AiPD: Autoinhibited Protein Database

Q96C74

Gene name	ROPN1L (ASP, RSPH11)
Protein name	Ropporin-1-like protein
Names	ROPN1-like protein, AKAP-associated sperm protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83853
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-107 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

23-107 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96C74

Entry ID	Method	Resolution	Chain	Position	Source
8J07	EM	410 A	Q/R/q/r	1-230	PDB
AF-Q96C74-F1	Predicted				AlphaFoldDB

209 variants for Q96C74

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359186952 rs1359636885	2	P>Q		No	ClinGen gnomAD
CA359186957 rs1252770395	3	L>F		No	ClinGen gnomAD
CA359186973 rs1395963660	5	D>E		No	ClinGen gnomAD
rs1195710577 CA359186968	5	D>N		No	ClinGen gnomAD
CA359186979 rs1427992436	6	T>S		No	ClinGen gnomAD
rs1168500113 CA359187001	9	C>Y		No	ClinGen gnomAD
TCGA novel	11	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3199592 rs761766011	11	Q>H		No	ClinGen ExAC gnomAD
rs768427973 CA3199591	11	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs768427973 CA3199590	11	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1163898801 CA359187020	12	Q>P		No	ClinGen gnomAD
CA359187030 rs1291889383	13	I>M		No	ClinGen TOPMed
rs772892187 CA3199594	13	I>N		No	ClinGen ExAC
rs1392042947 CA359187047	16	P>A		No	ClinGen gnomAD
rs762533473 CA3199595	16	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA359187050 rs762533473	16	P>R		No	ClinGen ExAC gnomAD
rs766194872 CA3199596	17	P>L		No	ClinGen ExAC gnomAD
CA113906761 rs745877124	17	P>S		No	ClinGen Ensembl
rs1049987928 CA113906772	18	E>G		No	ClinGen TOPMed
rs145970601 CA3199597	18	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA3199598 rs756441351	20	P>R		No	ClinGen ExAC gnomAD
CA359187078 rs764462958	21	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1451360307 CA359187087	23	L>V		No	ClinGen gnomAD
CA3199602 rs575064353	29	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA3199601 rs555236708	29	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1427981422 CA359187143	31	I>T		No	ClinGen TOPMed
rs1159372152 CA359187148	32	R>C		No	ClinGen TOPMed
rs746003458 CA3199603	34	Q>E		No	ClinGen ExAC gnomAD
rs1333113118 CA359187165	35	P>T		No	ClinGen gnomAD
CA3199604 rs368788751	36	A>G		No	ClinGen ESP ExAC gnomAD
TCGA novel	38	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205718057 CA359187198	40	R>L		No	ClinGen TOPMed gnomAD
rs1205718057 CA359187197	40	R>P		No	ClinGen TOPMed gnomAD
rs780256171 CA3199605	40	R>W		No	ClinGen ExAC TOPMed gnomAD
CA3199606 rs371287142	41	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1029984514 CA113906779	41	W>R		No	ClinGen Ensembl
CA3199607 rs768353174	42	S>P		No	ClinGen ExAC gnomAD
CA3199609 rs367925100	43	A>V		No	ClinGen ESP TOPMed gnomAD
CA3199611 rs747868004	44	G>V		No	ClinGen ExAC gnomAD
CA3199642 rs41280363	45	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3199641 rs763405654	45	Y>D		No	ClinGen ExAC gnomAD
rs1268856674 CA359187252	47	S>*		No	ClinGen Ensembl
TCGA novel	47	S>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359187258 rs1285105848 COSM180640	48	A>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1417199572 CA359187256	48	A>P		No	ClinGen TOPMed gnomAD
CA359187269 rs1309412539	50	S>*		No	ClinGen gnomAD
CA359187271 rs1309412539	50	S>L		No	ClinGen gnomAD
CA3199648 rs375461849	52	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs375461849 CA3199649	52	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA359187290 rs1486589153	53	D>E		No	ClinGen gnomAD
rs34537313 CA3199651	55	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA113908649 rs959484664	55	L>P		No	ClinGen Ensembl
CA359187303 rs1479532813	56	P>S		No	ClinGen TOPMed gnomAD
rs1479532813 CA359187301	56	P>T		No	ClinGen TOPMed gnomAD
rs1220600626 CA359187319	58	K>N		No	ClinGen TOPMed
CA3199653 rs771414987	58	K>R		No	ClinGen ExAC gnomAD
rs775218473 CA3199654	59	D>E		No	ClinGen ExAC TOPMed gnomAD
CA113908662 rs992646424	59	D>G		No	ClinGen gnomAD
TCGA novel	59	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs917789209 CA113908669	60	R>K		No	ClinGen Ensembl
CA3199655 rs746611148	62	E>*		No	ClinGen ExAC TOPMed gnomAD
rs1354543661 CA359187353	63	M>I		No	ClinGen gnomAD
rs770171478 CA359187349	63	M>L		No	ClinGen ExAC gnomAD
rs770171478 CA3199656	63	M>V		No	ClinGen ExAC gnomAD
rs773610285 CA3199657	64	P>S		No	ClinGen ExAC TOPMed gnomAD
rs773610285 CA113908674	64	P>T		No	ClinGen ExAC TOPMed gnomAD
