AiPD: Autoinhibited Protein Database

Q96GY3

Gene name	LIN37 (MSTP064)
Protein name	Protein lin-37 homolog
Names	Antolefinin
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55957
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-216 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

101-216 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q96GY3

Entry ID	Method	Resolution	Chain	Position	Source
7N40	X-ray	255 A	C	92-130	PDB
7R1D	EM	350 A	B	1-246	PDB
AF-Q96GY3-F1	Predicted				AlphaFoldDB

212 variants for Q96GY3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA405464321 rs764344868	5	K>N		No	ClinGen ExAC TOPMed gnomAD
CA9387102 rs751636541	6	V>E		No	ClinGen ExAC
CA9387103 rs757343727	10	K>I		No	ClinGen ExAC TOPMed gnomAD
CA9387104 rs757343727	10	K>T		No	ClinGen ExAC TOPMed gnomAD
CA9387124 rs767651009	13	L>V		No	ClinGen ExAC gnomAD
rs1599736570 CA405464490	14	E>Q		No	ClinGen Ensembl
rs1027877971 CA307814718	15	M>I		No	ClinGen Ensembl
rs1348237650 CA405464499	15	M>L		No	ClinGen Ensembl
rs1163284434 CA405464502	15	M>T		No	ClinGen gnomAD
CA405464507 rs170758	16	A>D		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs796989672 CA307814725	16	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs170758 VAR_061674 CA307814733	16	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC dbSNP gnomAD
rs756723431 CA405464520	18	A>D		No	ClinGen ExAC gnomAD
CA9387126 rs756723431	18	A>G		No	ClinGen ExAC gnomAD
rs913798209 CA307814738	19	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs766965615 CA9387127	19	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9387129 rs201196330	23	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1291896412 CA405464574	27	Q>*		No	ClinGen gnomAD
rs200797120 CA9387132	27	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9387131 rs747842588	27	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA9387133 rs530617326	31	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746490365 CA9387134	32	K>R		No	ClinGen ExAC gnomAD
CA307814764 rs1019128813	34	H>P		No	ClinGen gnomAD
CA9387136 rs768495288	35	M>I		No	ClinGen ExAC TOPMed gnomAD
rs552333590 CA9387137	36	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9387138 rs552333590	36	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405464641 rs775087716	37	R>K		No	ClinGen ExAC TOPMed gnomAD
CA9387139 rs775087716	37	R>M		No	ClinGen ExAC TOPMed gnomAD
CA405464642 rs775087716	37	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1416847106 CA405464657	38	E>K		No	ClinGen TOPMed gnomAD
rs369644711 CA9387156	39	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA9387157 rs374032128	39	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	41	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405464684 rs1220591594	42	E>*		No	ClinGen gnomAD
rs772392149 CA9387159	46	K>E		No	ClinGen ExAC gnomAD
rs937593176 CA307814993	47	T>I		No	ClinGen Ensembl
CA9387160 rs773555458	48	P>L		No	ClinGen ExAC gnomAD
CA405464724 rs1599736781	48	P>S		No	ClinGen Ensembl
rs760905984 CA9387161	49	S>L		No	ClinGen ExAC TOPMed gnomAD
rs771141743 CA9387162	51	T>N		No	ClinGen ExAC gnomAD
CA405464810 rs1331459394	55	D>N		No	ClinGen TOPMed
rs775852779 CA9387183	58	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9387182 rs770389464	58	I>V		No	ClinGen ExAC gnomAD
rs755361259 CA9387186	59	A>T		No	ClinGen ExAC TOPMed gnomAD
CA405464864 rs1388539586	59	A>V		No	ClinGen gnomAD
CA405464902 rs1339381938	64	R>G		No	ClinGen gnomAD
CA307815442 rs1033287559	68	R>C		No	ClinGen TOPMed gnomAD
rs200474658 CA9387198	68	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9387200 rs746027206	69	F>L		No	ClinGen ExAC gnomAD
