Q96WJ0

PR
Gene name
ERG7
Protein name
Lanosterol synthase
Names
2,3-epoxysqualene--lanosterol cyclase, Oxidosqualene--lanosterol cyclase, OSC
Species
Pneumocystis carinii
KEGG Pathway
EC number
5.4.99.7: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-99 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q96WJ0

Entry ID Method Resolution Chain Position Source
AF-Q96WJ0-F1 Predicted AlphaFoldDB

No variants for Q96WJ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96WJ0

No associated diseases with Q96WJ0

3 regional properties for Q96WJ0

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 569 - 583 IPR002365
domain Squalene cyclase, C-terminal 382 - 713 IPR032696
domain Squalene cyclase, N-terminal 80 - 333 IPR032697

Functions

Description
EC Number 5.4.99.7 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

1 GO annotations of molecular function

Name Definition
lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.

2 GO annotations of biological process

Name Definition
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIYGYTEKEL EKTDPDGWRL IVEDTGRQRW KYLKTEEERR ERPQTYMEKY FLGKNMDLPE
70 80 90 100 110 120
QPAAKTPIES ARKGFSFYKH LQTSDGNWAC EYGGVMFLLP GLIIAMYISK IEFPDEMRIE
130 140 150 160 170 180
VIRYLVNHAN PEDGGWGIHI EGKSTVFGTA LNYVVLRILG LGPDHPVTMK ARIRLNELGG
190 200 210 220 230 240
AIGCPQWGKF WLAVLNCYGW EGINPILPEF WMLPEWLPIH PSRWWVHTRA VYLPMGYIYG
250 260 270 280 290 300
EKFTAPVDPL IESLREELYT QPYSSINFSK HRNTTSPVDV YVPHTRFLRV INSILTFYHT
310 320 330 340 350 360
IFRFSWIKDM ASKYAYKLIE YENKNTDFLC IGPVNFSIHI LAVYWKEGPD SYAFKSHKER
370 380 390 400 410 420
MADFLWISKK GMMMNGTNGV QLWDTSFAVQ ALVESGLAED PEFKDHMIKA LDFLDKCQIQ
430 440 450 460 470 480
KNCDDQQKCY RHRRKGAWPF STRQQGYTVS DCTAEALKAV LLLQNLKSFP KRVSYDRLKD
490 500 510 520 530 540
SVDVILSLQN KDGGFASYEL IRGPSWLEFI NPAEVFGDIM IEHSYPECTT AAVTALCYFR
550 560 570 580 590 600
SLCSHYRGPE INKSVKNAIQ FIKESQRPDG SWYESWAICF TYATMFALES LSCVKDFYEN
610 620 630 640 650 660
SFHSRRACDF LVNKQEEDGG WSEGYQSCTD GIWTRHPTGS QVVQTAWACI GLMYANYPDE
670 680 690 700 710
TPIKRGINLI MSRQQPNGEW KQEAIEGVFN KNCMISYPNY KFNFTIKALG MYSKRYGNI