CA3199659 rs763285700	65	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1561168812 CA359187365	66	A>T		No	ClinGen Ensembl
CA3199661 rs754049057	67	T>P		No	ClinGen ExAC
CA3199662 rs754049057	67	T>S		No	ClinGen ExAC
CA3199663 rs767438939	68	Q>*		No	ClinGen ExAC gnomAD
rs767438939 CA3199664	68	Q>E		No	ClinGen ExAC gnomAD
CA3199665 rs202000864	71	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs200293869 CA113908689	71	D>H		No	ClinGen Ensembl
CA3199666 rs764389098	72	T>R		No	ClinGen ExAC gnomAD
rs1273422627 CA359187409	73	G>D		No	ClinGen TOPMed
COSM1725936 rs1273422627 CA359187411	73	G>V	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1272185709 CA359187421	75	T>I		No	ClinGen TOPMed gnomAD
rs1272185709 CA359187420	75	T>N		No	ClinGen TOPMed gnomAD
CA359187432 rs1464535741	77	G>R		No	ClinGen TOPMed
TCGA novel	79	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368315797 CA3199669	81	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA359187486 rs1467711139	85	Q>*		No	ClinGen gnomAD
CA359187485 rs1467711139	85	Q>E		No	ClinGen gnomAD
CA3199703 rs548833734	90	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs772513245 CA3199702	90	R>W		No	ClinGen ExAC TOPMed gnomAD
rs760840568 CA3199704 COSM221485	91	Y>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA359187538 rs1294910319	91	Y>H		No	ClinGen gnomAD
CA3199706 rs777012072	92	V>M		No	ClinGen ExAC gnomAD
CA3199707 rs761899366	95	T>I		No	ClinGen ExAC TOPMed gnomAD
rs765465053 CA359187573	96	D>G		No	ClinGen ExAC gnomAD
rs765465053 CA3199708	96	D>V		No	ClinGen ExAC gnomAD
CA359187578 rs1216775071	97	L>F		No	ClinGen gnomAD
CA3199710 rs200409027	100	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1579645352 CA359187618	102	K>R		No	ClinGen Ensembl
VAR_035442 rs35573613 CA113909429	103	N>K		No	ClinGen UniProt TOPMed dbSNP gnomAD
CA3199711 rs762799656	103	N>T		No	ClinGen ExAC gnomAD
CA359187633 CA3199712 rs766373994	104	L>F		No	ClinGen ExAC TOPMed gnomAD
rs373418882 CA3199713	105	C>Y		No	ClinGen ESP ExAC gnomAD
CA3199715 rs145309137	107	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs754500671 CA3199714	107	P>T		No	ClinGen ExAC TOPMed gnomAD
CA359187664 rs1374707768	109	E>D		No	ClinGen gnomAD
rs1039457216 CA113909437	110	K>E		No	ClinGen TOPMed
CA113909443 rs990160865	112	K>E		No	ClinGen Ensembl
CA3199718 rs777460888	112	K>N		No	ClinGen ExAC gnomAD
CA359187687 rs1301242530	113	A>T		No	ClinGen Ensembl
rs2303986 CA3199719 VAR_057789 COSM1264485	113	A>V	oesophagus [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3199721 rs780718485	114	L>F		No	ClinGen ExAC TOPMed gnomAD
CA3199722 rs749195335	117	L>P		No	ClinGen ExAC TOPMed gnomAD
CA359187718 rs1271641999	118	D>Y		No	ClinGen gnomAD
rs986153912 CA113909465	119	P>A		No	ClinGen Ensembl
TCGA novel	119	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373371887 CA3199723	120	C>R		No	ClinGen ESP ExAC gnomAD
CA113909469 rs911892479	122	N>S		No	ClinGen TOPMed
CA359187763 rs1485601585	124	I>T		No	ClinGen gnomAD
COSM735135 CA3199726 rs539771885	126	W>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA3199727 rs769971378	128	N>T		No	ClinGen ExAC gnomAD
CA113909476 rs199968007	131	A>V		No	ClinGen TOPMed gnomAD
CA113909479 rs1002582222	132	L>F		No	ClinGen TOPMed
rs552945189 CA3199729	132	L>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1441785532 CA359187824	133	G>A		No	ClinGen gnomAD
CA3199730 rs766107659	136	M>I		No	ClinGen ExAC gnomAD
CA113909488 rs919116192	138	G>D		No	ClinGen TOPMed gnomAD
rs1394581689 CA359187864	139	G>E		No	ClinGen gnomAD
rs1394581689 COSM326384 CA359187866	139	G>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1411682327 CA359187883	140	S>F		No	ClinGen TOPMed
rs554489516 CA113915095	140	S>T		No	ClinGen TOPMed
CA3199753 rs774173745	142	N>K		No	ClinGen ExAC gnomAD
rs759304695 CA3199754	143	T>A		No	ClinGen ExAC gnomAD
rs1400872643 CA359187901	143	T>S		No	ClinGen gnomAD
CA3199756 rs775431185	144	A>V		No	ClinGen ExAC TOPMed gnomAD
CA359187924 rs1561176400	147	H>P		No	ClinGen Ensembl
CA3199760 rs753462592	149	C>W		No	ClinGen ExAC TOPMed gnomAD
CA3199761 rs764959221	150	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3199763 rs200043905	153	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA359187973 rs183576252	154	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1425768817 CA359187977	155	D>A		No	ClinGen gnomAD
CA359187974 rs1190893461	155	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1190893461 CA359187976	155	D>Y		No	ClinGen gnomAD
