AiPD: Autoinhibited Protein Database

Q96IU2

Gene name	ZBED3
Protein name	Zinc finger BED domain-containing protein 3
Names	Axin-interacting protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84327
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

70-146 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

70-146 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96IU2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96IU2-F1	Predicted				AlphaFoldDB

212 variants for Q96IU2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA121424011 rs904312589	2	R>S		No	ClinGen TOPMed gnomAD
CA121424009 rs915246544	3	S>N		No	ClinGen TOPMed gnomAD
rs1229557200 CA360327364	5	E>K		No	ClinGen TOPMed
CA360327347 rs1265378384	6	P>Q		No	ClinGen gnomAD
CA360327338 rs1398040546	7	A>D		No	ClinGen TOPMed
rs752492611 CA3314741	9	T>A		No	ClinGen ExAC gnomAD
TCGA novel	9	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1041821286 CA121424004	10	M>T		No	ClinGen TOPMed gnomAD
rs956984173 CA360327283 CA121424000	11	D>E		No	ClinGen TOPMed
CA3314740 rs764954901	11	D>H		No	ClinGen ExAC gnomAD
rs945742135 CA121423996	12	Q>E		No	ClinGen TOPMed gnomAD
rs945742135 CA121423998	12	Q>K		No	ClinGen TOPMed gnomAD
CA360327258 rs1337492939	13	A>V		No	ClinGen gnomAD
CA360327254 rs1329520106	14	R>G		No	ClinGen TOPMed gnomAD
rs1343840583 CA360327251	14	R>H		No	ClinGen TOPMed
CA360327253 rs1329520106	14	R>S		No	ClinGen TOPMed gnomAD
rs759492668 CA3314739	15	G>R		No	ClinGen ExAC TOPMed gnomAD
CA360327227 rs1281460716	17	D>N		No	ClinGen TOPMed
CA121423992 rs911534498	19	A>P		No	ClinGen Ensembl
rs1178250657 CA360327162	20	A>V		No	ClinGen gnomAD
CA360327151 rs1470426154	21	A>E		No	ClinGen TOPMed gnomAD
rs1470426154 CA360327147	21	A>V		No	ClinGen TOPMed gnomAD
rs1424672007 CA360327137	22	R>L		No	ClinGen TOPMed gnomAD
CA360327139 rs1424672007	22	R>P		No	ClinGen TOPMed gnomAD
rs1424672007 CA360327141	22	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	22	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174551837 CA360327121	24	G>S		No	ClinGen TOPMed
CA360327110 rs1377521165	25	Q>*		No	ClinGen TOPMed
rs1417585318 CA360327105	25	Q>R		No	ClinGen TOPMed
CA360327092 rs1471227567	26	C>S		No	ClinGen TOPMed gnomAD
CA360327079 rs1383913560	27	P>Q		No	ClinGen TOPMed
rs987741438 CA121423989	28	G>R		No	ClinGen TOPMed
CA360327067 rs1277688715	28	G>V		No	ClinGen gnomAD
TCGA novel	30	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181801448 CA360327038	31	P>Q		No	ClinGen TOPMed gnomAD
rs1181801448 CA360327036	31	P>R		No	ClinGen TOPMed gnomAD
rs1351095754 CA360327018	33	P>A		No	ClinGen TOPMed
rs1486476503 CA360327007	34	T>A		No	ClinGen TOPMed
TCGA novel	37	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA121423980 rs965588295	37	P>L		No	ClinGen TOPMed gnomAD
rs181914313 CA3314736	38	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3314735 rs762005321	39	G>D		No	ClinGen ExAC gnomAD
TCGA novel	43	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374479650 CA360326899	44	P>S		No	ClinGen gnomAD
CA360326890 rs1455256601	45	Y>H		No	ClinGen TOPMed
CA3314734 rs774283853	46	S>A		No	ClinGen ExAC gnomAD
rs952348044 CA360326873	46	S>C		No	ClinGen TOPMed gnomAD
CA121423972 rs952348044	46	S>F		No	ClinGen TOPMed gnomAD
CA121423968 rs973602994	47	E>K		No	ClinGen TOPMed gnomAD
rs1352812467 CA360326855	48	A>T		No	ClinGen Ensembl
rs963840012 CA121423966	50	G>V		No	ClinGen Ensembl
rs1026640852 CA121423964	52	F>C		No	ClinGen TOPMed gnomAD
rs1239063624 CA360326773	53	H>Q		No	ClinGen TOPMed
CA360326755 rs1158064923	55	A>V		No	ClinGen TOPMed gnomAD
CA360326705 rs1468430853	60	G>R		No	ClinGen TOPMed
CA360326678 rs1214334889	61	H>Q		No	ClinGen TOPMed
CA360326656 rs1448310713	63	S>*		No	ClinGen gnomAD
CA360326608 rs566987172 CA3314732	66	W>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA360326620 rs1456608084	66	W>R		No	ClinGen TOPMed
rs1420609348 CA360326604	67	A>T		No	ClinGen TOPMed
rs1215204857 CA360326600	67	A>V		No	ClinGen gnomAD
rs544486879 CA121423955	68	T>P		No	ClinGen Ensembl
rs1162474070 CA360326578	69	C>R		No	ClinGen TOPMed
rs1246582133 CA360326561	70	R>C		No	ClinGen TOPMed gnomAD
CA360326562 rs1246582133	70	R>G		No	ClinGen TOPMed gnomAD
