AiPD: Autoinhibited Protein Database

Q96FF9

Gene name	CDCA5
Protein name	Sororin
Names	Cell division cycle-associated protein 5, p35
Species	Homo sapiens (Human)
KEGG Pathway	hsa:113130
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-247 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-247 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96FF9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96FF9-F1	Predicted				AlphaFoldDB

192 variants for Q96FF9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs776825000 CA6089776	2	S>A		No	ClinGen ExAC gnomAD
rs1158911582 CA381220250	3	G>A		No	ClinGen TOPMed
CA381220251 rs1158911582	3	G>E		No	ClinGen TOPMed
CA223938818 rs549327680	3	G>R		No	ClinGen 1000Genomes
CA6089775 rs535457002	4	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381220233 rs746580955	6	T>K		No	ClinGen ExAC TOPMed gnomAD
CA6089774 rs746580955	6	T>R		No	ClinGen ExAC TOPMed gnomAD
CA381220222 rs1317536118	8	S>F		No	ClinGen TOPMed
CA223938812 rs939247293	10	G>R		No	ClinGen TOPMed gnomAD
CA6089773 rs772912965	11	A>V		No	ClinGen ExAC gnomAD
rs771701995 CA6089772	13	Q>*		No	ClinGen ExAC gnomAD
rs201897046 CA6089755	16	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA223938806 rs1029814204	16	G>R		No	ClinGen TOPMed
CA381220159 rs1427444723	17	P>L		No	ClinGen gnomAD
rs568903301 CA6089754	18	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	19	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771755340 CA6089753	19	A>V		No	ClinGen ExAC gnomAD
rs1268014123	20	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs747682447 CA6089752	20	P>S		No	ClinGen ExAC gnomAD
CA6089750 rs895256499	23	T>A		No	ClinGen TOPMed
rs1222545049 CA381220115	25	P>S		No	ClinGen gnomAD
rs528873093 CA6089746	27	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA381220106 rs1307086737	27	R>W		No	ClinGen TOPMed gnomAD
CA6089745 rs779966680	28	R>M		No	ClinGen ExAC TOPMed gnomAD
CA381220092 rs1414516250	29	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs200080207 CA6089743	30	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs200080207 CA6089742	30	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA381220083 rs1403537846	31	R>W		No	ClinGen gnomAD
CA381220076 rs1370136390	32	K>T		No	ClinGen TOPMed gnomAD
CA6089740 rs758582969	34	G>S		No	ClinGen ExAC gnomAD
CA6089739 rs752782722	38	P>L		No	ClinGen ExAC TOPMed gnomAD
rs147681486 CA6089737	39	S>R		No	ClinGen ESP ExAC gnomAD
CA6089738 rs376204219	39	S>T		No	ClinGen ESP ExAC
rs1565292729 CA381220023	40	I>M		No	ClinGen Ensembl
CA381220010 rs1252503398	43	E>Q		No	ClinGen TOPMed
rs754293224 CA6089736	44	I>S		No	ClinGen ExAC TOPMed gnomAD
rs1565292681 CA381220001	44	I>V		No	ClinGen Ensembl
rs756602663 CA6089716	48	T>I		No	ClinGen ExAC TOPMed gnomAD
CA381219954 rs750822315	49	P>A		No	ClinGen ExAC TOPMed
CA6089715 rs750822315	49	P>S		No	ClinGen ExAC TOPMed
rs767980109 CA6089714	50	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6089713 rs761626035	51	A>E		No	ClinGen ExAC gnomAD
CA381219943 rs1208310144	51	A>T		No	ClinGen TOPMed
CA6089710 rs145471269	60	L>F		No	ClinGen ESP ExAC
rs552011635 CA223938664	61	K>R		No	ClinGen Ensembl
CA381219870 rs1180707332	62	R>K		No	ClinGen gnomAD
CA6089709 rs376710891	65	A>V		No	ClinGen ESP ExAC gnomAD
