Q96ES7
PR
Gene name |
SGF29 |
Protein name |
SAGA-associated factor 29 |
Names |
Coiled-coil domain-containing protein 101, SAGA complex-associated factor 29 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:112869 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
9 structures for Q96ES7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3LX7 | X-ray | 178 A | A | 138-293 | PDB |
| 3ME9 | X-ray | 137 A | A/B | 115-293 | PDB |
| 3MEA | X-ray | 126 A | A | 129-291 | PDB |
| 3MET | X-ray | 200 A | A/B | 115-293 | PDB |
| 3MEU | X-ray | 128 A | A/B | 115-293 | PDB |
| 3MEV | X-ray | 183 A | A/B | 115-293 | PDB |
| 3MEW | X-ray | 192 A | A | 129-287 | PDB |
| 5C0M | X-ray | 160 A | A/B | 115-293 | PDB |
| AF-Q96ES7-F1 | Predicted | AlphaFoldDB |
133 variants for Q96ES7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA395346880 rs1430303935 |
2 | A>D | No |
ClinGen gnomAD |
|
|
rs1169285436 CA395346887 |
3 | L>F | No |
ClinGen gnomAD |
|
|
rs770242742 CA7982297 |
4 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA7982299 rs762637300 |
6 | A>V | No |
ClinGen ExAC gnomAD |
|
|
COSM1640448 CA279800232 rs939063356 |
7 | D>N | stomach [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs759577655 CA7982302 |
9 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7982303 rs767338373 |
9 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs769427594 CA279800233 |
10 | I>N | No |
ClinGen Ensembl |
|
|
rs1225684081 CA395346959 |
11 | A>T | No |
ClinGen gnomAD |
|
|
rs1252479639 CA395346967 |
11 | A>V | No |
ClinGen gnomAD |
|
|
rs1293504054 CA395347000 |
15 | T>A | No |
ClinGen gnomAD |
|
|
rs752580059 CA7982304 |
16 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1244820721 CA395347041 |
18 | H>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA395347045 rs1486792886 |
18 | H>Q | No |
ClinGen gnomAD |
|
|
rs755937399 CA7982305 |
23 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs146510287 CA7982306 |
23 | Q>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs760553306 CA7982322 |
28 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs763940356 CA7982323 |
28 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763940356 CA395347617 |
28 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7982324 rs143034336 |
29 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7982326 rs766477106 |
30 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1282090211 CA395347629 |
31 | S>C | No |
ClinGen gnomAD |
|
|
CA395347633 rs544441807 |
31 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs781275887 CA7982329 |
32 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1267343741 CA395347647 |
33 | H>P | No |
ClinGen gnomAD |
|
|
CA395347644 rs1168894549 |
33 | H>Y | No |
ClinGen TOPMed |
|
|
rs368734087 CA7982331 |
34 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA279800830 rs891927415 |
36 | V>M | No |
ClinGen Ensembl |
|
|
CA279800832 rs1010464659 |
38 | I>V | No |
ClinGen gnomAD |
|
|
rs1208227189 CA395347775 |
42 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
COSM184636 rs1596607013 CA395347811 |
44 | R>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA395347850 rs1445241705 |
46 | Q>L | No |
ClinGen TOPMed |
|
|
rs749649489 CA7982333 |
49 | N>I | No |
ClinGen ExAC gnomAD |
|
|
rs778394832 CA7982351 |
51 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1036820032 CA279800837 |
51 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1342992787 CA395348138 |
56 | R>Q | No |
ClinGen gnomAD |
|
|
CA279800997 rs371750928 |
57 | T>I | No |
ClinGen ESP |
|
|
CA279800999 rs930718016 |
59 | L>M | No |
ClinGen TOPMed |
|
|
rs1049141877 COSM969484 CA279801002 |
60 | R>C | large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs757587400 COSM1678964 CA7982353 |
60 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs533948701 CA7982356 |
66 | A>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM309889 rs533948701 CA7982355 |
66 | A>T | lung large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA279801015 rs71391315 |
71 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
| TCGA novel | 71 | E>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7982359 rs79832682 |
