AiPD: Autoinhibited Protein Database

Q96GN5

Gene name	CDCA7L (HR1, JPO2, R1)
Protein name	Cell division cycle-associated 7-like protein
Names	Protein JPO2, Transcription factor RAM2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55536
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

84-155 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

84-155 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q96GN5

Entry ID	Method	Resolution	Chain	Position	Source
5YI9	NMR	-	A	56-91	PDB
6EMO	NMR	-	A	1-32	PDB
AF-Q96GN5-F1	Predicted				AlphaFoldDB

452 variants for Q96GN5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA366962554 rs1409482952	4	A>E		No	ClinGen TOPMed gnomAD
CA366962551 rs1409482952	4	A>V		No	ClinGen TOPMed gnomAD
CA4184147 rs746210469	5	T>A		No	ClinGen ExAC TOPMed gnomAD
rs781561939 CA4184146	5	T>I		No	ClinGen ExAC gnomAD
rs771431727 CA4184145	6	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747480102 CA4184144	6	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4184143 rs777855441	7	Y>C		No	ClinGen ExAC gnomAD
rs1472190727 CA366962517	8	Q>*		No	ClinGen TOPMed
CA366961252 rs1370610908	10	P>S		No	ClinGen TOPMed
CA366961243 rs1230005482	11	K>E		No	ClinGen gnomAD
rs772671986 CA4184123	12	E>D		No	ClinGen ExAC gnomAD
rs1296380723 CA366961215	13	V>L		No	ClinGen gnomAD
CA4184122 rs748214238	14	A>P		No	ClinGen ExAC gnomAD
rs1345517473 CA366961161	18	N>S		No	ClinGen gnomAD
rs749525504 CA4184119 COSM1450000	19	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4184117 rs756998843	22	D>G		No	ClinGen ExAC gnomAD
rs899524730 CA155133132	22	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA366961109 rs1431671844	23	D>N		No	ClinGen gnomAD
CA366961096 rs1360762453	24	E>A		No	ClinGen TOPMed gnomAD
rs1054194530 CA155133128	24	E>D		No	ClinGen gnomAD
CA366961083 rs1192727640	25	E>A		No	ClinGen gnomAD
CA366961076 rs1434048979	26	F>I		No	ClinGen gnomAD
TCGA novel	27	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366961029 rs1276420267	30	R>*		No	ClinGen TOPMed
CA366961026 rs1269833920	30	R>Q		No	ClinGen gnomAD
rs751412582 CA4184116	31	D>N		No	ClinGen ExAC gnomAD
rs1337324374 CA366961008	32	D>N		No	ClinGen TOPMed
CA155133126 rs750872071	32	D>V		No	ClinGen Ensembl
CA4184114 rs144827468	34	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	35	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764733775 CA366960981	35	M>R		No	ClinGen ExAC gnomAD
rs764733775 CA4184111	35	M>T		No	ClinGen ExAC gnomAD
rs752165445 CA4184112	35	M>V		No	ClinGen ExAC gnomAD
CA4184110 rs759134896	36	E>K		No	ClinGen ExAC gnomAD
rs776257349 CA4184109	37	T>N		No	ClinGen ExAC gnomAD
rs766117501 CA4184108	38	L>F		No	ClinGen ExAC TOPMed gnomAD
CA366960964 rs766117501	38	L>V		No	ClinGen ExAC TOPMed gnomAD
rs760913603 CA4184107	39	S>A		No	ClinGen ExAC
CA4184106 rs768051788	39	S>L		No	ClinGen ExAC TOPMed gnomAD
CA366960951 rs1407981551	40	S>L		No	ClinGen gnomAD
rs1368782024 CA366960940	42	E>*		No	ClinGen gnomAD
rs370547386 CA155133005	42	E>D		No	ClinGen ESP TOPMed
CA4184103 rs367734480	43	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs200312608 CA4184102	43	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1379611223 CA366960927	44	C>G		No	ClinGen gnomAD
rs140187169 CA4184099	45	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA155132950 VAR_083475 rs937337760	45	D>N		No	ClinGen UniProt TOPMed dbSNP
CA366960911 rs746734289	46	S>N		No	ClinGen ExAC TOPMed gnomAD
CA4184098 rs746734289	46	S>T		No	ClinGen ExAC TOPMed gnomAD
CA4184097 rs777657303	50	L>V		No	ClinGen ExAC gnomAD
CA366960876 rs1200553972	51	E>D		No	ClinGen gnomAD
rs752647964 CA4184095	53	G>R		No	ClinGen ExAC gnomAD
CA366960834 rs1322916643	56	Q>K		No	ClinGen gnomAD
