AiPD: Autoinhibited Protein Database

Q96LI9

Gene name	CXorf58
Protein name	Uncharacterized protein CXorf58
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:254158
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-48 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96LI9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96LI9-F1	Predicted				AlphaFoldDB

194 variants for Q96LI9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1235553978 CA412590586	2	N>K		No	ClinGen TOPMed gnomAD
CA327668731 rs141234868	3	R>C		No	ClinGen ESP TOPMed gnomAD
rs141234868 CA327668730	3	R>G		No	ClinGen ESP TOPMed gnomAD
CA412590590 rs1488548529	3	R>H		No	ClinGen TOPMed
rs1370878886 CA412590603	5	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10370239 rs139980314	7	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412590624 rs764370346	9	R>C		No	ClinGen ExAC gnomAD
rs764370346 CA10370240	9	R>S		No	ClinGen ExAC gnomAD
rs1468131181 CA412590636	11	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10370241 rs754032781	11	G>V		No	ClinGen ExAC TOPMed gnomAD
CA10370243 rs765187437	12	I>N		No	ClinGen ExAC gnomAD
CA10370245 rs149951169	21	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	23	V>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_029857 rs2707164 CA10370247	24	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA412590720 rs2707164	24	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA412590723 rs1439613806	24	R>H		No	ClinGen gnomAD
CA412590722 rs1439613806	24	R>L		No	ClinGen gnomAD
CA10370248 rs755363601	26	V>I		No	ClinGen ExAC gnomAD
COSM1467286 rs147890788 CA10370250 COSM1467285	29	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs769461268 CA10370251	32	R>*		No	ClinGen ExAC TOPMed gnomAD
rs772530059 CA10370252	33	N>H		No	ClinGen ExAC gnomAD
CA412590787 rs1406909092	34	A>V		No	ClinGen TOPMed
rs1366211431 CA412590799	36	S>L		No	ClinGen TOPMed
rs78304044 CA10370256	39	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10370255 rs199875318	39	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1339971400 CA412590835	40	M>I		No	ClinGen TOPMed
CA412590830 rs1219739290	40	M>V		No	ClinGen TOPMed
CA412590840 rs1355145644	41	L>F		No	ClinGen TOPMed gnomAD
CA412590839 rs1355145644	41	L>V		No	ClinGen TOPMed gnomAD
CA10370269 rs755415158	42	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10370270 rs761858937	46	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA10370271 rs747807328	46	A>V		No	ClinGen ExAC TOPMed gnomAD
rs755770526 CA10370272	47	Q>R		No	ClinGen ExAC gnomAD
CA10370274 rs748817043	50	Q>*		No	ClinGen ExAC gnomAD
CA10370275 rs770446581	50	Q>R		No	ClinGen ExAC gnomAD
CA412590903 rs1474736437	51	R>G		No	ClinGen gnomAD
rs1185378652 CA412590915	52	A>V		No	ClinGen gnomAD
TCGA novel	56	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	56	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1472864604 CA412590947	57	T>A		No	ClinGen gnomAD
rs151084387 CA327668827	57	T>I		No	ClinGen ESP gnomAD
rs1382068254 CA412590955	58	N>S		No	ClinGen gnomAD
COSM1119376 rs1391932597 CA412590992 COSM1599159	63	R>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1402958155 CA412591018	67	H>R		No	ClinGen TOPMed gnomAD
CA327668828 rs771855729	68	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10370278 rs771855729	68	A>T		No	ClinGen ExAC TOPMed gnomAD
rs937911528 CA327668829	68	A>V		No	ClinGen TOPMed
CA327668830 rs770088156	69	I>V		No	ClinGen TOPMed
rs760447315	72	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA10370279 rs749982754	72	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10370286 rs376953518	75	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA327669144 rs984100716	78	H>P		No	ClinGen TOPMed gnomAD
CA10370288 rs753173434	79	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10370289 rs756498282	80	I>M		No	ClinGen ExAC
rs1394972095 CA412591138	83	K>N		No	ClinGen gnomAD
CA412591147 rs1315157393	85	A>S		No	ClinGen gnomAD
rs1315157393 CA412591145	85	A>T		No	ClinGen gnomAD
CA327669145 rs909431548	85	A>V		No	ClinGen TOPMed
CA10370293 rs778358348	88	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10370294 rs745814457	88	E>V		No	ClinGen ExAC TOPMed gnomAD
CA412591169 rs1412620008	89	A>T		No	ClinGen TOPMed
rs772050247 CA10370295	92	I>V		No	ClinGen ExAC gnomAD
CA412591196 rs1347053829	93	K>E		No	ClinGen TOPMed gnomAD
CA327669148 rs941677682	94	D>N		No	ClinGen TOPMed gnomAD
rs779959401 CA10370296	98	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1259211374 CA412591241	99	C>Y		No	ClinGen TOPMed
