Q983N4
Gene name |
ileS |
Protein name |
Isoleucine--tRNA ligase |
Names |
Isoleucyl-tRNA synthetase, IleRS |
Species |
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099)) |
KEGG Pathway |
mlo:mlr8250 |
EC number |
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q983N4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q983N4-F1 | Predicted | AlphaFoldDB |
No variants for Q983N4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q983N4 | |||||
No associated diseases with Q983N4
4 regional properties for Q983N4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 64 - 75 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 35 - 699 | IPR002300 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 744 - 892 | IPR013155 |
| domain | Isoleucyl tRNA synthetase type 1, anticodon-binding domain | 700 - 864 | IPR033708 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.5 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| isoleucine-tRNA ligase activity | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| isoleucyl-tRNA aminoacylation | The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDTVETIDY | SKTLYLPQTD | FPMRAGLPEK | EPVLVKRWQD | MDLYAKLRES | AAGRTKYVLH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGPPYANGNI | HIGHALNKIL | KDVITRSFQM | RGYDSTYVPG | WDCHGLPIEW | KIEEQYRAKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNKDEVPVNE | FRKECREFAA | HWITVQGGEF | QRLGVIGDFK | NPYTTMAFHA | ESRIAGELLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FALSGQLYRG | SKPVMWSVVE | RTALAEAEIE | YQDYESDTIW | AKFPVANLVV | ANVVDGQPAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNPDLSDRSL | DLLDAHVVIW | TTTPWTIPGN | RAVSYSPRVA | YGLYEVTAAE | NAFGPEPGEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIFADALAAE | SQAKAKITLK | RLHHVSAEQL | GNLVLSHPFK | GLGGGYEFPV | PMVAGDHVTD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DAGTGFVHTA | PGHGREDFDA | WMDAAPQLRA | RGIDTVIPFT | VDDAGFFTRD | APGFGPDREG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GAARVIDDNG | KKGNANQAVI | DELIKRNALF | ARGRLKHSYP | HSWRSKKPVI | FRNTPQWFVY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MDKDLGDGTT | LRSRALKAID | DTRFVPAAGQ | NRIRAMIEER | PDWVLSRQRA | WGVPIAVFAD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EDGNVLKDEA | VNQRIMDAFE | EEGADAWFAA | GAKERFLGNH | DASKWKQVMD | ILDVWFDSGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| THVFTLEDRP | DLKWPADVYL | EGSDQHRGWF | HSSLLESCGT | RGRAPYDTVV | THGFTMDEDG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RKMSKSLGNT | VVPQDVIKQS | GADILRLWVV | TTDYWEDQRL | GKNVLQTNID | AYRKLRNTIR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WMLGTLAHDD | GETVPLEAMP | ELERLMLHRL | AELDEVVRQG | YDAFEFKRIT | RALVDFMVVE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LSAFYFDIRK | DALYCDAPSS | VKRKASVQVV | RHLFDCLVKW | LAPMLPFTME | EAWLDRHPDA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VSVHLDQFPE | IPADWKNEAL | AEKWRKVRQV | RRVVTGALEI | ARAQKVIGSS | LEAVPVVTIN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DAALEAAIAD | VDMAEMAITS | DLVIAHGQAP | EGAFTLDDVR | GVAVVVEKAE | DRGLVKCARS |
| 970 | 980 | 990 | |||
| WRYTADVGQD | PAFPDVSARD | AAVLHELKAL | GRL |