CA6089708 rs769620516	66	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	67	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	67	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141510349 CA223938658	68	V>I		No	ClinGen ESP TOPMed gnomAD
rs1238860244 CA381219827	69	E>*		No	ClinGen gnomAD
CA381219799 rs1288632821	71	P>L		No	ClinGen gnomAD
rs751922522 CA6089695	71	P>S		No	ClinGen ExAC TOPMed gnomAD
rs763682096 CA223938626	72	A>D		No	ClinGen ExAC TOPMed gnomAD
rs763682096 CA6089694	72	A>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	73	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757998694 CA6089693	73	V>F		No	ClinGen ExAC gnomAD
CA381219786 rs1312443703	74	Q>R		No	ClinGen gnomAD
CA381219773 rs1340513674	76	P>S		No	ClinGen gnomAD
CA381219737 rs895632769	81	R>S		No	ClinGen TOPMed
CA223937735 rs573563212	85	F>S		No	ClinGen Ensembl
CA381219622 rs1343380639	89	E>Q		No	ClinGen gnomAD
rs1391652141 CA381219576	92	P>R		No	ClinGen gnomAD
CA6089677 rs747336878	92	P>S		No	ClinGen ExAC gnomAD
rs1167475896 CA381219566	93	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381219561 rs1159308751	94	G>V		No	ClinGen gnomAD
CA381219553 rs1464118303	95	R>K		No	ClinGen gnomAD
rs1426470538 CA381219519	98	T>A		No	ClinGen gnomAD
CA223937724 rs950830051	99	K>N		No	ClinGen TOPMed gnomAD
rs1480371795 CA381219498	100	E>K		No	ClinGen gnomAD
rs1245363652 CA381219483	101	D>N		No	ClinGen gnomAD
CA223937721 rs1047524076	105	T>I		No	ClinGen TOPMed gnomAD
rs1249380193 CA381219409	106	H>Q		No	ClinGen gnomAD
CA381219399 rs1590798344	107	S>I		No	ClinGen Ensembl
CA6089672 rs764770497	108	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs370550690 CA6089671	109	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1276411076 CA381219365	110	A>T		No	ClinGen gnomAD
CA381219325 rs1590798291	113	T>I		No	ClinGen Ensembl
CA381219301 rs1436851156	115	T>I		No	ClinGen gnomAD
rs1331957370 CA381219292	116	P>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381219287 rs1327754432	117	V>M		No	ClinGen TOPMed gnomAD
rs1328409366 CA381219271	118	P>L		No	ClinGen TOPMed gnomAD
CA381219273 rs1328409366	118	P>R		No	ClinGen TOPMed gnomAD
rs927250701 CA223937703	120	P>A		No	ClinGen TOPMed
rs760541197 CA6089668	120	P>L		No	ClinGen ExAC TOPMed gnomAD
CA223937700 rs760541197	120	P>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	122	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140084832 RCV000893617 CA6089664	123	E>K		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA381219197 rs1590798202	124	S>P		No	ClinGen Ensembl
CA223937687 rs1032797270	127	K>R		No	ClinGen TOPMed gnomAD
CA381219153 rs1176366115	128	E>K		No	ClinGen gnomAD
CA381219141 rs1458788417	129	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381219126 rs1238277384	130	E>K		No	ClinGen TOPMed gnomAD
rs1238277384 CA381219128	130	E>Q		No	ClinGen TOPMed gnomAD
CA381219090 rs1440635046	133	A>P		No	ClinGen gnomAD
rs771575347 CA6089660	135	D>E		No	ClinGen ExAC gnomAD
CA381219051 rs1221723823	136	L>S		No	ClinGen TOPMed
rs747534219 CA6089659	138	M>I		No	ClinGen ExAC gnomAD
CA381219025 rs1565285573	139	S>F		No	ClinGen Ensembl
rs199554686 CA6089658	140	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772455740 CA6089657	143	R>W		No	ClinGen ExAC gnomAD
rs747808569 COSM930311 CA6089656	144	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs778562586 CA6089655	144	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1223629758 CA381218988	145	S>C		No	ClinGen TOPMed
