Q96WV1

PR
Gene name
trm8 (SPCPB16A4.04c)
Protein name
tRNA (guanine-N(7)-)-methyltransferase
Names
Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCPB16A4.04c
EC number
2.1.1.33: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q96WV1

Entry ID Method Resolution Chain Position Source
AF-Q96WV1-F1 Predicted AlphaFoldDB

No variants for Q96WV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96WV1

No associated diseases with Q96WV1

No regional properties for Q96WV1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q96WV1

Functions

Description
EC Number 2.1.1.33 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
tRNA (m7G46) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat).
tRNA methyltransferase complex A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.

2 GO annotations of molecular function

Name Definition
tRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine.
tRNA binding Binding to a transfer RNA.

4 GO annotations of biological process

Name Definition
RNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule.
tRNA (guanine-N7)-methylation The process whereby a guanine in a tRNA is methylated at the N7 position of guanine.
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSATAKKSAA QLQREEEEAR KKLKRLSKQG GVEGRLPMKR LFRQRAHANV LSDHELEYPR
70 80 90 100 110 120
SPSEMDWSPY YPDFDVESNK KVEIVDIGCG YGGLTVALGP QFPDTLVLGM EIRMQVSDYL
130 140 150 160 170 180
KEKIQALRYR ADHEEPVPGG YKNISVLRMN CQKFLPNFFE KGQLSKMFFC FPDPHFKARK
190 200 210 220 230 240
HKNRIITSTL ASEYAYFIRP HGTLYTITDV EELHVWMAQH LDAHPLFRRF TKEEEENDIC
250 260 270
VTLMTNETEE GKKVARNGGK KFVACYERIP NPK