
70 80 90 100 110 120
RFKRLKGFDV LHPMGWDAFG LPAEQYAIST GNNPNEFTQK NIATFKKQIK SLGLSYDFDK
130 140 150 160 170 180
EVNTTDPKFY EQTQWIFKEL YKKGLAVLAD IDVNWCEELG TVLANEEVLI DKDGNKVSER
190 200 210 220 230 240
GSFPVVKKKM RQWVLKITNY ADKLLEGLED LDWENSLKLL QKNWIGKSTG TKVKFALELL
250 260 270 280 290 300
DESIEVFTTR IETIFGATFL TISPEHPLVE KIVTSENKEK VKDFIKEFEK LDDRQKADKN
310 320 330 340 350 360
EKNGIFTGSY AINPFNQKKI PIWIGDFVLL SYGTGAIMSV PAHDKRDYEF ANKYGLEIKQ
370 380 390 400 410 420
VIVSKENVEL PYLESGHLIN SSEFNGLSSK EAIEKLNQYV EKNNLGQVET FYKLRDWIFS
430 440 450 460 470 480
RQRYWGEPFP VAFDDENNVY LIDGLVELPF MENIKPSKNG QSPLFNNKKW LYFEKDGKKL
490 500 510 520 530 540
TRETNTMPQW AGSNWYYLAY ILKNADGSYE KLDSEEAKKR FKKWLPVDLY IGGQEHAVLH
550 560 570 580 590 600
LLYSRFWHRF LYDIGVVPTK EPFQKVVNQG MILGTDGQKM SKSRGNIINP SEIVDELGAD
610 620 630 640 650 660
TLRVYEMFMG PLTDDKDWQV ESIKGIRKWL ERVYRLFEMF FDGQKTIEKS NEDHLILSQY
670 680 690 700 710 720
NKLIKEIENE VELLKFNTAI SKLMVFVNLL YKVEKIPSWE ILKNFALILS LFAPHIAEEL
730 740 750 760 770 780
LEKMNQKQVK DQIWPTYDPT YLESNLTKYV IQINGKVRAI VDFELDKTQE EVLAKAMQIE
790 800
KIKTLLENKN IIKVIFVANK VLNLIVK