Q96VK3

PR
Gene name
ptkA (bur1, AN8865)
Protein name
Serine/threonine-protein kinase bur1
Names
PITALRE-like kinase A
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN8865.2
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

328-449 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

172-206 (Activation loop from InterPro)

Target domain

25-326 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q96VK3

Entry ID Method Resolution Chain Position Source
AF-Q96VK3-F1 Predicted AlphaFoldDB

No variants for Q96VK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96VK3

No associated diseases with Q96VK3

3 regional properties for Q96VK3

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 326 IPR000719
active_site Serine/threonine-protein kinase, active site 151 - 163 IPR008271
binding_site Protein kinase, ATP binding site 31 - 54 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

4 GO annotations of biological process

Name Definition
phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
protein phosphorylation The process of introducing a phosphate group on to a protein.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIASLERDT KGGTRFTGCT SIREFEFLGK LGEGTFGEVY KARAKRDGSI VALKKILMHN
70 80 90 100 110 120
ERDGFPITAL REIKLLKMLS HTNIMQLREM AVERSKGEGR KKPSMYMVFP YMEHDLSGLL
130 140 150 160 170 180
ENPEVHFSEA QIKCYMIQLL EGLKYLHGNC ILHRDMKAAN LLISNQGILQ IADFGLARPF
190 200 210 220 230 240
DEAPPQPGKG AGEAKRDYTT LVVTRWYRPP ELLLQLRRYT SAIDMWGVGC VFGEMFKGKP
250 260 270 280 290 300
ILAGNSDLNQ AQLIFSLVGT PTEENMPGWS SLPGCEGVKH FGNRPGNLAE VFKDQGPMAI
310 320 330 340 350 360
SLLTELLKLD WRKRVNAIDA LKHPYFSTPP LPARPGDLPS FEDSHELDRR RFRGQRAAMP
370 380 390 400 410 420
PAPAGGSVGM SRNGGWSTNS GSRTGAETRN PRISSAARSQ GNQLRDAWSN EPQQAWQRRG
430 440 450 460 470 480
NEELKDPNHS FSSRHRDGGL PPKPPAPIQH SWASGHSDKT GRDRGYGARY GGPEGSVDSY
490 500 510 520 530 540
VPNYGGSDRN RDRDQGTAIS DRRGSYYDKS HQTSKLDYSR EIPSRRRSRS PNYRERVDRG
PYRR