Q97TX6

PR
Gene name
trpB2 (SSO1145)
Protein name
Tryptophan synthase beta chain 2
Names
Species
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
KEGG Pathway
sso:SSO1145
EC number
4.2.1.20: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q97TX6

Entry ID Method Resolution Chain Position Source
4QYS X-ray 194 A A/B 1-429 PDB
6HTE X-ray 196 A B/D 4-428 PDB
AF-Q97TX6-F1 Predicted AlphaFoldDB

No variants for Q97TX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q97TX6

No associated diseases with Q97TX6

1 regional properties for Q97TX6

Type Name Position InterPro Accession
domain SAM-dependent methyltransferase TRM5/TYW2-type 125 - 381 IPR030382

Functions

Description
EC Number 4.2.1.20 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
tryptophan synthase activity Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAMRIRIDLP QDEIPAQWYN ILPDLPEELP PPQDPTGKSL ELLKEVLPSK VLELEFAKER
70 80 90 100 110 120
YVKIPDEVLE RYLQVGRPTP IIRAKRLEEY LGNNIKIYLK MESYTYTGSH KINSALAHVY
130 140 150 160 170 180
YAKLDNAKFV TTETGAGQWG SSVALASALF RMKAHIFMVR TSYYAKPYRK YMMQMYGAEV
190 200 210 220 230 240
HPSPSDLTEF GRQLLAKDSN HPGSLGIAIS DAVEYAHKNG GKYVVGSVVN SDIMFKTIAG
250 260 270 280 290 300
MEAKKQMELI GEDPDYIIGV VGGGSNYAAL AYPFLGDELR SGKVRRKYIA SGSSEVPKMT
310 320 330 340 350 360
KGVYKYDYPD TAKLLPMLKM YTIGSDFVPP PVYAGGLRYH GVAPTLSLLI SKGIVQARDY
370 380 390 400 410 420
SQEESFKWAK LFSELEGYIP APETSHALPI LAEIAEEAKK SGERKTVLVS FSGHGLLDLG
NYASVLFKE