Q967U1

PR
Gene name
psmE3 (dpr1, DDB_G0285099)
Protein name
Proteasome activator 28
Names
PA28 homolog
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0285099
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q967U1

Entry ID Method Resolution Chain Position Source
AF-Q967U1-F1 Predicted AlphaFoldDB

No variants for Q967U1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q967U1

No associated diseases with Q967U1

1 regional properties for Q967U1

Type Name Position InterPro Accession
domain Proteasome activator PA28, C-terminal domain 80 - 222 IPR003186

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome activator complex A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

1 GO annotations of molecular function

Name Definition
endopeptidase activator activity Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

4 GO annotations of biological process

Name Definition
positive regulation of endopeptidase activity Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
regulation of G1/S transition of mitotic cell cycle Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
regulation of proteasomal protein catabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKNNSTVIK MDEQVLKYKE DLYEKTVHHL KVTIPKKIAE YQELAKSYGQ NSENEQDGQT
70 80 90 100 110 120
SKKRKLDSED YVLMPIEDLI KTNRVIMETH QKFKKAYIEL IETFSVIRGW ISLNIPRIED
130 140 150 160 170 180
GNNFGVDVQE DIITQITKLE EVYTSLLDGS ESYFASRASL VKKILKHKDI EAYRYSLAQV
190 200 210 220
DEKEFTRFSF SYFDLANNYA TTYSLIVKNF AKLETPRPTN ASNIY