CA381218991 rs1447380355	145	S>T		No	ClinGen gnomAD
rs754587257 CA381218985	146	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs754587257 CA6089654	146	Y>N		No	ClinGen ExAC TOPMed gnomAD
CA6089652 rs779482681	148	R>Q		No	ClinGen ExAC gnomAD
rs753353314 CA6089653	148	R>W		No	ClinGen ExAC gnomAD
CA223937666 rs35748530	149	L>V		No	ClinGen TOPMed
TCGA novel	151	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs932404002 CA223937662	153	G>R		No	ClinGen Ensembl
rs756065002 CA6089651	155	A>P		No	ClinGen ExAC TOPMed gnomAD
rs756065002 CA223937659	155	A>T		No	ClinGen ExAC TOPMed gnomAD
rs750342876 CA6089650	155	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA223937653 rs34020666 VAR_050777	156	S>Y		No	ClinGen UniProt Ensembl dbSNP
CA6089649 rs767264827	157	T>I		No	ClinGen ExAC gnomAD
CA381218875 rs1590798004	157	T>P		No	ClinGen Ensembl
rs1158272586 CA381218862	158	S>A		No	ClinGen TOPMed
CA381218846 rs1210764578	159	T>I		No	ClinGen gnomAD
rs1590797979 CA381218854	159	T>P		No	ClinGen Ensembl
TCGA novel	162	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381218818 rs1446304564	162	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA381218815 rs1446304564	162	R>L		No	ClinGen gnomAD
rs765558696 CA6089646	163	R>Q		No	ClinGen ExAC gnomAD
rs751358434 CA6089647	163	R>W		No	ClinGen ExAC TOPMed gnomAD
CA381218741 rs1340393208	169	E>K		No	ClinGen gnomAD
rs761130860 CA6089642	172	L>V		No	ClinGen ExAC gnomAD
CA223937630 rs867225522	173	G>E		No	ClinGen Ensembl
CA381218707 CA381218708 rs1162500112	173	G>R		No	ClinGen TOPMed gnomAD
CA381218706 rs1162500112	173	G>W		No	ClinGen TOPMed gnomAD
CA381218693 rs1590797878	175	E>G		No	ClinGen Ensembl
RCV000962174 CA6089637 rs34032604	179	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA381218658 rs1260925948	180	V>G		No	ClinGen gnomAD
rs768312450 CA6089636	181	S>L		No	ClinGen ExAC gnomAD
CA381218646 rs1488483524	183	V>L		No	ClinGen gnomAD
rs1195970603 CA381218636	184	V>G		No	ClinGen TOPMed gnomAD
rs779606963 CA6089634	184	V>L		No	ClinGen ExAC gnomAD
CA381218631 rs1590797813	185	C>Y		No	ClinGen Ensembl
CA6089633 rs755628378	186	S>A		No	ClinGen ExAC TOPMed gnomAD
rs148016184 CA6089631 COSM2165001	190	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA381218589 rs1358558055 COSM3359318	192	P>S	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed
rs950964467 CA223937608	194	V>I		No	ClinGen TOPMed
rs751411625 CA6089629	195	C>F		No	ClinGen ExAC gnomAD
rs1027807778 CA223937605	195	C>R		No	ClinGen TOPMed
rs1341553675 CA381218564	196	A>P		No	ClinGen gnomAD
rs1433865882 CA381218559	197	K>E		No	ClinGen gnomAD
rs1464634348 CA381218546	198	P>L		No	ClinGen TOPMed gnomAD
CA381218549 rs1164938683	198	P>S		No	ClinGen gnomAD
CA381218545 rs1473912082	199	W>R		No	ClinGen TOPMed
CA381218534 rs1590797739	200	A>P		No	ClinGen Ensembl
TCGA novel	200	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA223937598 rs533690572	202	D>A		No	ClinGen TOPMed gnomAD
CA381218521 rs533690572	202	D>G		No	ClinGen TOPMed gnomAD
rs937382401 CA223937591	203	M>T		No	ClinGen TOPMed
CA6089626 rs754077348	203	M>V		No	ClinGen ExAC gnomAD
rs1171108843 CA381218509	204	T>A		No	ClinGen TOPMed
