Q97UL5

PR
Gene name
SSO2989
Protein name
Diphosphomevalonate decarboxylase
Names
DMD
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO2989
EC number
4.1.1.33: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

158-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q97UL5

Entry ID Method Resolution Chain Position Source
4Z7C X-ray 220 A A 2-325 PDB
4Z7Y X-ray 270 A A/B/C/D/E/F 2-325 PDB
5GMD X-ray 150 A A 1-325 PDB
5GME X-ray 170 A A 1-325 PDB
AF-Q97UL5-F1 Predicted AlphaFoldDB

No variants for Q97UL5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q97UL5

No associated diseases with Q97UL5

2 regional properties for Q97UL5

Type Name Position InterPro Accession
domain GHMP kinase N-terminal domain 92 - 149 IPR006204
domain Mvd1, C-terminal 181 - 304 IPR041431

Functions

Description
EC Number 4.1.1.33 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diphosphomevalonate decarboxylase activity Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.

1 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, mevalonate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKSVTVSAP SNIAVVKYWG KRGDERLNLP LNNSLSITLD DQLSVITKVT LNDKNIVIVN
70 80 90 100 110 120
DRILSEDEMK EYAGRVLDTF KKIVGKEFHV KVESKSKFPI NAGLASSAAG IAALAFSLNE
130 140 150 160 170 180
LLELNLKSEE LSKIARLGSG SACRSMFGGF VVWNKGERED GEDSYCYQIF RHDYWSELVD
190 200 210 220 230 240
IIPILSEKEK KISSRKGMIR SAETSELMEC RLKYIEKTFN EVIEAIRNRD EKKFYYLMMR
250 260 270 280 290 300
HSNSMHAVIL DSWPSFFYLN DTSIRIMEWI HDYGKAGYTF DAGPNPHIFT TERNIGDILE
310 320
FLKSLEIKRI IVSKVGDGPK VLSRE