Q96UX3

PR
Gene name
pkaR (AFUA_3G10000)
Protein name
cAMP-dependent protein kinase regulatory subunit
Names
PKA regulatory subunit
Species
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KEGG Pathway
afm:AFUA_3G10000
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-176 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q96UX3

Entry ID Method Resolution Chain Position Source
AF-Q96UX3-F1 Predicted AlphaFoldDB

No variants for Q96UX3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96UX3

No associated diseases with Q96UX3

No regional properties for Q96UX3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q96UX3

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cAMP-dependent protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A.

6 GO annotations of biological process

Name Definition
asexual sporulation resulting in formation of a cellular spore The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
negative regulation of cAMP-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
negative regulation of nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
positive regulation of asexual sporulation resulting in formation of a cellular spore Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADSSSFPGT NPFLKVSTKD DKYSPIQKIS EEEEYEVTSP TDPTFRSAHS GATAPTAGNS
70 80 90 100 110 120
FNGDNGSNEG GEGIQFNRPF DAGFGQGSEG QGEHVEPPGG ARPTAAANQG FPNNYALGRR
130 140 150 160 170 180
TSVSAESLNP TSAGSDSWTP PCHPKTEEQL SRLKTAVSNN FLFSHLDDDQ FRTVLDALVE
190 200 210 220 230 240
KPIPAKDIKV ISQGDAGDYF YIVENGHFDV YINPAGSVQP GPDGIGNKVS TIGPGGSFGE
250 260 270 280 290 300
LALMYNAPRA ATIVSADPKS TLWALDRITF RRILMDSAFQ RRRMYEAFLE EVPLLSSLKP
310 320 330 340 350 360
YERAKIADAL DAIKYPAGST IIEEGAPGDA FYLLESGEAE AFKKDVEGPV KSYRRGDFFG
370 380 390 400 410
ELALLDDKPR AASVVAKTDV KVARLGRDGF KRLLGPVEDI MRRAEYSAKP SPS