CA4184073 rs779644053	57	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1562624859 CA366960823	57	D>V		No	ClinGen Ensembl
CA366960826 rs779644053	57	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA4184072 rs146108005	59	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776664746 CA4184071	59	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4184070 rs767335629	61	H>R		No	ClinGen ExAC TOPMed gnomAD
rs200336698 CA4184069	62	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764648693 CA4184067	63	K>R		No	ClinGen ExAC gnomAD
rs764648693 CA4184068	63	K>T		No	ClinGen ExAC gnomAD
TCGA novel	67	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775368336 CA4184065	68	E>D		No	ClinGen ExAC gnomAD
CA366960752 rs1446192361	68	E>G		No	ClinGen gnomAD
rs551496318 CA4184066	68	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA4184064 rs769933500	73	F>L		No	ClinGen ExAC gnomAD
CA366960707 rs1337631936	75	E>Q		No	ClinGen TOPMed
TCGA novel	76	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759596331 CA4184063	76	D>N		No	ClinGen ExAC gnomAD
CA366960689 rs776912112	77	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4184062 rs776912112	77	T>S		No	ClinGen ExAC gnomAD
CA4184061 rs747912377	78	D>A		No	ClinGen ExAC gnomAD
CA4184059 rs778699445	78	D>E		No	ClinGen ExAC TOPMed gnomAD
CA4184060 rs747912377	78	D>V		No	ClinGen ExAC gnomAD
CA4184058 rs768537964	80	E>D		No	ClinGen ExAC TOPMed gnomAD
rs11554264 CA155128920	80	E>Q		No	ClinGen Ensembl
rs749251554 CA4184057	83	D>N		No	ClinGen ExAC TOPMed gnomAD
rs755636513 CA4184054	90	S>G		No	ClinGen ExAC gnomAD
CA155128908 rs996618842	92	L>V		No	ClinGen Ensembl
TCGA novel	94	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4184053 rs749967676	95	K>R		No	ClinGen ExAC gnomAD
CA366960564 rs1413500993	96	T>S		No	ClinGen gnomAD
TCGA novel	97	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4184051 rs777560167	98	P>Q		No	ClinGen ExAC gnomAD
rs1391535076 CA366960552	98	P>S		No	ClinGen gnomAD
CA4184050 rs751934843	99	E>K		No	ClinGen ExAC gnomAD
rs1200754339 CA366960539	100	V>A		No	ClinGen gnomAD
CA4184049 rs764560607	100	V>I		No	ClinGen ExAC gnomAD
rs764560607 CA366960541	100	V>L		No	ClinGen ExAC gnomAD
CA4184047 rs753237975	101	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1177529152 CA366960533	101	M>T		No	ClinGen TOPMed
rs1481060878 CA366960536	101	M>V		No	ClinGen TOPMed
rs201577034 CA4184017	102	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4184014 rs370049835	103	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4184013 rs370049835	103	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	104	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1229485030 CA366960464	109	D>E		No	ClinGen gnomAD
rs1246702633 CA366960463	110	D>N		No	ClinGen TOPMed
rs745803542 CA4184011	111	G>A		No	ClinGen ExAC TOPMed gnomAD
rs745803542 CA366960451	111	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1583845890 CA366960446	112	K>R		No	ClinGen Ensembl
CA366960442 rs1440789438	113	A>T		No	ClinGen gnomAD
CA366960425 rs1359283401	115	L>F		No	ClinGen gnomAD
CA366960427 rs1230853831	115	L>S		No	ClinGen gnomAD
CA366960422 rs1335761865	116	V>L		No	ClinGen TOPMed gnomAD
CA366960423 rs1335761865	116	V>M		No	ClinGen TOPMed gnomAD
CA4184009 rs142981617	118	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA366960395 rs746581280	119	E>D		No	ClinGen ExAC TOPMed gnomAD
CA366960391 rs1257002911	120	E>A		No	ClinGen TOPMed
CA4184006 rs558132059	120	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs369568135 CA4184007	120	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4184005 rs137919998	122	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150333184 CA4184004	123	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4184002 rs1554295801	126	D>E		No	ClinGen Ensembl