rs1345944526 CA360326517	74	E>A		No	ClinGen TOPMed gnomAD
CA3314730 rs749458270	74	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1345944526 CA360326515	74	E>V		No	ClinGen TOPMed gnomAD
rs1297693864 CA360326475	77	G>D		No	ClinGen TOPMed gnomAD
rs905713001 CA121423948	78	R>C		No	ClinGen TOPMed gnomAD
TCGA novel	78	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs546975061 CA121423946	79	G>S		No	ClinGen 1000Genomes gnomAD
rs1405289107 CA360326441	80	P>L		No	ClinGen gnomAD
CA360326446 rs1187138825	80	P>S		No	ClinGen TOPMed gnomAD
CA360326433 rs1316197020	81	G>D		No	ClinGen TOPMed
CA360326412 rs1203942840	83	H>D		No	ClinGen TOPMed
CA360326388 rs1412156294	84	A>V		No	ClinGen gnomAD
rs746201187 CA3314727	87	S>*		No	ClinGen ExAC TOPMed gnomAD
rs746201187 CA3314728	87	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1256617234 CA360326284	92	H>Y		No	ClinGen TOPMed
CA360326243 rs1223208497	95	S>N		No	ClinGen TOPMed gnomAD
rs1320982653 CA360326236	95	S>R		No	ClinGen gnomAD
rs1185145619 CA360326227	96	A>V		No	ClinGen TOPMed gnomAD
CA360326213 rs1287476679	97	H>Q		No	ClinGen TOPMed gnomAD
CA360326206 rs1216069043	98	R>Q		No	ClinGen gnomAD
CA360326209 rs1301453202	98	R>W		No	ClinGen TOPMed
rs781745383 CA3314726	99	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA360326199 rs1362947437	99	R>W		No	ClinGen gnomAD
rs1398353695 CA360326156	103	S>G		No	ClinGen gnomAD
CA360326135 rs1415914622	106	A>T		No	ClinGen TOPMed
TCGA novel	106	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1339139279 CA360326041	113	A>V		No	ClinGen TOPMed
rs1309471555 CA360325999	116	P>L		No	ClinGen TOPMed
CA360325997 rs1309471555	116	P>Q		No	ClinGen TOPMed
CA360325983 rs1279311355	117	P>L		No	ClinGen TOPMed
CA121423924 rs924160741	119	P>S		No	ClinGen TOPMed
rs977050633 CA121423922	120	G>S		No	ClinGen TOPMed gnomAD
CA121423916 rs965890540	121	P>H		No	ClinGen TOPMed gnomAD
rs1243436694 CA360325932	121	P>S		No	ClinGen TOPMed gnomAD
rs911403053 CA121423914	126	E>K		No	ClinGen TOPMed gnomAD
rs1430721372 CA360325890	127	G>S		No	ClinGen TOPMed
rs1348604631 CA360325878	129	W>R		No	ClinGen gnomAD
CA360325859 rs1214598709	131	R>H		No	ClinGen gnomAD
CA121423912 rs985167445	135	Q>*		No	ClinGen TOPMed
rs1190097266 CA360325810	135	Q>R		No	ClinGen TOPMed
CA360325771 rs1410922986	138	A>S		No	ClinGen gnomAD
TCGA novel	138	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs952501477 CA121423909	141	V>M		No	ClinGen TOPMed gnomAD
rs1270427314 CA360325722	142	R>C		No	ClinGen gnomAD
rs530122380 CA360325711	143	G>C		No	ClinGen 1000Genomes TOPMed
CA360325709 rs1191202738	143	G>D		No	ClinGen gnomAD
CA121423907 rs530122380	143	G>S		No	ClinGen 1000Genomes TOPMed
rs1356279707 CA360325695	144	S>N		No	ClinGen TOPMed gnomAD
rs1580145662 CA360325698	144	S>R		No	ClinGen Ensembl
rs1206511115 CA360325670	146	R>Q		No	ClinGen gnomAD
CA360325675 rs1244860051	146	R>W		No	ClinGen TOPMed gnomAD
CA360325651 rs1257189430	147	E>D		No	ClinGen gnomAD
rs1325861019 CA360325644	148	R>Q		No	ClinGen gnomAD
CA360325646 rs1217098356	148	R>W		No	ClinGen gnomAD
CA360325635 rs1284032590	149	E>A		No	ClinGen TOPMed gnomAD
CA360325626 rs1386231543	149	E>D		No	ClinGen gnomAD
CA360325632 rs1284032590	149	E>G		No	ClinGen TOPMed gnomAD
CA360325617 rs1365544592	150	L>P		No	ClinGen gnomAD
rs1365544592 CA360325615	150	L>R		No	ClinGen gnomAD
CA360325612 rs1395244951	151	E>K		No	ClinGen TOPMed
CA360325584 rs1444877126	152	R>L		No	ClinGen TOPMed gnomAD
rs1444877126 CA360325585	152	R>Q		No	ClinGen TOPMed gnomAD
rs1443557132 CA360325590	152	R>W		No	ClinGen gnomAD
rs1329655804 CA360325575	153	R>C		No	ClinGen gnomAD
CA360325562 rs1175906662	154	E>K		No	ClinGen TOPMed
CA3314723 rs2303713	155	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs2303714 CA3314724	155	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1422410152 CA360325523	157	V>M		No	ClinGen gnomAD
CA360325475 rs1196480586	159	Q>H		No	ClinGen gnomAD
CA360325490 rs1237360765	159	Q>K		No	ClinGen gnomAD
rs1035990533 CA360325461	160	G>C		No	ClinGen TOPMed gnomAD
rs1256859897 CA360325459	160	G>D		No	ClinGen TOPMed gnomAD
rs1035990533 CA121423899	160	G>R		No	ClinGen TOPMed gnomAD
CA360325448 rs1232764544	161	E>*		No	ClinGen gnomAD