74 | C>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7982407 rs749137032 |
77 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA395349278 rs1169402444 |
78 | R>Q | No |
ClinGen gnomAD |
|
|
rs770851630 CA7982409 |
78 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs747288559 CA7982410 |
83 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1372132403 CA395349349 |
84 | I>F | No |
ClinGen gnomAD |
|
|
CA395349361 rs140198976 |
84 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7982412 rs776903564 |
85 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7982413 rs374007563 |
85 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA395349500 rs1297763036 |
95 | R>Q | No |
ClinGen gnomAD |
|
|
rs1445381813 CA395349607 |
97 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7982436 rs774745658 COSM969485 |
102 | G>S | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 103 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1414699067 CA395349703 |
105 | N>D | No |
ClinGen gnomAD |
|
|
CA395349704 rs1473190042 |
105 | N>S | No |
ClinGen gnomAD |
|
|
rs1159118899 CA395349732 |
107 | S>A | No |
ClinGen gnomAD |
|
|
CA395349762 rs1335689342 |
109 | P>S | No |
ClinGen gnomAD |
|
|
CA395349840 rs1310823588 |
115 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA395349838 rs1310823588 |
115 | R>G | No |
ClinGen gnomAD |
|
|
CA395349981 rs1460213064 |
126 | S>L | No |
ClinGen TOPMed |
|
|
rs1348555533 CA395350000 |
128 | M>L | No |
ClinGen gnomAD |
|
| TCGA novel | 129 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1231952672 CA395350018 |
129 | T>S | No |
ClinGen gnomAD |
|
|
CA395350044 rs1279501886 |
131 | P>R | No |
ClinGen gnomAD |
|
|
rs1442025423 CA395350048 |
132 | L>M | No |
ClinGen gnomAD |
|
|
CA395350050 rs1442025423 |
132 | L>V | No |
ClinGen gnomAD |
|
|
CA395350137 rs1483591585 |
138 | G>D | No |
ClinGen gnomAD |
|
|
CA395350223 rs1248912834 |
142 | P>S | No |
ClinGen gnomAD |
|
|
CA395350236 rs1391798517 |
143 | P>S | No |
ClinGen gnomAD |
|
|
CA7982455 rs759967139 |
147 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA395350354 rs1223714719 |
149 | P>A | No |
ClinGen TOPMed |
|
| TCGA novel | 149 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA279802951 rs926587525 |
151 | S>L | No |
ClinGen Ensembl |
|
|
rs772496317 CA7982456 |
152 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs775701541 CA395351641 |
154 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395351646 rs1430082693 |
155 | V>M | No |
ClinGen gnomAD |
|
|
CA395351701 rs1394252755 |
158 | P>R | No |
ClinGen TOPMed |
|
|
rs1459690214 CA395351820 |
164 | A>T | No |
ClinGen TOPMed |
|
|
CA395351831 COSM702750 rs1324158167 |
165 | R>W | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1438789081 CA395351882 |
167 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 168 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs559566970 CA7982461 |
169 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA395351990 rs1567293780 |
173 | E>K | No |
ClinGen Ensembl |
|
| TCGA novel | 176 | I>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395352152 rs1596609778 |
180 | V>G | No |
ClinGen Ensembl |
|
|
rs766264847 CA7982466 |
182 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395352196 rs766264847 |
182 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1191200895 CA395352248 |
184 | S>N | No |
ClinGen gnomAD |
|
|
rs2291938 CA279807515 |
190 | Y>C | No |
ClinGen gnomAD |
|
|
CA395352438 rs2291938 |
190 | Y>F | No |
ClinGen gnomAD |
|
|
CA279807522 rs201007376 |
191 | E>G | No |
ClinGen 1000Genomes |
|
| TCGA novel | 194 | D>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1467355196 CA395352554 |
195 | I>V | No |
ClinGen TOPMed |
|
|
CA279807529 rs1037704770 |
201 | E>A | No |
ClinGen Ensembl |
|
|
rs1024155716 CA279807612 |
202 | R>K | No |
ClinGen Ensembl |
|
|
CA7982511 rs758417441 |
204 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA7982510 rs758417441 |
204 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs112263572 CA7982512 |
207 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395352871 rs1207027680 |
207 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7982514 rs781720189 |
