Q98HN3
Gene name |
leuA |
Protein name |
2-isopropylmalate synthase |
Names |
Alpha-IPM synthase, Alpha-isopropylmalate synthase |
Species |
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) |
KEGG Pathway |
mlo:mlr2792 |
EC number |
2.3.3.13: Acyl groups converted into alkyl groups on transfer |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q98HN3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q98HN3-F1 | Predicted | AlphaFoldDB |
No variants for Q98HN3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q98HN3 | |||||
No associated diseases with Q98HN3
5 regional properties for Q98HN3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pyruvate carboxyltransferase | 30 - 307 | IPR000891 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 37 - 53 | IPR002034-1 |
| conserved_site | Alpha-isopropylmalate/homocitrate synthase, conserved site | 239 - 252 | IPR002034-2 |
| domain | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 420 - 553 | IPR013709 |
| domain | LeuA, N-terminal catalytic TIM barrel domain | 29 - 311 | IPR039371 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.3.13 | Acyl groups converted into alkyl groups on transfer |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-isopropylmalate synthase activity | Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| leucine biosynthetic process | The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPDAARKYQP | YPTVGLTDRT | WPNKVIDKAP | IWCSVDLRDG | NQALIDPMGH | ERKARMFGLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDMGFKEIEI | GFPSASQTDF | DFARWCIEEG | NVPADVSLQV | LVQCRPELIT | RTFEALKGAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPIVHFYNST | SELQRRVVFE | KDVGGIKRIA | TDAAKMITDM | AAKAGGGYRF | EYSPESFTGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELEVALEICN | AVTEIVRPKP | DNKLIINLPS | TVEMSTPNIY | ADRIEWMCRN | LDNRENLIIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHPHNDRGTG | IATTELGLMA | GADRVEGTLF | GNGERTGNVD | IVTLALNMYT | QGVDPGIDCS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DINRMKDVYE | YSNQLKIPER | HPYVGELVYT | AFSGSHQDAI | NKGMKALKKA | NTSLWEVPYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PIDPADVGRS | YEAIIRINSQ | SGKGGIAYVL | QADYGLNLPR | NLQIEFSQAI | QAITDAEGKE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VPAKRIHERF | LETYVDQPGA | RLKFLDHHTY | PDTAVKGRRV | IEAVILDKGK | EVTISGTGTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PIDGFVDALS | RHVGVEMSVL | DYSEHSMQRG | SNASAISYVE | MEYPGGKLFG | AGINTNIVAA |
| 550 | |||||
| SLEAVTSAAN | RIVGRKAR |