rs1310584847 CA360325435	161	E>D		No	ClinGen gnomAD
rs1309218640 CA360325428	162	R>C		No	ClinGen gnomAD
CA360325424 rs1325316264	162	R>P		No	ClinGen TOPMed
CA360325407 rs1307572192	163	A>D		No	ClinGen TOPMed gnomAD
rs1376725093 CA360325417	163	A>T		No	ClinGen gnomAD
CA360325409 rs1307572192	163	A>V		No	ClinGen TOPMed gnomAD
rs1243496788 CA360325375	166	R>G		No	ClinGen gnomAD
CA360325371 rs1349751465	166	R>Q		No	ClinGen TOPMed
CA360325360 rs1234199523	167	R>K		No	ClinGen gnomAD
rs1286211143 CA360325348	168	R>W		No	ClinGen TOPMed
rs1002792929 CA121423897	172	Q>E		No	ClinGen TOPMed
rs1407273887 CA360325285	176	R>C		No	ClinGen gnomAD
CA360325287 rs1407273887	176	R>S		No	ClinGen gnomAD
rs1469532694 CA360325277	177	A>G		No	ClinGen TOPMed
CA360325280 rs1341204674	177	A>P		No	ClinGen Ensembl
CA360325273 rs1450536143	178	A>T		No	ClinGen gnomAD
CA360325270 rs1288423479	178	A>V		No	ClinGen TOPMed gnomAD
CA3314721 rs531117283	179	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA121423893 rs531117283	179	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA121423891 rs565365861	180	Q>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs1356991879 CA360325255	181	A>E		No	ClinGen gnomAD
CA360325253 rs1356991879	181	A>V		No	ClinGen gnomAD
CA360325247 rs1160586164	182	R>L		No	ClinGen gnomAD
CA121423889 rs545218118	183	R>W		No	ClinGen 1000Genomes TOPMed
CA360325212 rs1580145398	188	E>A		No	ClinGen Ensembl
rs1379554220 CA360325215	188	E>K		No	ClinGen TOPMed gnomAD
CA360325206 rs765047926	189	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1446262847 CA360325190	191	A>G		No	ClinGen TOPMed gnomAD
rs1446262847 CA360325189	191	A>V		No	ClinGen TOPMed gnomAD
rs1200150891 CA360325181	193	Q>*		No	ClinGen gnomAD
rs1482365114 CA360325172	194	A>E		No	ClinGen TOPMed gnomAD
CA360325168 rs1262572928	195	R>W		No	ClinGen TOPMed gnomAD
rs1336230119 CA360325149	198	D>V		No	ClinGen TOPMed
CA360325134 rs1271765589	200	S>R		No	ClinGen TOPMed
rs753609606 CA3314718	201	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1182964236 CA360325125	202	R>C		No	ClinGen TOPMed
CA360325123 rs1248767332	202	R>L		No	ClinGen gnomAD
CA360325118 rs1235028321	203	E>A		No	ClinGen TOPMed
rs766400104 CA3314717	205	A>T		No	ClinGen ExAC TOPMed gnomAD
CA360325099 rs1419238185	206	L>P		No	ClinGen TOPMed
CA360325092 rs1376441807	207	G>D		No	ClinGen TOPMed gnomAD
CA360325094 rs1376441807	207	G>V		No	ClinGen TOPMed gnomAD
CA360325083 rs1290153829	208	W>C		No	ClinGen TOPMed gnomAD
CA121423876 rs944339162	209	A>D		No	ClinGen TOPMed gnomAD
CA3314715 rs774498544	209	A>T		No	ClinGen ExAC gnomAD
rs763294757 CA3314714	210	P>A		No	ClinGen ExAC TOPMed gnomAD
CA360325075 rs1561297155	210	P>L		No	ClinGen Ensembl
rs763294757 CA3314713	210	P>S		No	ClinGen ExAC TOPMed gnomAD
rs75274568 CA3314709	213	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776853797 CA3314708	214	P>S		No	ClinGen ExAC gnomAD
CA360325047 rs1488027999	215	P>L		No	ClinGen gnomAD
rs1194630385 CA360325052	215	P>T		No	ClinGen gnomAD
rs747416575 CA360325033	217	K>N		No	ClinGen ExAC gnomAD
rs1244445943 CA360325027	218	D>V		No	ClinGen gnomAD
TCGA novel	219	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA360325012 rs1357602823	220	P>L		No	ClinGen gnomAD
CA3314704 rs370739839	221	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA121423858 rs868441142	222	G>D		No	ClinGen Ensembl
CA121423856 rs868441142	222	G>V		No	ClinGen Ensembl
CA360324999 rs747628565	223	D>N		No	ClinGen ExAC TOPMed
rs747628565 CA3314702	223	D>Y		No	ClinGen ExAC TOPMed
rs778587173 CA3314701	224	R>M		No	ClinGen ExAC gnomAD
rs1279738019 CA360324988	224	R>S		No	ClinGen gnomAD
rs778587173 CA360324989	224	R>T		No	ClinGen ExAC gnomAD
rs1373898812 CA360324977	226	G>R		No	ClinGen TOPMed
CA360324978 rs1373898812	226	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA360324973 rs1214989019	226	G>V		No	ClinGen gnomAD
CA360324968 rs1580145200	227	C>S		No	ClinGen Ensembl
rs1388449812 CA360324955	229	I>T		No	ClinGen TOPMed gnomAD
CA360324957 rs1295745219	229	I>V		No	ClinGen gnomAD
rs1391314698 CA360324944	231	K>E		No	ClinGen gnomAD
rs1456244447 CA360324927	233	L>P		No	ClinGen gnomAD
rs1171743793 CA360324914	235	L>Y		No	ClinGen TOPMed gnomAD