rs755449955 CA4184000	127	K>*		No	ClinGen ExAC gnomAD
TCGA novel	127	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376335429 CA4183999	129	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA366960327 rs376335429	129	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs750543368 CA4183997	130	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750543368 CA4183996	130	P>R		No	ClinGen ExAC gnomAD
rs1583845753 CA366960312	132	R>G		No	ClinGen Ensembl
rs767757196 CA4183995	132	R>S		No	ClinGen ExAC gnomAD
rs761972880 CA4183994	134	R>T		No	ClinGen ExAC gnomAD
rs752469383 CA366960270	135	S>A		No	ClinGen ExAC gnomAD
CA4183993 rs752469383	135	S>T		No	ClinGen ExAC gnomAD
CA366960262 rs1449937921	136	R>G		No	ClinGen TOPMed gnomAD
rs972761529 CA155126949	136	R>T		No	ClinGen Ensembl
rs759460317 CA4183991	137	R>S		No	ClinGen ExAC TOPMed gnomAD
rs761733292	137	R>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4183988 rs776702624	139	S>N		No	ClinGen ExAC gnomAD
rs200891942 CA4183987	140	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs987310773 CA366960195	141	G>R		No	ClinGen gnomAD
rs987310773 CA155126935	141	G>S		No	ClinGen gnomAD
CA4183986 rs371638574	142	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	142	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366960173 rs1240634203	143	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4183985 rs141140287	143	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA366960164 rs1442959759	144	V>I		No	ClinGen gnomAD
rs1345658094 CA366960125 COSM1755212	147	Q>*	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA155126924 rs909753364	147	Q>R		No	ClinGen TOPMed
rs779282166 CA4183982	148	F>I		No	ClinGen ExAC gnomAD
CA155126919 rs983978413	148	F>L		No	ClinGen TOPMed gnomAD
rs768997741 CA4183981 COSM1088472	150	T>A	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs367949098 CA155126911	150	T>I		No	ClinGen 1000Genomes ESP gnomAD
rs1215614532 CA366960056	152	K>T		No	ClinGen gnomAD
CA4183980 rs749722138	153	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1291340195 CA366960030	154	A>V		No	ClinGen gnomAD
CA4183979 rs780509440	155	N>D		No	ClinGen ExAC gnomAD
rs148205645 CA4183978	155	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA366960000 rs750462397	157	P>A		No	ClinGen ExAC TOPMed gnomAD
CA366959995 rs1436905850	157	P>R		No	ClinGen gnomAD
CA4183977 rs750462397	157	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4183976 rs781136077	158	D>H		No	ClinGen ExAC gnomAD
CA4183975 rs143179934	159	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1207686990 CA366959964	160	N>H		No	ClinGen gnomAD
rs1437040046 CA366959959	160	N>S		No	ClinGen gnomAD
TCGA novel	161	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759370631 CA4183972	164	E>K		No	ClinGen ExAC gnomAD
CA4183970 rs142227347	166	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs760730241 CA4183969	167	F>L		No	ClinGen ExAC
rs771498809 CA4183965	168	S>C		No	ClinGen ExAC gnomAD
CA4183963 rs773872806	170	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4183962 rs374550676	171	R>C	Variant assessed as Somatic; 9.275e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
COSM600619 CA4183961 rs201734057	171	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA366959820 rs374550676	171	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA366959790 rs1562622649	173	Q>R		No	ClinGen Ensembl
rs1583845471 CA366959768	175	E>K		No	ClinGen Ensembl
rs528806227 CA4183960	177	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA366959712 rs1358091441	179	I>L		No	ClinGen TOPMed gnomAD
rs760707123 CA155126861	179	I>T		No	ClinGen Ensembl
rs1358091441 CA366959714	179	I>V		No	ClinGen TOPMed gnomAD