CA9387199 rs781257135	69	F>Y		No	ClinGen ExAC gnomAD
rs991799359 CA307815462	70	P>A		No	ClinGen Ensembl
CA9387201 rs769764210	71	H>N		No	ClinGen ExAC TOPMed gnomAD
rs1288376443 CA405464988	71	H>R		No	ClinGen gnomAD
rs775578498 CA9387202	72	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA405464994 rs1309307099	72	Q>K		No	ClinGen TOPMed
CA405465009 rs1599737159	73	R>Q		No	ClinGen Ensembl
rs1199884175 CA405465007	73	R>W		No	ClinGen TOPMed gnomAD
CA405465056 rs1254175311	77	R>M		No	ClinGen gnomAD
TCGA novel	80	M>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs545882957 CA9387203	80	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1188149943 CA405465096	81	D>N		No	ClinGen gnomAD
CA405465121 rs1379670338	83	G>R		No	ClinGen TOPMed gnomAD
rs769110063 CA9387204	87	G>R		No	ClinGen ExAC gnomAD
CA405465172 rs1465249970	88	G>E		No	ClinGen gnomAD
CA405465170 rs1360717783	88	G>R		No	ClinGen gnomAD
rs774739431 CA9387205	89	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	91	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1396151979 CA405465201	91	R>Q		No	ClinGen gnomAD
rs1204023024 CA405465259	94	T>R		No	ClinGen Ensembl
CA405465267 rs1229344084	95	Y>*		No	ClinGen TOPMed
TCGA novel	96	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA307815585 rs1004672705	101	D>E		No	ClinGen TOPMed
rs370575872 CA405465324	101	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9387216 rs370575872	101	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA9387217 rs567934409	102	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1224150015 CA405465341	103	S>C		No	ClinGen gnomAD
rs902054109 CA307815591	103	S>I		No	ClinGen Ensembl
rs373853183 CA9387219	103	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA405465349 rs1315920074 COSM3198708	104	V>M	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1200455656 CA405465361	105	D>Y		No	ClinGen gnomAD
rs749336766 CA405465379 CA9387220	106	L>F		No	ClinGen ExAC gnomAD
rs1226191339 CA405465384	107	A>P		No	ClinGen gnomAD
rs1488024385 CA405465390	107	A>V		No	ClinGen gnomAD
rs1189275522 CA405465423	110	S>N		No	ClinGen gnomAD
rs367706790 CA9387222	110	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9387224 rs772332523	111	E>G		No	ClinGen ExAC gnomAD
CA9387223 rs748579282	111	E>K		No	ClinGen ExAC gnomAD
rs773570913 CA9387225	112	N>K		No	ClinGen ExAC TOPMed gnomAD
rs760270852 CA9387226	113	T>M		No	ClinGen ExAC gnomAD
rs776327934 CA9387228	114	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1292175813 CA405465488	117	P>A		No	ClinGen gnomAD
rs1292175813 CA405465489	117	P>S		No	ClinGen gnomAD
rs1405791774 CA405465512	119	C>Y		No	ClinGen gnomAD
rs1277863212 CA405465521	120	R>C		No	ClinGen TOPMed gnomAD
rs765329144 CA9387230	120	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1277863212 CA405465520	120	R>S		No	ClinGen TOPMed gnomAD
CA9387232 rs762926010	121	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9387233 rs762926010	121	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780422741 CA307815692	123	M>I		No	ClinGen gnomAD
CA9387235 rs376762591	124	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs368622689 CA9387236	124	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs753978779 CA9387237	125	N>T		No	ClinGen ExAC gnomAD
rs372661681 CA9387238	127	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA405465603 rs1478503569	127	P>L		No	ClinGen gnomAD
CA405465597 rs372661681	127	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1599737378 CA405465612	128	S>F		No	ClinGen Ensembl
rs778897894 CA9387239	129	V>L		No	ClinGen ExAC TOPMed gnomAD
rs865895826 CA307815712	130	R>C		No	ClinGen TOPMed gnomAD