No associated diseases with Q96IU2

1 regional properties for Q96IU2

Type	Name	Position	InterPro Accession
domain	Zinc finger, BED-type	43 - 104	IPR003656

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
transcription cis-regulatory region binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

13 GO annotations of biological process

Name	Definition
actin filament organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
endoplasmic reticulum localization	Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.
establishment of spindle localization	The directed movement of the spindle to a specific location in the cell.
mitochondrion localization	Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
negative regulation of protein phosphorylation	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
positive regulation of canonical Wnt signaling pathway	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of embryonic development	Any process that activates or increases the frequency, rate or extent of embryonic development.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to glucose	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
response to insulin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MRSGEPACTM	DQARGLDDAA	ARGGQCPGLG	PAPTPTPPGR	LGAPYSEAWG	YFHLAPGRPG
70	80	90	100	110	120
HPSGHWATCR	LCGEQVGRGP	GFHAGTSALW	RHLRSAHRRE	LESSGAGSSP	PAAPCPPPPG
130	140	150	160	170	180
PAAAPEGDWA	RLLEQMGALA	VRGSRREREL	ERRELAVEQG	ERALERRRRA	LQEEERAAAQ
190	200	210	220	230
ARRELQAERE	ALQARLRDVS	RREGALGWAP	AAPPPLKDDP	EGDRDGCVIT	KVLL