Q97CR6

PR
Gene name
polC (TV0035, TVG0041370)
Protein name
DNA polymerase II large subunit
Names
Pol II, Exodeoxyribonuclease large subunit
Species
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
KEGG Pathway
tvo:TVG0041370
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q97CR6

Entry ID Method Resolution Chain Position Source
AF-Q97CR6-F1 Predicted AlphaFoldDB

No variants for Q97CR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q97CR6

No associated diseases with Q97CR6

1 regional properties for Q97CR6

Type Name Position InterPro Accession
domain DNA polymerase II large subunit DP2, N-terminal 18 - 833 IPR016033

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
exodeoxyribonuclease I activity Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides.

2 GO annotations of biological process

Name Definition
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTILHSTMLS EVLDLESYRK KISDEVRECF DLASQARELG MDVTDKVEIP LASDMAERIE
70 80 90 100 110 120
ALIGISGIAD QIRDLSKKMS REEVSLEMSR RVANIFKDNK KEALDKAIRV GLAILTEGIL
130 140 150 160 170 180
VAPLEGIADV YIGKNADGSD YVGISYAGPI RGAGGTAQAL SVLIGDVVRR ELGITRYIPT
190 200 210 220 230 240
EEEIERYIEE IESYDRIKHL QYLPTPDEIK LVVKNSPVCI DGEGSEEEEV SGHRDMARVK
250 260 270 280 290 300
TNRIRGGMCL VLCEGLVQKA RKILKYTSSM HLEEWSFLSS ISGKSDDKGS KKSDKFLKDI
310 320 330 340 350 360
VAGRPVFSHP SRPGGFRLRY GRSRVSGLAA ASLNPATMYI MGKFIAIGSQ IKVELPGKAA
370 380 390 400 410 420
AVTPCDTIDG PTVLLRNGDH VKINNIEKAK ELYDEVVEIT DAGEILIAYG DFLENNYNLP
430 440 450 460 470 480
TASFTKEWWM QYLPDGLDGN EVDQFRAVEL SRQYNIPLHP DFDYYWHDIS FEELEYLISA
490 500 510 520 530 540
VENGRLSDNS FLIPYSASEV LIKLGVQFKR SGNFLVLNQY YPLLVSLGYD VFEDKIKRVK
550 560 570 580 590 600
PYQRKSSVLE TVNYLSGITI KPRAPTRVGS RLGRPEKAGD RKMKPMVHSL FPVESYGEAR
610 620 630 640 650 660
RSILNANKKT DGTYKAEVFF YRCTSCGYES PSPTCPKCGS RSKPIGTKNS EIDLSVILRK
670 680 690 700 710 720
AEDRLGIKLD ELKEFKGVKK LMSKEKVAEP IEKGILRAIH GISVNKDGTC RFDMSDIPIT
730 740 750 760 770 780
HFRYKEIGIS KEKLSELGYE VKDVNEIFPQ DVIIPRKAAK YLFDVSKFID DLLVRYYGLP
790 800 810 820 830 840
PFYSLKSEED LVGHLVIGLA PHTSGGVVGR IIGFSDVNAF YAHPFFHAAK RRNCDGDEDS
850 860 870 880 890 900
VMLLMDGFLN FSARYLPSTT GGLMDAPLVL SVLINPDEID KEALNVDTLQ KYPLIFYEAT
910 920 930 940 950 960
ERHAAPSELE ETMMTMKVRI KKTATYRNSS YTFDTSDINK GVLVSSYKTL ATMDDKISEQ
970 980 990 1000 1010 1020
LGLARRIRAV DADDVAARVI STHFLPDMYG NFRRFFSQEF RCTKCNAKYR RIPLSGRCMK
1030 1040 1050 1060 1070 1080
CGSDSLTLTI HKGSVIKYLD ETLKIEKEYN IPKYLKERID NLARTIKETF PDEEKPDAAI
KITGLDMY