Q971S5

PR
Gene name
STK_13010
Protein name
Homocitrate synthase
Names
HCS
Species
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
KEGG Pathway
sto:STK_13010
EC number
2.3.3.14: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

349-425 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q971S5

Entry ID Method Resolution Chain Position Source
AF-Q971S5-F1 Predicted AlphaFoldDB

No variants for Q971S5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q971S5

No associated diseases with Q971S5

3 regional properties for Q971S5

Type Name Position InterPro Accession
domain Pyruvate carboxyltransferase 3 - 264 IPR000891
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 194 - 207 IPR002034
domain Transcription regulator AsnC/Lrp, ligand binding domain 388 - 458 IPR019887

Functions

Description
EC Number 2.3.3.14 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
homocitrate synthase activity Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
lysine biosynthetic process via aminoadipic acid The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVGILDSTL REGEQTPGVV FTIDQRVEIA KALSDVGVQM IEAGHPAVSS DIYEGIKRIM
70 80 90 100 110 120
KLKREGLITS EIVGHSRAVK KDIEVAAELE VDRIAIFYGV SDIHLKAKHH VTREEALNII
130 140 150 160 170 180
AETISYAKSH GVKVRFTAED GSRTDLDYLI KVCKTARDAG ADRVSIADTV GILYPTKTRE
190 200 210 220 230 240
LFSTLVREVP GLEFDIHAHN DLGLAVANAL AAIEGGATII HTTVNGLGER VGIVPLQVIA
250 260 270 280 290 300
AAIKYHFGIE VVKLNKLQQL ASLVEKYSGI PMPPNYPITG DYAFIHKAGI HVAGVLNDPS
310 320 330 340 350 360
TYEFMPPETF GRSRDYVIDK YTGKHALKDR FEKLGVKLSD VELDQVLAKI KSNPNVRFYR
370 380 390 400 410 420
DVDLLEIAES VTGRVLKPKP PENIEALISV KCESNVYTTA VTRRLSVIPG VKEVMEISGD
430 440 450
YDILVKVEAK DPNELNQIIE NIRAVKGVSS TLTSLVLKKM