209 | R>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 210 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1408456821 CA395353001 |
212 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs770234688 CA7982516 |
216 | W>G | No |
ClinGen ExAC gnomAD |
|
|
CA279807628 rs866462965 |
218 | A>V | No |
ClinGen Ensembl |
|
|
CA395353253 rs1238108223 |
222 | T>R | No |
ClinGen TOPMed |
|
|
CA7982519 rs770359939 |
227 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA7982520 rs773897648 |
231 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1295807817 CA395353547 |
234 | V>M | No |
ClinGen gnomAD |
|
|
rs1302140641 CA395353733 |
243 | C>Y | No |
ClinGen gnomAD |
|
|
rs1567294084 CA395353819 |
247 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA395353897 rs1202271323 |
251 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA395353956 rs1251276734 |
254 | Q>R | No |
ClinGen gnomAD |
|
|
rs200583282 CA7982527 |
255 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 257 | Q>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 257 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395354178 rs1414023934 |
260 | Y>D | No |
ClinGen gnomAD |
|
|
rs760551737 CA279807901 |
261 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7982543 rs760551737 |
261 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1291380395 CA395354199 |
261 | S>P | No |
ClinGen gnomAD |
|
|
rs902488214 CA279807909 |
267 | T>I | No |
ClinGen TOPMed |
|
|
CA395354469 rs1254572767 |
275 | P>L | No |
ClinGen gnomAD |
|
|
rs144681292 CA7982551 |
278 | N>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA7982550 rs144681292 |
278 | N>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7982556 rs142893579 |
283 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA395354765 rs1461033349 |
286 | A>V | No |
ClinGen gnomAD |
|
|
CA7982558 rs3194168 |
289 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7982559 rs757921346 |
290 | P>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 292 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA279807942 rs201305778 |
294 | K>W | No |
ClinGen TOPMed |
No associated diseases with Q96ES7
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| ATAC complex | A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| SAGA complex | A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
| SAGA-type complex | A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| establishment of protein localization to chromatin | The directed movement of a protein to a part of a chromosome that is organized into chromatin. |
| histone acetylation | The modification of a histone by the addition of an acetyl group. |
| histone H3 acetylation | The modification of histone H3 by the addition of an acetyl group. |
| histone H3-K14 acetylation | The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone. |
| monoubiquitinated histone deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone protein. |
| monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell division | Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. |
| regulation of DNA repair | Any process that modulates the frequency, rate or extent of DNA repair. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of embryonic development | Any process that modulates the frequency, rate or extent of embryonic development. |
| regulation of histone deacetylation | Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. |
| regulation of RNA splicing | Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of tubulin deacetylation | Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALVSADSRI | AELLTELHQL | IKQTQEERSR | SEHNLVNIQK | THERMQTENK | ISPYYRTKLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLYTTAKADA | EAECNILRKA | LDKIAEIKSL | LEERRIAAKI | AGLYNDSEPP | RKTMRRGVLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLLQQSAMTL | PLWIGKPGDK | PPPLCGAIPA | SGDYVARPGD | KVAARVKAVD | GDEQWILAEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSYSHATNKY | EVDDIDEEGK | ERHTLSRRRV | IPLPQWKANP | ETDPEALFQK | EQLVLALYPQ |
| 250 | 260 | 270 | 280 | 290 | |
| TTCFYRALIH | APPQRPQDDY | SVLFEDTSYA | DGYSPPLNVA | QRYVVACKEP | KKK |