Q97IG3

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
KEGG Pathway
cac:CA_C1678
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

135-213 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q97IG3

Entry ID Method Resolution Chain Position Source
AF-Q97IG3-F1 Predicted AlphaFoldDB

No variants for Q97IG3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q97IG3

No associated diseases with Q97IG3

4 regional properties for Q97IG3

Type Name Position InterPro Accession
domain DHHA1 domain 737 - 872 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 657 - 700 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 713 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKYMGLNDIR ESYLSFFEKK EHLRLPSFSL IPKNDKSLLL INAGMAPLKP YFTGLQTPPK
70 80 90 100 110 120
TRVTTCQKCI RTGDIENIGK TSRHGTFFEM LGNFSFGDYF KEEVISWAWE YITEVLKFPK
130 140 150 160 170 180
DRIYITIYLD DDEAFKIWTE KAGVDPSRIF RFGKEDNFWE HGSGPCGPCS EMHFDRREKP
190 200 210 220 230 240
DLIKTREKFI ELQDKDEVIE FWNLVFTQFD KDEDGNYNKL KNPNIDTGMG LERIATIMQN
250 260 270 280 290 300
TDSIFEIDTI REVLDAVCKI CNVKYGENHK NDVSLRIITD HIRSVTFMIS DGILPSNEGR
310 320 330 340 350 360
GYVLRRLLRR AARHGKTLGI EKTFLCGLCD VVIKNSKGAY KELEEKQDYI KNVIEIEEKR
370 380 390 400 410 420
FDETLDSGME ILKNYIDELS LENKKVMSGE KAFRLYDTYG FPVELTQEIL EEKGIEIDMN
430 440 450 460 470 480
DFHSEMEKQK NRARDAREES NYMGKEIKLI DKLPESVTTK FVGYNSTSTD SKVEVLIKDD
490 500 510 520 530 540
EFVSTINEGE SGIVVTEETP FYAEMGGQIG DKGIIFGKNG EAKVVDCKNN ISGKIIHIVQ
550 560 570 580 590 600
VVKGSIEKNE NVTLEVNYKK RKDICKNHTA THMLQAALKK VVGSHINQSG SYVDNERLRF
610 620 630 640 650 660
DFTHFTALTD EEILKVEAMV NDEIMAAYDV KTDIMSVDEA KKTGAMALFD EKYGNRVRVV
670 680 690 700 710 720
SVGDFSRELC GGTHVNNSGE IGLFKIISES GVAAGIRRIE AITGKEAVRY TEENDNLIRN
730 740 750 760 770 780
IEQELKCSKK DILNKINQYH SELKEKEKEI NILKGKLASG FEENILSSVK EVSGVKYVAS
790 800 810 820 830 840
EVKGISGDTL RELCDKVRNK IDDGMVLLAS KDGEKVQFVA MASKNAVKKG VHCGKVIKEV
850 860 870 880
ASMCGGNGGG RPDMAQAGGK DGEKLETALK EVGNIMEKLV K