rs768207006 CA10370304	109	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1398872332 CA412591346	112	P>L		No	ClinGen gnomAD
rs1466269682 CA412591350	113	F>S		No	ClinGen gnomAD
CA10370307 rs764473329	114	I>L		No	ClinGen ExAC TOPMed gnomAD
CA10370308 rs764473329	114	I>V		No	ClinGen ExAC TOPMed gnomAD
CA10370310 rs144611010	115	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA10370311 rs749999780	116	F>L		No	ClinGen ExAC gnomAD
TCGA novel	118	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757870174 CA10370312	122	T>A		No	ClinGen ExAC gnomAD
CA327669173 rs563545258	123	D>N		No	ClinGen Ensembl
rs780014397 CA10370313	126	G>S		No	ClinGen ExAC gnomAD
rs1456019989 CA412591465	130	F>L		No	ClinGen TOPMed
CA327669174 rs761533023	135	V>I		No	ClinGen 1000Genomes TOPMed gnomAD
CA412591502 rs761533023	135	V>L		No	ClinGen 1000Genomes TOPMed gnomAD
TCGA novel	137	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138423407 CA10370318	138	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138423407 CA10370319	138	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs747488230 CA10370342	144	D>G		No	ClinGen ExAC TOPMed gnomAD
rs149276385 CA10370343	146	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1362249081 CA412591599	147	C>*		No	ClinGen gnomAD
CA412591613 rs1400361820	149	L>R		No	ClinGen gnomAD
CA412591618 rs1353177386	150	M>T		No	ClinGen TOPMed gnomAD
CA10370344 rs776970311	155	F>C		No	ClinGen ExAC gnomAD
rs1312827279 CA412591663	156	H>R		No	ClinGen TOPMed gnomAD
CA10370345 rs113172105	157	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10370346 rs765534922 COSM166928	157	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA412591673 rs1288755331	158	I>V		No	ClinGen gnomAD
rs780859887 CA327669947	159	I>T		No	ClinGen 1000Genomes
CA10370347 rs772880794	164	R>C		No	ClinGen ExAC gnomAD
rs762524721 CA10370348	164	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs375112667 CA10370349	165	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs752200961 CA10370350	167	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA327669948 rs1010224065	167	P>S		No	ClinGen Ensembl
CA412591747 rs1230723502	169	S>T		No	ClinGen TOPMed
TCGA novel	171	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10370353 rs780411850	174	I>T		No	ClinGen ExAC TOPMed gnomAD
rs751467045 CA327669949	177	V>I		No	ClinGen Ensembl
rs1156831958 CA412591820	179	T>I		No	ClinGen gnomAD
CA10370354 rs186677792	180	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1420150874 CA412591846	183	Y>D		No	ClinGen TOPMed gnomAD
rs1420150874 CA412591847	183	Y>H		No	ClinGen TOPMed gnomAD
rs777674169 CA10370356	184	V>G		No	ClinGen ExAC gnomAD
rs1266544331 CA412591862	185	Q>R		No	ClinGen TOPMed gnomAD
rs1376903341 CA412592069	186	Y>C		No	ClinGen gnomAD
CA10370371 rs372943491	187	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs16982852 VAR_029858 CA10370372	187	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1220152009 CA412592089	188	S>N		No	ClinGen TOPMed gnomAD
CA10370373 rs752714645	189	F>V		No	ClinGen ExAC TOPMed gnomAD
CA412592125 rs369303661	191	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10370375 rs369303661	191	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs866886877 CA327670514	193	A>D		No	ClinGen Ensembl
rs1254160722 CA412592177	195	A>E		No	ClinGen TOPMed
rs1453901753 CA412592168	195	A>T		No	ClinGen TOPMed
TCGA novel	197	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753748456 CA10370376	198	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10370378 rs780368307	199	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1244877019 CA412592238	201	N>S		No	ClinGen gnomAD
rs1191542694 CA412592290 COSM1467290 COSM1467289	205	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1418453985 CA412592292	205	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs375708749 CA327670515	208	N>S		No	ClinGen Ensembl
TCGA novel	209	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	211	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA327670518 rs946448605	212	I>S		No	ClinGen TOPMed gnomAD
CA327670517 rs946448605	212	I>T		No	ClinGen TOPMed gnomAD
CA412592385 rs1172319069	213	P>R		No	ClinGen gnomAD
CA412592378 rs1601971433	213	P>T		No	ClinGen Ensembl
rs147217789 CA412592390	214	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA412592404 rs1443644473	215	T>S		No	ClinGen gnomAD