COSM279752 rs770218756 CA4183959	180	L>I	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA155126856 rs1031964759	181	E>Q		No	ClinGen Ensembl
CA4183958 rs746374294	182	R>G		No	ClinGen ExAC gnomAD
CA366959676 rs1301925219	182	R>T		No	ClinGen TOPMed
rs1294527705 CA366959672	183	K>Q		No	ClinGen gnomAD
rs781750531 CA366959660	184	K>R		No	ClinGen ExAC TOPMed gnomAD
rs781750531 CA4183957	184	K>T		No	ClinGen ExAC TOPMed gnomAD
CA4183954 rs757277115	187	R>G		No	ClinGen ExAC TOPMed gnomAD
rs35281045 CA155126842 VAR_050776	187	R>S		No	ClinGen UniProt Ensembl dbSNP
CA4183953 rs747150378	187	R>T		No	ClinGen ExAC gnomAD
rs778114786 CA366959636	188	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs778114786 CA4183952	188	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs904686660 CA155126837	188	Q>H		No	ClinGen TOPMed
CA366959617 rs1364964545	191	Q>K		No	ClinGen gnomAD
CA4183951 rs758712356	192	R>K		No	ClinGen ExAC gnomAD
rs1463675694 CA366959600	193	E>A		No	ClinGen gnomAD
rs146976111 CA366959590	194	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA4183949 rs560042862	194	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs201363125 CA155126826	195	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201363125 CA4183947	195	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201363125 CA366959586	195	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1046584240 CA155126821	196	T>A		No	ClinGen TOPMed
CA366959581 rs1370696949	196	T>I		No	ClinGen gnomAD
rs1490331497 CA366959574	198	E>*		No	ClinGen gnomAD
CA366959559 rs1193503419	200	E>K		No	ClinGen TOPMed
rs761198537 CA4183945	201	D>G		No	ClinGen ExAC TOPMed gnomAD
rs761198537 CA366959548	201	D>V		No	ClinGen ExAC TOPMed gnomAD
CA4183944 rs371377746	202	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200919907 CA4183943	203	S>C		No	ClinGen ExAC gnomAD
rs200919907 CA366959534	203	S>F		No	ClinGen ExAC gnomAD
rs563675406 CA366959533	204	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4183941 rs775772395	204	R>P		No	ClinGen ExAC TOPMed gnomAD
CA366959532 rs775772395	204	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs563675406 CA4183942	204	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1333079098 CA366959525	205	D>V		No	ClinGen TOPMed
rs1281141176 CA366959518	206	E>G		No	ClinGen gnomAD
CA366959522 rs1313733569	206	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1289023037 CA366959486	210	S>N		No	ClinGen TOPMed gnomAD
CA366959487 rs1289023037	210	S>T		No	ClinGen TOPMed gnomAD
rs746309699 CA4183939	211	S>*		No	ClinGen ExAC TOPMed gnomAD
rs767651522 CA366959443	215	L>M		No	ClinGen TOPMed gnomAD
rs767651522 CA155126790	215	L>V		No	ClinGen TOPMed gnomAD
rs1408673340 CA366959418	217	R>K		No	ClinGen gnomAD
CA366959406 rs1209896700	218	T>S		No	ClinGen Ensembl
rs758630757 CA4183934	219	M>T		No	ClinGen ExAC TOPMed gnomAD
CA4183935 rs778026662	219	M>V		No	ClinGen ExAC gnomAD
CA366959360 rs1184659291	221	I>M		No	ClinGen gnomAD
CA366959351 rs1052204522	222	K>N		No	ClinGen TOPMed gnomAD
rs755859959 CA4183931	224	N>K		No	ClinGen ExAC TOPMed gnomAD
rs750275136 CA4183930	225	K>R		No	ClinGen ExAC gnomAD
rs1583845151 CA366959289	227	M>I		No	ClinGen Ensembl
rs188087480 CA4183894	230	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs369952841 CA4183892	233	A>E		No	ClinGen ExAC gnomAD
rs867714547 CA155126094	233	A>S		No	ClinGen Ensembl
rs369952841 COSM746438 CA4183891	233	A>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA366959135 rs1407369563	234	E>D		No	ClinGen TOPMed gnomAD
rs1464271553 CA366959145	234	E>K		No	ClinGen TOPMed
CA366959119 rs1302003238	236	N>D		No	ClinGen gnomAD
CA155126078 rs976023639	236	N>K		No	ClinGen Ensembl
rs770755131 CA4183890	237	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA366959060 rs1474948765	241	F>I		No	ClinGen gnomAD