rs17851209 CA3199769	156	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs17851209 CA113915161 VAR_035443	156	P>R		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA3199768 rs536955051	156	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3199767 rs536955051	156	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745666898 CA3199771	157	E>G		No	ClinGen ExAC TOPMed gnomAD
CA3199774 rs760619690	159	G>E		No	ClinGen ExAC gnomAD
rs775309425 CA3199773	159	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775309425 CA359187998	159	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3199775 rs763903235	160	P>T		No	ClinGen ExAC gnomAD
rs761391233 CA3199777	161	A>P		No	ClinGen ExAC TOPMed gnomAD
rs761391233 CA359188007	161	A>T		No	ClinGen ExAC TOPMed gnomAD
CA3199779 rs750033423	162	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3199780 rs755410588	162	R>H		No	ClinGen ExAC TOPMed gnomAD
rs755410588 CA3199782	162	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3199781 rs755410588	162	R>P		No	ClinGen ExAC TOPMed gnomAD
rs924000792 CA113915208	166	K>E		No	ClinGen TOPMed gnomAD
CA3199784 rs778119880	166	K>R		No	ClinGen ExAC gnomAD
rs147533644 CA3199785	167	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3199788 rs746039910	168	F>S		No	ClinGen ExAC TOPMed gnomAD
CA359188046 rs1415427324	168	F>V		No	ClinGen gnomAD
CA359188066 rs368430479	171	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs368430479 CA3199790	171	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1432034 rs145787281 CA3199791	173	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs148979217 CA3199792	173	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776702691 CA3199793	174	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs776702691 CA359188086	174	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA3199794 rs761409883	177	R>K		No	ClinGen ExAC gnomAD
rs1385037812 CA359188111	178	L>*		No	ClinGen TOPMed
rs1312856432 CA359188120	179	D>G		No	ClinGen gnomAD
rs1579656175 CA359188153	184	P>H		No	ClinGen Ensembl
TCGA novel	185	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs959794483 CA113915248	186	E>G		No	ClinGen TOPMed gnomAD
rs992537737 CA359188170	187	T>A		No	ClinGen TOPMed gnomAD
CA3199796 rs143784162	187	T>M		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs992537737 CA113915249	187	T>P		No	ClinGen TOPMed gnomAD
CA3199795 rs143784162	187	T>R		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs773025569 CA3199799	188	E>D		No	ClinGen ExAC gnomAD
CA3199800 rs36124677	189	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765917889 CA113915270	190	Y>C		No	ClinGen ExAC gnomAD
CA3199802 rs765917889	190	Y>S		No	ClinGen ExAC gnomAD
rs1431964850 CA359188201	192	A>V		No	ClinGen TOPMed
rs753154460 CA3199803	195	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA113915287 rs942933697	197	N>I		No	ClinGen TOPMed
rs991649485 CA113917514	199	D>G		No	ClinGen Ensembl
CA3199826 rs764314708	199	D>N		No	ClinGen ExAC gnomAD
rs137857729 CA3199829	200	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs137857729 CA3199828	200	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs923436685 CA113917543	202	K>N		No	ClinGen TOPMed gnomAD
rs566464299 CA3199830	203	N>D		No	ClinGen ExAC TOPMed gnomAD
rs566464299 CA113917548	203	N>H		No	ClinGen ExAC TOPMed gnomAD
CA359188287 rs1423597983	204	G>D		No	ClinGen gnomAD
rs566309974 CA113917549	204	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	206	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3199832 rs766626569	206	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1164659703 CA359188333	211	F>V		No	ClinGen TOPMed
COSM1541350 CA359188345 rs1177183015	212	F>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs540931961 CA3199833	213	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1333615586 CA359188367	215	K>N		No	ClinGen gnomAD
rs754827777 CA3199834	216	R>K		No	ClinGen ExAC gnomAD
rs574244668 CA3199835	219	L>I		No	ClinGen 1000Genomes ExAC gnomAD
rs142401850 CA3199836	219	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772777023 CA3199837	221	S>C		No	ClinGen ExAC TOPMed gnomAD
rs1219713472 CA359188404	221	S>T		No	ClinGen gnomAD
CA359188410 rs1272250956	222	I>F		No	ClinGen gnomAD
CA3199838 rs563081436	222	I>N		No	ClinGen 1000Genomes ExAC gnomAD
COSM735131 CA3199839 rs748897594	227	D>Y	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs770280679 CA3199840	228	V>I		No	ClinGen ExAC gnomAD
CA3199841 rs142858482	229	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3199842 rs745468405	230	H>Y		No	ClinGen ExAC gnomAD

