Q966W3

PR
Gene name
hst-1 (F08B4.6)
Protein name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Names
Glucosaminyl N-deacetylase/N-sulfotransferase 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F08B4.6
EC number
2.8.2.8: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q966W3

Entry ID Method Resolution Chain Position Source
AF-Q966W3-F1 Predicted AlphaFoldDB

No variants for Q966W3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q966W3

No associated diseases with Q966W3

2 regional properties for Q966W3

Type Name Position InterPro Accession
domain Sulfotransferase domain 583 - 823 IPR000863
domain Heparan sulphate-N-deacetylase 74 - 491 IPR021930

Functions

Description
EC Number 2.8.2.8 Sulfotransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
[heparan sulfate]-glucosamine N-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate
deacetylase activity +Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.

2 GO annotations of biological process

Name Definition
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.
heparin biosynthetic process The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIITPYLNRK ITRPLKWILA LIFLYLIYIC LFSNNSKPPK PRKKPKLVEN YTCPFARTEG
70 80 90 100 110 120
TASENLFFHT NNGTDARILV ILDSLFSRHG KTIIQILNSQ KLQFKAEAVS KNLPVLTTSR
130 140 150 160 170 180
RGRYSLIIIE NYYKYLNMAQ WNRQLLDKYC KEYRVPMFSF MSSKPNDQLK RIKIKGSSLW
190 200 210 220 230 240
MWQNQRIQRL AVTPSIIHRI SKIGNYRQFS SSDPADWILF ETSEKFESVL SGTVKSGYER
250 260 270 280 290 300
AVVVRDKGLE DGVERIIFGR NLTDFQVKIT FLDALWWAMG NQKSFTLDRF VQVDIDDVFV
310 320 330 340 350 360
GAQGTRIVEE DVRKLISTQK EFRNYVQNFT FMLGFSGSYF RNGDDLEDRG DEFLVENAEK
370 380 390 400 410 420
FVWFPHMWRH NHAHEHNFTY LEAIMAQNKL FAQNMHLPVD YPYAIAPQHD GVFPVHEQLF
430 440 450 460 470 480
RAWRKVWNVS VTATEEYPHF KPATARKGFI HAGIHVLPRQ TCGLYTHTQL FDEYPEGFDK
490 500 510 520 530 540
VQKSIEGGDL FFTILLNPIS IFMTHQQNYA YDRLALYTFE NLFRFIKCWT NIKLKWQDPL
550 560 570 580 590 600
TSSQLYFQKF PDERTPLWTN PCTDPRHHAI LPPSINCTKK SLPDLLIIGP QKTGSTALAS
610 620 630 640 650 660
FLSLHPNTSQ NTPVPGSFEE VQFFGGQNYL KGVEWYMSNF PSSSTVTFEK SATYFDNPSA
670 680 690 700 710 720
PKQAASLVPH AKIVIILQNP AQRAYSWFQH ILAHEDPVAI TAGSLEVILD SNSTSSKKVR
730 740 750 760 770 780
QRCISGGRYV HHLTKWLEHF SLQQMIFVDS DELKMKPPTV LNSLSKWLDL PEFPFETYIR
790 800 810 820 830 840
YSPSKGFHCR LLDGKTKCLG ESKGRKYPEM PENLRRKLDK IFSLDNSALY KFLRKNRLKI
850
PTWLEESVRI RA