CA4183888 rs201701551	242	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM243587 rs200458641 CA4183886	244	V>A	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA366959029 rs1489841906	244	V>I		No	ClinGen gnomAD
COSM159878 CA366959018 rs1221878454	245	R>*	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs771556634 CA155126048	245	R>P		No	ClinGen ExAC TOPMed gnomAD
rs771556634 CA4183885	245	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs754532598 CA4183884	247	P>A		No	ClinGen ExAC TOPMed gnomAD
CA366959003 rs754532598	247	P>S		No	ClinGen ExAC TOPMed gnomAD
rs567337409 CA4183883	248	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA366958992 rs1339132951	248	T>I		No	ClinGen gnomAD
CA366958977 rs1255662567	250	A>P		No	ClinGen TOPMed
rs141349806 CA4183882	250	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4183881 rs540748332	251	S>F		No	ClinGen ExAC gnomAD
rs745529677 CA4183842	254	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1242922051 CA366958871	255	T>I		No	ClinGen gnomAD
CA4183841 rs560390424	256	V>A		No	ClinGen ExAC TOPMed gnomAD
CA366958867 rs1319308700	256	V>L		No	ClinGen gnomAD
CA155125865 COSM338028 rs922366893	258	R>Q	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA4183840 rs757664469 COSM1088470	258	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA366958835 rs1583842976	259	A>G		No	ClinGen Ensembl
CA366958840 rs145238615	259	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA4183839 rs145238615	259	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA155125861 rs898050182	260	F>L		No	ClinGen TOPMed gnomAD
CA366958817 rs763552835	261	S>*		No	ClinGen ExAC TOPMed gnomAD
CA4183837 COSM1698405 rs763552835	261	S>L	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs764612197 CA4183838	261	S>T		No	ClinGen ExAC gnomAD
rs1432782295 CA366958790	264	Q>E		No	ClinGen gnomAD
rs759666563 CA4183835 CA4183834	264	Q>H		No	ClinGen ExAC gnomAD
CA4183833 rs749671239	265	I>T		No	ClinGen ExAC TOPMed gnomAD
rs377604487 CA4183832	266	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4183828 rs762805490	267	R>Q		No	ClinGen ExAC gnomAD
CA4183829 COSM159877 rs768599738	267	R>W	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA155125816 rs1045499113	268	R>C		No	ClinGen TOPMed gnomAD
CA4183827 rs775082493	268	R>H		No	ClinGen ExAC gnomAD
CA366958750 rs775082493	268	R>P		No	ClinGen ExAC gnomAD
rs1240817956 CA366958740	269	M>T		No	ClinGen gnomAD
CA366958746 rs1213958691	269	M>V		No	ClinGen TOPMed
CA366958726 rs1583842870	270	N>T		No	ClinGen Ensembl
CA4183824 rs780969974	271	P>R		No	ClinGen ExAC gnomAD
rs948414964 CA155125794	272	T>A		No	ClinGen TOPMed gnomAD
rs770728898 CA366958703	272	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4183823 rs770728898	272	T>N		No	ClinGen ExAC TOPMed gnomAD
rs139249411 CA4183822	273	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1295990655 CA366958696	274	S>G		No	ClinGen gnomAD
rs1216067523 CA366958694	274	S>N		No	ClinGen gnomAD
rs1583842817 CA366958690	274	S>R		No	ClinGen Ensembl
rs778002499 COSM1449998 CA4183821	275	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1366267269 CA366958683	276	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4183818 rs779466315	276	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1337148711 CA366958674	278	P>S		No	ClinGen TOPMed gnomAD
CA366958672 rs1337148711	278	P>T		No	ClinGen TOPMed gnomAD
CA155125767 rs1054503511	284	E>G		No	ClinGen TOPMed
rs372997607 CA4183816	284	E>Q		No	ClinGen ESP ExAC gnomAD
CA366958627 rs1354316523	285	N>H		No	ClinGen gnomAD
CA366958621 rs924511731 CA155125759	285	N>K		No	ClinGen TOPMed gnomAD
CA366958623 rs1282404958	285	N>S		No	ClinGen TOPMed gnomAD
CA366958624 rs1282404958	285	N>T		No	ClinGen TOPMed gnomAD