CA9387241 rs201290153 COSM1195060	130	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA405465636 rs1297801244	131	E>G		No	ClinGen gnomAD
rs550629242 CA307815724	131	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA9387242 rs778033607	132	R>C		No	ClinGen ExAC TOPMed gnomAD
rs199605769 CA9387244	132	R>H		No	ClinGen ExAC TOPMed gnomAD
rs199605769 CA9387245	132	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9387243 rs778033607	132	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1259117802 CA405465676	135	S>C		No	ClinGen Ensembl
CA307815736 rs796089363	136	P>T		No	ClinGen gnomAD
rs1270853130 CA405465697	137	S>R		No	ClinGen gnomAD
CA405465704 rs1378278044	138	S>A		No	ClinGen gnomAD
CA307815739 rs569205978	139	P>T		No	ClinGen 1000Genomes gnomAD
rs769861276 CA307815768	142	P>L		No	ClinGen TOPMed gnomAD
CA307815759 rs769861276	142	P>Q		No	ClinGen TOPMed gnomAD
CA9387247 rs769442767	142	P>S		No	ClinGen ExAC gnomAD
rs566447622 CA307815770	143	L>M		No	ClinGen TOPMed gnomAD
rs972713262 CA307815779	144	P>L		No	ClinGen TOPMed
rs1215797252 CA405465773	146	D>A		No	ClinGen gnomAD
rs1442706692 CA405465924	151	E>D		No	ClinGen gnomAD
CA9387264 rs781639375	152	V>I		No	ClinGen ExAC gnomAD
rs745537884 CA9387265	153	T>A		No	ClinGen ExAC gnomAD
CA9387266 rs769530810	158	R>C		No	ClinGen ExAC TOPMed gnomAD
rs369546658 CA9387267	158	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs369546658 CA9387268	158	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA405465973 rs1352255729	159	D>Y		No	ClinGen TOPMed
CA9387269 rs200329090	160	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1377666079 CA405465992	162	K>Q		No	ClinGen TOPMed
CA405466000 rs1198567439	163	L>M		No	ClinGen TOPMed gnomAD
rs1361108262 CA405466010	164	P>L		No	ClinGen TOPMed
TCGA novel	165	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405466021 rs1246304025	166	P>L		No	ClinGen gnomAD
CA9387272 rs767314398	166	P>T		No	ClinGen ExAC gnomAD
CA9387273 rs772947202	168	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA405466029 rs772947202	168	P>T		No	ClinGen ExAC TOPMed gnomAD
CA307816224 rs1030391019	169	P>L		No	ClinGen gnomAD
rs1160534364 CA405466049	171	P>L		No	ClinGen TOPMed gnomAD
rs1160534364 CA405466047	171	P>Q		No	ClinGen TOPMed gnomAD
CA405466054 rs1398579139	172	P>R		No	ClinGen TOPMed gnomAD
CA9387275 VAR_051093 rs35617825	172	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758497685 CA9387277	173	G>R		No	ClinGen ExAC TOPMed gnomAD
rs764009561 CA9387278	175	A>V		No	ClinGen ExAC gnomAD
rs1406381139 CA405466073	176	C>S		No	ClinGen gnomAD
CA405466076 rs1555739874	176	C>Y		No	ClinGen Ensembl
rs1339240221 CA405466094	179	R>C		No	ClinGen gnomAD
rs752115972 CA9387279	179	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9387281 rs781713095	180	I>S		No	ClinGen ExAC gnomAD
rs757656466 CA9387280	180	I>V		No	ClinGen ExAC gnomAD
CA9387282 rs746202980	181	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9387283 rs372693905	184	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	185	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1036204464 CA307816268	186	P>S		No	ClinGen TOPMed
rs191191959 CA9387284	188	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA307816272 rs899084382	189	Q>K		No	ClinGen TOPMed
CA9387285 rs748817066	191	T>N		No	ClinGen ExAC gnomAD
rs1191642712 CA405466177	192	P>L		No	ClinGen gnomAD
rs375649208 CA9387288	194	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9387289 rs771960307	195	E>D		No	ClinGen ExAC gnomAD
CA9387308 rs778520598	196	P>S		No	ClinGen ExAC gnomAD
TCGA novel	198	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747584367 CA9387309	198	E>Q		No	ClinGen ExAC gnomAD
CA405466233 rs1263518842	199	P>H		No	ClinGen TOPMed