No associated diseases with Q96C74

3 regional properties for Q96C74

Type	Name	Position	InterPro Accession
domain	Rap/Ran-GAP domain	1532 - 1766	IPR000331
domain	Tuberin-type domain	556 - 903	IPR018515
domain	Tuberin, N-terminal	54 - 469	IPR024584

Functions

		Description
EC Number
Subcellular Localization	Cell projection, cilium, flagellum Cell projection, cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

1 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.

4 GO annotations of biological process

Name	Definition
epithelial cilium movement involved in extracellular fluid movement	The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
sperm capacitation	A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9HAT0	ROPN1	Ropporin-1A	Homo sapiens (Human)	PR
Q9BZX4	ROPN1B	Ropporin-1B	Homo sapiens (Human)	PR

10	20	30	40	50	60
MPLPDTMFCA	QQIHIPPELP	DILKQFTKAA	IRTQPADVLR	WSAGYFSALS	RGDPLPVKDR
70	80	90	100	110	120
MEMPTATQKT	DTGLTQGLLK	VLHKQCHHKR	YVELTDLEQK	WKNLCLPKEK	FKALLQLDPC
130	140	150	160	170	180
ENKIKWINFL	ALGCSMLGGS	LNTALKHLCE	ILTDDPEGGP	ARIPFKTFSY	VYRYLARLDS
190	200	210	220
DVSPLETESY	LASLKENIDA	RKNGMIGLSD	FFFPKRKLLE	SIENSEDVGH