AiPD: Autoinhibited Protein Database

Q96H35

Gene name	RBM18
Protein name	Probable RNA-binding protein 18
Names	RNA-binding motif protein 18
Species	Homo sapiens (Human)
KEGG Pathway	hsa:92400
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-190 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

78-190 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96H35

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96H35-F1	Predicted				AlphaFoldDB

135 variants for Q96H35

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1208801530 CA374780307	3	A>T		No	ClinGen gnomAD
CA5224301 rs755712347	4	E>D		No	ClinGen ExAC gnomAD
CA374780274 COSM1314421 rs1238898726	5	T>I	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5224300 rs752115212	5	T>S		No	ClinGen ExAC gnomAD
CA374780252 rs1204689356	8	L>P		No	ClinGen TOPMed
rs767203964 CA5224299	9	P>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	10	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1212029552 CA374780222	13	A>T		No	ClinGen TOPMed
TCGA novel	13	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5224297 rs142072362	14	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1321548081 CA374780209	15	I>N		No	ClinGen gnomAD
rs1382294354 CA374780211	15	I>V		No	ClinGen gnomAD
CA374780202 rs1437554916	16	L>P		No	ClinGen gnomAD
CA374780177 rs1200664345	20	S>A		No	ClinGen TOPMed
TCGA novel	20	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5224295 rs762727807	22	Q>E		No	ClinGen ExAC gnomAD
rs189718399 CA5224294	23	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1384379486 CA374780145	25	H>P		No	ClinGen gnomAD
rs1188730969 CA374780139	26	R>*		No	ClinGen gnomAD
rs1440546987 CA374780137	26	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374780123 rs1158687506	28	W>L		No	ClinGen TOPMed
CA374780118 rs1259007140	29	I>V		No	ClinGen gnomAD
CA374780095 rs1204077231	32	L>P		No	ClinGen gnomAD
rs1413504860 CA374780093	33	D>Y		No	ClinGen TOPMed
CA374780060 rs1294663772	37	T>I		No	ClinGen gnomAD
CA374780058 rs1394677995	38	E>K		No	ClinGen TOPMed
CA374779384 rs1337675173	40	H>Y		No	ClinGen gnomAD
CA374779361 rs762847246	42	L>F		No	ClinGen ExAC gnomAD
CA5224277 rs762847246	42	L>I		No	ClinGen ExAC gnomAD
CA5224276 rs201291648	46	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs760666889 CA199446915	51	V>I		No	ClinGen Ensembl
CA199446878 rs376059542	59	H>Y		No	ClinGen ESP TOPMed gnomAD
rs377109202 CA199446871	63	A>V		No	ClinGen gnomAD
COSM1104818 rs1430729865 CA374779049	69	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1173679427 CA374779047	69	R>Q		No	ClinGen gnomAD
rs1387944736 CA374778994	73	F>L		No	ClinGen TOPMed
CA5224273 rs776776524	73	F>S		No	ClinGen ExAC TOPMed gnomAD
rs750099497 CA5224272	75	N>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	79	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374778312 rs1246510737	82	A>G		No	ClinGen gnomAD
CA5224251 rs759635110	82	A>T		No	ClinGen ExAC gnomAD
rs1312371590 CA374778226	87	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374778214 rs1449344732	87	Q>H		No	ClinGen gnomAD
CA199443961 rs867091740	87	Q>R		No	ClinGen Ensembl
CA374778198 rs1451476550	88	C>*		No	ClinGen gnomAD
CA374778168 rs1247857571	90	N>S		No	ClinGen gnomAD
rs774794967 CA374778145	91	G>A		No	ClinGen ExAC gnomAD
CA5224250 rs774794967	91	G>D		No	ClinGen ExAC gnomAD
CA199443949 rs866235851	94	A>V		No	ClinGen Ensembl
rs1384935250 CA374778064	97	K>E		No	ClinGen gnomAD
rs934094626 CA199443903	97	K>R		No	ClinGen Ensembl
rs771261518 CA5224247	98	K>R		No	ClinGen ExAC gnomAD
CA374777989 rs1450299362	101	V>A		No	ClinGen gnomAD
CA5224246 rs749662781	102	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA5224245 rs778296954	103	W>R		No	ClinGen ExAC gnomAD
rs770263708 CA5224244	105	H>D		No	ClinGen ExAC gnomAD
rs1183161411 CA374777931	105	H>R		No	ClinGen gnomAD
rs746545524 CA5224242	107	Q>E		No	ClinGen ExAC gnomAD
rs376023850 CA5224241	107	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5224240 rs376023850	107	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5224239 rs749984013	109	K>R		No	ClinGen ExAC gnomAD
rs149650476 CA5224221	110	R>K		No	ClinGen ESP ExAC TOPMed
rs996001734 CA199442061	111	Y>D		No	ClinGen TOPMed
CA5224220 rs756907995	112	D>G		No	ClinGen ExAC gnomAD
CA374777543 rs756907995	112	D>V		No	ClinGen ExAC gnomAD
rs749114687 CA5224219	113	H>R		No	ClinGen ExAC TOPMed gnomAD
CA374777483 rs1212445260	114	N>K		No	ClinGen gnomAD
rs1564454940 CA374777497	114	N>S		No	ClinGen Ensembl
CA199442049 rs373830841	116	N>H		No	ClinGen Ensembl
CA199442028 rs1041132462	117	D>V		No	ClinGen TOPMed
