Q983U5

PR
Gene name
fumC
Protein name
Fumarate hydratase class II
Names
Fumarase C, Aerobic fumarase, Iron-independent fumarase
Species
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
KEGG Pathway
mlo:mll8172
EC number
4.2.1.2: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-351 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q983U5

Entry ID Method Resolution Chain Position Source
AF-Q983U5-F1 Predicted AlphaFoldDB

No variants for Q983U5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q983U5

No associated diseases with Q983U5

9 regional properties for Q983U5

Type Name Position InterPro Accession
domain Elongation factor EFG, domain V-like 600 - 687 IPR000640
domain Translational (tr)-type GTP-binding domain 10 - 285 IPR000795
domain Translation elongation factor EFTu-like, domain 2 324 - 391 IPR004161
domain Small GTP-binding protein domain 11 - 182 IPR005225
domain Translation elongation factor EFG/EF2, domain IV 479 - 598 IPR005517
domain Elongation factor G, domain III 405 - 480 IPR009022
conserved_site Tr-type G domain, conserved site 53 - 68 IPR031157
domain EFG, domain V 603 - 680 IPR035649
domain Elongation Factor G, domain II 404 - 478 IPR041095

Functions

Description
EC Number 4.2.1.2 Hydro-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle.

1 GO annotations of molecular function

Name Definition
fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O.

2 GO annotations of biological process

Name Definition
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVAKTRTET DTFGPIEVAA DRYWGAQAQR SLGNFKIGWE KQPASIVRAL GVVKRAAAEV
70 80 90 100 110 120
NMEMKRLDPV VGKAIVDAAQ EVIDGKLNDH FPLVVWQTGS GTQSNMNANE VISNRAIEML
130 140 150 160 170 180
GGVMGSKKPV HPNDHVNMSQ SSNDTYPTAM HIACAEQVVH HLIPALHHLH KALDAKARAF
190 200 210 220 230 240
NHIIKIGRTH TQDATPLTLG QEFSGYAAQV ASSIKRIEMT LPGLQELAQG GTAVGTGLNA
250 260 270 280 290 300
PVGFAEKVAD RIAAITGIAF VTAPNKFEAL AAHDSMVFSH GAINAAAAAL FKIANDIRFL
310 320 330 340 350 360
GSGPRSGLGE LSLPENEPGS SIMPGKVNPT QCEAMTQVCV QVFGNNAALT FAGSQGHFEL
370 380 390 400 410 420
NVYNPLMAYN FLQSVQLLSD ASVSFTDNCV VGIEAREDNI KAALDRSLML VTALAPTIGY
430 440 450 460
DNAAKIAKTA HKNGTTLREE ALATGLVSEV DYDRLVRPED MTHPG