rs371158194 CA10370382	218	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs778248163 CA10370384	221	I>V		No	ClinGen ExAC gnomAD
rs771179658 CA10370386	227	S>P		No	ClinGen ExAC gnomAD
rs140614869 CA10370387	233	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1026306543 CA327670519	233	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
COSM3037077 rs771619651 COSM3037076 CA10370389	235	R>*	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10370390 rs775086373	235	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA412592641 rs1222125644	236	N>S		No	ClinGen gnomAD
rs150830689 CA10370392	244	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10370393 rs764164047	245	P>L		No	ClinGen ExAC gnomAD
COSM1119390 CA10370395 rs761720174	247	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751809793 CA10370397	250	I>M		No	ClinGen ExAC TOPMed gnomAD
CA10370398 rs755097364	253	H>L		No	ClinGen ExAC TOPMed gnomAD
rs755097364 CA412592850	253	H>R		No	ClinGen ExAC TOPMed gnomAD
CA412592875 rs1402201957	255	L>I		No	ClinGen gnomAD
CA10370401 rs760908965	256	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10370400 rs570262107	256	R>W		No	ClinGen ExAC gnomAD
CA412592888 rs1569256240	257	I>V		No	ClinGen Ensembl
CA412592905 rs1193912601	258	V>A		No	ClinGen TOPMed
rs760843941 CA10370403	259	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	262	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1394537849 CA412593492	263	G>S		No	ClinGen gnomAD
CA10370412 rs776737577	264	P>S		No	ClinGen ExAC gnomAD
CA412593507 rs1265085121	265	Y>C		No	ClinGen TOPMed
rs774226096 CA10370415	270	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10370417 rs369841797	273	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1274867520 CA412593578	276	K>R		No	ClinGen TOPMed
TCGA novel	278	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs963066713 CA327670720	279	N>K		No	ClinGen TOPMed
CA10370419 rs756209217	282	K>N		No	ClinGen ExAC gnomAD
rs764120865 COSM1467291 CA10370420 COSM1119392	286	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10370421 rs754349627	287	R>*		No	ClinGen ExAC gnomAD
rs374940902 CA10370422	287	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374940902 CA412593652	287	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442089915 CA412593658	288	S>C		No	ClinGen gnomAD
CA10370423 rs779465209	288	S>T		No	ClinGen ExAC gnomAD
CA10370424 rs200919353	289	K>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1464836975 CA412593688	291	A>T		No	ClinGen gnomAD
TCGA novel	291	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10370425 rs758763865	293	M>L		No	ClinGen ExAC gnomAD
CA412593757 rs1403179050	295	V>A		No	ClinGen gnomAD
rs1329415351 CA412593778	297	K>R		No	ClinGen gnomAD
TCGA novel	297	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779871743 CA10370426	298	M>I		No	ClinGen ExAC gnomAD
CA10370427 rs746616261	301	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	306	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	308	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768282664 CA10370428	312	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	313	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200387112 CA412594048	317	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200387112 CA10370437	317	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA327670750 rs145285684	318	G>C		No	ClinGen ESP TOPMed
CA412594058 rs1363345004	318	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	319	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760821521 CA10370439	321	G>S		No	ClinGen ExAC TOPMed gnomAD
CA412594110 rs1168743734	323	K>R		No	ClinGen gnomAD
CA412594124 rs1601973664	324	D>G		No	ClinGen Ensembl
rs764175819 CA10370440	324	D>H		No	ClinGen ExAC gnomAD
rs1281498422 CA412594147	326	Y>H		No	ClinGen gnomAD
rs368045553 CA10370442	330	S>P		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q96LI9

No regional properties for Q96LI9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96LI9

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MNRSSNVPRK	GILKSGTRSL	QKVRRVHFAN	ARNARSLLSM	LKDISAQIIQ	RAWLSHTNKM
70	80	90	100	110	120
IFRLLKHAIC	AAEFYVTHEI	LKKVAPLEAK	LIKDPTMQCK	IRFRFRGETF	PPFIVFKIFL
130	140	150	160	170	180
HTDGHGYKYF	SGKNVLMPSS	KAVDDACKLM	GERKFHRIIM	EDERIFPKSK	VTDIMDVVTM
190	200	210	220	230	240
QDYVQYRSFF	DEAPAFSGGR	NNSWRKLNLE	NIPRTMLMYD	IVHYSESGVI	SNRLRNEMKF
250	260	270	280	290	300
LLQRPVTQEI	HKHQLRIVSE	IRGPYLTVQP	LYRPYKQQNQ	VKFLGRRSKQ	AQMKVEKMRK
310	320	330
VYLAKEKNTS	EVTEPKTGPS	GTKDNYHLHS	IF