CA4183814 rs760840017	286	F>Y		No	ClinGen ExAC gnomAD
CA366958607 rs1291042776	288	V>I		No	ClinGen TOPMed
rs762865786 CA4183811	290	A>D		No	ClinGen ExAC TOPMed gnomAD
CA366958591 rs762865786	290	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4183808 rs375745418	291	A>T		No	ClinGen ExAC gnomAD
CA4183807 rs776311696	291	A>V		No	ClinGen ExAC gnomAD
TCGA novel	291	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1583842663 CA366958583	292	K>T		No	ClinGen Ensembl
CA366958575 rs770546760	293	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1224029346 CA366958576	293	F>V		No	ClinGen gnomAD
CA4183805 rs770546760	293	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs746650414 CA4183804	294	A>P		No	ClinGen ExAC TOPMed gnomAD
rs777536863 CA4183803	294	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1235471317 CA366958565	295	E>K		No	ClinGen TOPMed
rs905028335 CA155125680	296	E>G		No	ClinGen Ensembl
CA4183801 rs748589038	296	E>K		No	ClinGen ExAC gnomAD
rs140167617 CA4183800	298	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369531494 CA4183798	301	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs780113859 CA4183797	301	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1250616458 CA366958503	304	K>*		No	ClinGen gnomAD
CA4183795 rs750600045	304	K>N		No	ClinGen ExAC gnomAD
rs767849344 CA4183794	305	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA366958497 rs767849344	305	T>P		No	ClinGen ExAC TOPMed gnomAD
rs758104439 CA366958490	306	I>N		No	ClinGen ExAC TOPMed gnomAD
rs758104439 CA4183793	306	I>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	307	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1583841781 CA366958449	310	C>*		No	ClinGen Ensembl
COSM1088468 rs371749596 CA4183766	311	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4183767 rs772804561	311	R>W		No	ClinGen ExAC TOPMed gnomAD
CA4183765 rs761462775	312	E>Q		No	ClinGen ExAC gnomAD
CA4183763 rs768995761	315	R>*		No	ClinGen ExAC TOPMed gnomAD
rs768995761 CA366958422	315	R>G		No	ClinGen ExAC TOPMed gnomAD
rs949363780 CA155125095	315	R>Q		No	ClinGen TOPMed gnomAD
rs775830609 CA4183761	316	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4183762 rs775830609	316	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4183760 rs770354618	316	R>H		No	ClinGen ExAC gnomAD
CA366958417 rs770354618	316	R>L		No	ClinGen ExAC gnomAD
CA4183759 rs745894405	317	H>R		No	ClinGen ExAC gnomAD
rs368758057 CA4183758	318	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4183757 COSM485196 rs146158399	318	R>H	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs368758057 CA366958408	318	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs142943530 CA366958405	319	I>L		No	ClinGen ESP ExAC gnomAD
rs142943530 CA4183756	319	I>V		No	ClinGen ESP ExAC gnomAD
CA155125027 rs1018175819	320	S>F		No	ClinGen Ensembl
rs1006484019 CA155125024	321	S>C		No	ClinGen Ensembl
rs754786484 CA4183754	323	R>L		No	ClinGen ExAC gnomAD
rs754786484 CA4183755	323	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA366958381 rs1157365721	323	R>W		No	ClinGen TOPMed gnomAD
rs781742118 CA155125018	324	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1241259754 CA366958359	327	D>N		No	ClinGen TOPMed
TCGA novel	328	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4183752 rs540501423	328	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4183750 rs377233838	330	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA155125009 rs377233838	330	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs189760165 CA4183749	331	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA155125005 rs891581588	331	E>Q		No	ClinGen Ensembl
CA4183748 rs761371148	332	D>H		No	ClinGen ExAC gnomAD
rs1162307732 CA366958304	335	N>D		No	ClinGen gnomAD