rs777680623 CA9387311	200	E>*		No	ClinGen ExAC TOPMed gnomAD
CA9387313 rs770721599	200	E>A		No	ClinGen ExAC TOPMed gnomAD
rs777680623 CA9387312 COSM1524692	200	E>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs774537515 CA9387317	202	S>*		No	ClinGen ExAC TOPMed gnomAD
CA9387316 rs768729158	202	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1262759173 CA405466262	204	S>F		No	ClinGen gnomAD
rs1237152796 CA633060341	204	S>Y		No	ClinGen gnomAD
CA405466268 rs1199965749	205	T>I		No	ClinGen gnomAD
CA405466265 rs1351468047	205	T>S		No	ClinGen gnomAD
rs1280410199 CA405466279	207	I>T		No	ClinGen TOPMed
CA9387320 rs750971522	208	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9387319 rs768206871	208	Y>D		No	ClinGen ExAC gnomAD
rs551356942 CA307816434	209	R>C		No	ClinGen 1000Genomes
rs551356942 CA307816427	209	R>G		No	ClinGen 1000Genomes
rs199515554 CA9387321	209	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199515554 CA405466289	209	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9387322 rs766790190	210	N>S		No	ClinGen ExAC gnomAD
CA405466304 rs1364062334	211	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA405466302 rs1160798464	211	M>T		No	ClinGen gnomAD
rs755744133 CA9387323	213	R>H		No	ClinGen ExAC TOPMed gnomAD
CA307816454 rs780801656	216	R>C		No	ClinGen gnomAD
rs754704937 CA9387324	216	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM566178 rs754704937 CA9387325	216	R>P	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs757905028 CA9387327	218	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9387328 rs777204895	218	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	221	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766769197 CA9387339	222	K>R		No	ClinGen ExAC gnomAD
CA9387341 rs182129539	227	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1460751330 CA405466460	227	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs752357586 CA9387343	228	N>K		No	ClinGen ExAC gnomAD
CA405466483 rs1281688798	229	Q>*		No	ClinGen gnomAD
CA405466493 rs1347435395	229	Q>H		No	ClinGen gnomAD
rs556772764 COSM3422693 CA9387344	231	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9387345 rs763621662	231	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757268176 CA9387347	233	S>L		No	ClinGen ExAC TOPMed gnomAD
rs745741550 CA9387349	235	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1373083590 CA405466581	236	M>T		No	ClinGen TOPMed
TCGA novel	237	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754903532 CA9387352 COSM1494304	240	R>Q	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA405466678 rs1427271230	244	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200650723 CA9387354	245	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1355475206 COSM187990 CA405466695	245	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA405466704 rs1457754420	246	Q>E		No	ClinGen gnomAD

No associated diseases with Q96GY3

No regional properties for Q96GY3

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96GY3

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
Myb complex	A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
transcription repressor complex	A protein complex that possesses activity that prevents or downregulates transcription.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MFPVKVKVEK	SELEMAKARN	QLDAVLQCLL	EKSHMDRERL	DEEAGKTPSD	THNKDCSIAA
70	80	90	100	110	120
TGKRPSARFP	HQRRKKRREM	DDGLAEGGPQ	RSNTYVIKLF	DRSVDLAQFS	ENTPLYPICR
130	140	150	160	170	180
AWMRNSPSVR	ERECSPSSPL	PPLPEDEEGS	EVTNSKSRDV	YKLPPPTPPG	PPGDACRSRI
190	200	210	220	230	240
PSPLQPEMQG	TPDDEPSEPE	PSPSTLIYRN	MQRWKRIRQR	WKEASHRNQL	RYSESMKILR

EMYERQ