CA6089625 rs766423263	206	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6089624 rs184338337	210	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1340659359 CA381218465	211	P>R		No	ClinGen TOPMed
TCGA novel	213	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6089619 rs774757594	213	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6089618 rs372928302	214	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA381218446 rs1221027653	214	K>I		No	ClinGen TOPMed gnomAD
rs1229047999 CA381218442	215	Q>E		No	ClinGen TOPMed
CA6089617 rs748979988	217	R>C		No	ClinGen ExAC gnomAD
CA6089616 rs771200184	217	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1225921314 CA381218420	218	K>R		No	ClinGen gnomAD
rs1031650732 CA223937568	220	K>N		No	ClinGen Ensembl
rs1279464273 CA381218391	222	M>V		No	ClinGen TOPMed
rs200209838 CA6089612	223	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA381218372 rs1397543836	224	E>D		No	ClinGen gnomAD
rs1181996867 CA381218369	225	I>V		No	ClinGen TOPMed
rs570301807 CA6089572	228	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6089570 rs773223782	229	E>D		No	ClinGen ExAC TOPMed gnomAD
rs760297100 CA6089568	233	W>S		No	ClinGen ExAC gnomAD
CA381217887 rs1298532202	234	A>T		No	ClinGen gnomAD
rs772783951 CA6089567	235	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6089565 rs200941468	237	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772151897 CA6089566	237	M>V		No	ClinGen ExAC gnomAD
CA6089563 rs138639197	238	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6089564 rs138639197	238	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs530338793 CA6089562	239	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs372545623 CA6089560	240	E>K		No	ClinGen ExAC TOPMed gnomAD
CA6089559 rs146179402	247	F>V		No	ClinGen ESP ExAC TOPMed
TCGA novel rs369116079 CA6089557	248	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ESP ExAC TOPMed gnomAD
CA6089558 rs777815769	248	D>G		No	ClinGen ExAC gnomAD
rs777815769 CA381217709	248	D>V		No	ClinGen ExAC gnomAD
rs1264809133 CA381217682	251	V>A		No	ClinGen gnomAD
CA6089554 rs759837525	252	E>A		No	ClinGen ExAC gnomAD
rs765678897 COSM1298400 CA6089555	252	E>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD

No associated diseases with Q96FF9

No regional properties for Q96FF9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96FF9

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome Cytoplasm	Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
protein-containing complex binding	Binding to a macromolecular complex.

8 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mitotic chromosome condensation	The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic metaphase plate congression	The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
mitotic sister chromatid cohesion	The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.
positive regulation of exit from mitosis	Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
regulation of cohesin loading	Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSGRRTRSGG	AAQRSGPRAP	SPTKPLRRSQ	RKSGSELPSI	LPEIWPKTPS	AAAVRKPIVL
70	80	90	100	110	120
KRIVAHAVEV	PAVQSPRRSP	RISFFLEKEN	EPPGRELTKE	DLFKTHSVPA	TPTSTPVPNP
130	140	150	160	170	180
EAESSSKEGE	LDARDLEMSK	KVRRSYSRLE	TLGSASTSTP	GRRSCFGFEG	LLGAEDLSGV
190	200	210	220	230	240
SPVVCSKLTE	VPRVCAKPWA	PDMTLPGISP	PPEKQKRKKK	KMPEILKTEL	DEWAAAMNAE
250
FEAAEQFDLL	VE