CA155124989 rs925547232	336	V>I		No	ClinGen TOPMed gnomAD
CA366958289 rs1454648321	337	A>D		No	ClinGen TOPMed
CA4183747 rs751210112	338	I>V		No	ClinGen ExAC gnomAD
rs1583841581 CA366958279	339	T>A		No	ClinGen Ensembl
CA366958274 rs1190928937	340	V>I		No	ClinGen gnomAD
rs763777079 CA366958268 COSM1088467	341	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4183746 rs763777079	341	R>G		No	ClinGen ExAC TOPMed gnomAD
rs770133053 CA4183743	344	I>M		No	ClinGen ExAC gnomAD
rs775952516 CA4183744	344	I>V		No	ClinGen ExAC gnomAD
rs760100535 CA4183742	345	Y>C		No	ClinGen ExAC gnomAD
CA366958240 rs760100535	345	Y>F		No	ClinGen ExAC gnomAD
rs1381312612 CA366958224	347	K>R		No	ClinGen TOPMed
rs1583841542 CA917961029	347	K>R		No	ClinGen Ensembl
CA4183741 rs777058471	348	V>L		No	ClinGen ExAC gnomAD
rs531936007 CA155123616	351	N>H		No	ClinGen TOPMed gnomAD
rs779062145 CA366958187	351	N>K		No	ClinGen ExAC gnomAD
TCGA novel	352	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148567671 CA155123609	352	T>M		No	ClinGen ESP TOPMed gnomAD
rs1181499059 CA366958172	354	H>Y		No	ClinGen TOPMed
rs745692053 CA4183713	357	R>*		No	ClinGen ExAC TOPMed gnomAD
rs745692053 CA366958148	357	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1218303057 CA366958146	357	R>P		No	ClinGen gnomAD
rs757215983 CA4183711	360	T>S		No	ClinGen ExAC
CA366958118 rs144495438	361	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777278383 CA4183708	361	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	362	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1356964066 CA366958100	364	K>T		No	ClinGen TOPMed
CA366958089 rs1338520760	366	V>M		No	ClinGen TOPMed gnomAD
CA366958074 rs1358467264	368	R>P		No	ClinGen TOPMed gnomAD
CA366958073 rs1358467264	368	R>Q		No	ClinGen TOPMed gnomAD
CA4183702 rs149281501	368	R>W		No	ClinGen ESP ExAC gnomAD
rs1401302083 CA366958065 CA366958064	369	N>K		No	ClinGen gnomAD
rs773371427 CA4183700	373	C>W		No	ClinGen ExAC gnomAD
CA366958021 rs1376467091	376	R>*		No	ClinGen TOPMed gnomAD
CA155123544 rs761110991	376	R>Q		No	ClinGen TOPMed
CA155123527 rs376408493	382	P>L		No	ClinGen ESP TOPMed gnomAD
TCGA novel	383	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4183697 rs774602757	383	C>R		No	ClinGen ExAC TOPMed gnomAD
CA4183694 rs138465359	385	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA366957957 rs1583839242	386	N>S		No	ClinGen Ensembl
CA155123513 rs768924803 COSM1200396	387	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA366957949 rs1215416947	387	R>H		No	ClinGen gnomAD
rs770795151 CA4183693	389	G>R		No	ClinGen ExAC gnomAD
rs1316759729 CA366957925	391	D>Y		No	ClinGen gnomAD
CA155123505 rs879534504	392	V>F		No	ClinGen Ensembl
CA366957912 rs1251576225	393	R>K		No	ClinGen TOPMed
CA366957911 rs1251576225	393	R>T		No	ClinGen TOPMed
CA4183692 rs187980810	394	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1378189271 CA366957907	394	S>P		No	ClinGen gnomAD
rs1296475750 CA366957869	399	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA155118216 rs368980248	401	W>S		No	ClinGen ESP TOPMed
CA366957837 rs1250731649	402	V>A		No	ClinGen gnomAD
CA4183647 rs559237991	402	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA366957840 rs559237991	402	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1232633977 CA366957826	404	P>A		No	ClinGen TOPMed
CA366957821 rs1484219582	405	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1562618642 CA572926281	406	C>*		No	ClinGen Ensembl
rs1322455732 CA366957814	406	C>G		No	ClinGen TOPMed
CA366957813 rs1322455732	406	C>R		No	ClinGen TOPMed
rs1562618639 CA366957812	406	C>Y		No	ClinGen Ensembl
rs768050489 CA4183641	407	R>C		No	ClinGen ExAC TOPMed gnomAD