CA374777379 rs1434847020	119	I>L		No	ClinGen gnomAD
CA199442019 rs1040128695	119	I>M		No	ClinGen TOPMed
rs901716143 CA199442027	119	I>S		No	ClinGen gnomAD
rs376963049 CA5224217	121	P>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA5224218 rs777668021	121	P>S		No	ClinGen ExAC gnomAD
CA5224216 rs200837960	122	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5224215 rs767489161	123	S>G		No	ClinGen ExAC gnomAD
CA374777281 rs1420913993	124	L>F		No	ClinGen Ensembl
rs766532373 CA5224212	125	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1409629978 CA374777236	126	P>S		No	ClinGen gnomAD
CA5224210 rs773573134	130	T>P		No	ClinGen ExAC gnomAD
CA374777073 rs1266756786	132	P>R		No	ClinGen gnomAD
rs1480797498 CA374777022	135	S>P		No	ClinGen gnomAD
rs1234407611 CA374777018	135	S>Y		No	ClinGen TOPMed gnomAD
rs1184393931 CA374777005	136	N>H		No	ClinGen TOPMed
rs1201947496 CA374776963	137	L>P		No	ClinGen gnomAD
CA374776947 rs1436897946	138	S>N		No	ClinGen gnomAD
rs1459538886 CA374776674	140	T>A		No	ClinGen gnomAD
CA5224192 rs758636046	143	I>L		No	ClinGen ExAC TOPMed gnomAD
CA374776654 rs758636046	143	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5224191 rs750700240	145	A>S		No	ClinGen ExAC gnomAD
rs1223633773 CA374776632	146	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374776616 rs1383790951	148	A>G		No	ClinGen gnomAD
rs1405378196 CA374776580	153	M>I		No	ClinGen gnomAD
CA5224188 rs777026900	153	M>K		No	ClinGen ExAC gnomAD
rs1289555831 CA374776575	154	A>S		No	ClinGen TOPMed gnomAD
rs1289555831 CA374776577	154	A>T		No	ClinGen TOPMed gnomAD
rs764531100 CA5224187	154	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	155	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374776568 rs1156654041	155	E>G		No	ClinGen gnomAD
rs1438930009 CA374776552	157	P>L		No	ClinGen gnomAD
CA374776544 rs1442424958	158	D>E		No	ClinGen gnomAD
CA374776549 rs1184995164	158	D>H		No	ClinGen gnomAD
rs1254826324 CA374776526	161	Y>D		No	ClinGen gnomAD
rs1254826324 CA374776527	161	Y>H		No	ClinGen gnomAD
rs1186644748 CA374776515	162	P>L		No	ClinGen gnomAD
rs150794673 CA5224183	163	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374776504 rs1259551925	164	A>V		No	ClinGen TOPMed gnomAD
CA374776501 rs1360542658	165	P>S		No	ClinGen gnomAD
rs1294430190 CA374776496	166	V>I		No	ClinGen gnomAD
rs1382360935 CA374776478	168	S>F		No	ClinGen gnomAD
CA199439363 rs202121880	169	Y>*		No	ClinGen Ensembl
CA5224180 rs747917276	169	Y>C		No	ClinGen ExAC gnomAD
CA199439341 rs746663334	170	F>L		No	ClinGen TOPMed gnomAD
rs111532590 CA199439351	170	F>S		No	ClinGen Ensembl
CA5224179 rs781003949	171	K>Q		No	ClinGen ExAC gnomAD
CA374776454 rs1419039064	172	P>Q		No	ClinGen gnomAD
CA374776458 rs1286982427	172	P>T		No	ClinGen gnomAD
rs1165279730 CA374776450	173	P>Q		No	ClinGen gnomAD
CA5224178 rs768485810	173	P>S		No	ClinGen ExAC gnomAD
CA374776452 rs768485810	173	P>T		No	ClinGen ExAC gnomAD
CA374776441 rs1367587940	174	D>E		No	ClinGen gnomAD
rs1422332046 CA374776447	174	D>N		No	ClinGen gnomAD
rs746909067 CA5224177	175	K>R		No	ClinGen ExAC gnomAD
rs1429704012 CA374776395	181	Y>C		No	ClinGen gnomAD
rs779955411 CA5224176	183	R>T		No	ClinGen ExAC gnomAD
CA374776377 rs1564453940	184	T>A		No	ClinGen Ensembl
CA5224175 rs372681152	184	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5224173 rs779151852	187	K>T		No	ClinGen ExAC gnomAD
rs757422073 CA5224172	188	S>C		No	ClinGen ExAC gnomAD
CA5224171 rs754184979	189	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146365190 CA5224170	189	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5224168 rs184989286	190	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1399283977 CA374776337	191	R>R		No	ClinGen gnomAD
CA374776335 rs762602502	191	R>S		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q96H35

2 regional properties for Q96H35

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	25 - 106	IPR000504
domain	RNA-binding protein 18, RNA recognition motif	26 - 105	IPR039157

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3ZCC5	RBM18	Probable RNA-binding protein 18	Bos taurus (Bovine)	PR
A0AV96	RBM47	RNA-binding protein 47	Homo sapiens (Human)	PR
Q8TBY0	RBM46	Probable RNA-binding protein 46	Homo sapiens (Human)	PR
Q9CR83	Rbm18	Probable RNA-binding protein 18	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEAETKTLPL	ENASILSEGS	LQEGHRLWIG	NLDPKITEYH	LLKLLQKFGK	VKQFDFLFHK
70	80	90	100	110	120
SGALEGQPRG	YCFVNFETKQ	EAEQAIQCLN	GKLALSKKLV	VRWAHAQVKR	YDHNKNDKIL
130	140	150	160	170	180
PISLEPSSST	EPTQSNLSVT	AKIKAIEAKL	KMMAENPDAE	YPAAPVYSYF	KPPDKKRTTP

YSRTAWKSRR