Q97Z86

PR
Gene name
prs
Protein name
Ribose-phosphate pyrophosphokinase
Names
RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO1045
EC number
2.7.6.1: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q97Z86

Entry ID Method Resolution Chain Position Source
4TWB X-ray 280 A A/B/C/D/E/F 1-291 PDB
AF-Q97Z86-F1 Predicted AlphaFoldDB

No variants for Q97Z86

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q97Z86

No associated diseases with Q97Z86

2 regional properties for Q97Z86

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 146 - 265 IPR000836
domain Ribose-phosphate pyrophosphokinase, N-terminal domain 1 - 117 IPR029099

Functions

Description
EC Number 2.7.6.1 Diphosphotransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ribose phosphate diphosphokinase complex A protein complex having ribose phosphate diphosphokinase activity.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

4 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIIGGSATN GIDESLSKIL SIPLVKVENK IFPDGESYIR VPSSIRDEEV LLVQTTDYPQ
70 80 90 100 110 120
DKHLIELFLI AETIRDLGAK KLTAIVPYLA YSRQDRRFKD GEAISIKTIL HILSEVGVNT
130 140 150 160 170 180
LVVVEPHKPE ELSYFKGELK IVHPYHQIAR KIKEIIEDPF ILAPDRGALD RARKIAEEIN
190 200 210 220 230 240
APYSYIEKER DRTTGEVRIK EAPNINLKGK DVVIIDDIIS TGGTIVQATR LAYSLGAKSV
250 260 270 280 290
TAAAIHLLLV GGAKERLREV GVKTLIGTNT INVNDKDIIT IDVSQSIALS L