rs768050489 CA4183640	407	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1562618618 CA366957800	408	G>E		No	ClinGen Ensembl
rs1231104619 CA366957802	408	G>R		No	ClinGen gnomAD
rs1311697391 CA366957785	410	C>Y		No	ClinGen gnomAD
CA366957778 rs1465264468	411	N>S		No	ClinGen gnomAD
rs879754457 CA366957754	414	Y>F		No	ClinGen TOPMed gnomAD
rs879754457 CA155118183	414	Y>S		No	ClinGen TOPMed gnomAD
CA155118144 rs995765441	416	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs368150780 CA155118150	416	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
CA366957734 rs1331157404	417	K>N		No	ClinGen gnomAD
rs748848014 CA4183639	418	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766188645 CA4183638	418	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
rs769315810 CA4183635	419	D>E		No	ClinGen ExAC
rs1256846966 CA366957726	419	D>N		No	ClinGen gnomAD
rs1301630062 CA366957720 COSM1088465	420	G>S	Variant assessed as Somatic; 0.0 impact. endometrium prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs199585313 CA4183633	421	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4183632 rs757696242	421	R>H		No	ClinGen ExAC TOPMed gnomAD
CA366957709 rs1379426196	422	C>R		No	ClinGen gnomAD
rs1299767891 CA366957675	427	L>F		No	ClinGen TOPMed
CA4183630 rs758446964	429	H>N		No	ClinGen ExAC gnomAD
CA4183629 rs758446964	429	H>Y		No	ClinGen ExAC gnomAD
CA366957627 rs1286904628	434	Y>C		No	ClinGen gnomAD
CA155118031 rs891183747	434	Y>H		No	ClinGen Ensembl
rs765401220 CA4183626	435	G>S		No	ClinGen ExAC gnomAD
rs1230153504 CA366957605	437	D>E		No	ClinGen TOPMed
rs750177138 CA4183624	437	D>G		No	ClinGen ExAC TOPMed gnomAD
rs767205857 CA366957604	438	N>D		No	ClinGen ExAC TOPMed gnomAD
rs767205857 CA4183623	438	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1396026072 CA366957587	440	K>R		No	ClinGen gnomAD
TCGA novel	441	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1255612164 CA366957577	441	E>D		No	ClinGen gnomAD
rs1359449685 CA366957551	445	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA366957525 rs1198433095	447	Q>*		No	ClinGen gnomAD
rs16891988 CA4183578 COSM183085	447	Q>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA366957511 rs1457742607	449	E>Q		No	ClinGen gnomAD
CA4183574 rs748642695	451	V>A		No	ClinGen ExAC
CA4183575 rs141309943	451	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs749434728 CA4183571	452	E>D		No	ClinGen ExAC gnomAD
CA4183572 rs569049138	452	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs569049138 CA4183573	452	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA366957492 rs1562617547	452	E>V		No	ClinGen Ensembl
rs148258753 CA4183569	454	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1562617522 CA917961302	455	N>S		No	ClinGen Ensembl

No associated diseases with Q96GN5

No regional properties for Q96GN5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96GN5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Associates with chromatin Translocates from cytoplasm to nucleus under dexamethasone induction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name	Definition
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MELATRYQIP	KEVADIFNAP	SDDEEFVGFR	DDVPMETLSS	EESCDSFDSL	ESGKQQDVRF
70	80	90	100	110	120
HSKYFTEELR	RIFIEDTDSE	TEDFAGFTQS	DLNGKTNPEV	MVVESDLSDD	GKASLVSEEE
130	140	150	160	170	180
EDEEEDKATP	RRSRSRRSSI	GLRVAFQFPT	KKLANKPDKN	SSSEQLFSSA	RLQNEKKTIL
190	200	210	220	230	240
ERKKDCRQVI	QREDSTSESE	DDSRDESQES	SDALLKRTMN	IKENKAMLAQ	LLAELNSMPD
250	260	270	280	290	300
FFPVRTPTSA	SRKKTVRRAF	SEGQITRRMN	PTRSARPPEK	FALENFTVSA	AKFAEEFYSF
310	320	330	340	350	360
RRRKTIGGKC	REYRRRHRIS	SFRPVEDITE	EDLENVAITV	RDKIYDKVLG	NTCHQCRQKT
370	380	390	400	410	420
IDTKTVCRNQ	GCCGVRGQFC	GPCLRNRYGE	DVRSALLDPD	WVCPPCRGIC	NCSYCRKRDG
430	440	450
RCATGILIHL	AKFYGYDNVK	EYLESLQKEL	VEDN