Q95YM9

PR
Gene name
FGFR
Protein name
Fibroblast growth factor receptor
Names
HrFGFR
Species
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

304-385 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

554-579 (Activation loop from InterPro)

Target domain

382-672 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q95YM9

Entry ID Method Resolution Chain Position Source
AF-Q95YM9-F1 Predicted AlphaFoldDB

No variants for Q95YM9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95YM9

No associated diseases with Q95YM9

12 regional properties for Q95YM9

Type Name Position InterPro Accession
domain Protein kinase domain 382 - 672 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 383 - 668 IPR001245
domain Immunoglobulin subtype 2 89 - 155 IPR003598-1
domain Immunoglobulin subtype 2 186 - 261 IPR003598-2
domain Immunoglobulin subtype 83 - 166 IPR003599-1
domain Immunoglobulin subtype 180 - 272 IPR003599-2
domain Immunoglobulin-like domain 73 - 164 IPR007110-1
domain Immunoglobulin-like domain 173 - 270 IPR007110-2
active_site Tyrosine-protein kinase, active site 533 - 545 IPR008266
domain Immunoglobulin I-set 90 - 165 IPR013098-1
domain Immunoglobulin I-set 180 - 271 IPR013098-2
domain Tyrosine-protein kinase, catalytic domain 382 - 668 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKEFEVKVAS TAFVLVLFSL TINQILASET STKFRSPVPA PTVPDWNHLP NEGNEENVVS
70 80 90 100 110 120
APKQDGASGG QKPYWTKREK MMKRLHAEPA GNTVRFRCAV DGNPKPQVLW YKNDLIVQKN
130 140 150 160 170 180
DRVGGYKYRN QVLILESVVL SDKGNYMCVA RNEYGSINHT YQLDVQERSA SKPILAEGLP
190 200 210 220 230 240
QNKSAYIGDD VTFKCKVYSD AHPHIQWLKS INNHNNAAPN YTVLKAAGVN TTDLDMEVLI
250 260 270 280 290 300
LKNVSFEEAG EYTCLAGNSI GISHQSAWLS VLPVPPPTTD TITKGIPNET NIIIYVMCGV
310 320 330 340 350 360
LVILFGLAVV LVLYYHCYNG KDPPMLVRIE NPDNIPPMTK IEHPTMLFGN TQAWQRMCMP
370 380 390 400 410 420
MQEPFEFNIQ LDLQWELQRE DITLVERLDE GFFGQVFKAD LVTCNNTRKE KMVCAVKMLK
430 440 450 460 470 480
GNRNEKDVLD LLTEMDQMKR VGKHKNIINL LGVCTQNGPL WLVIEYAAQG NLRDYLRRNR
490 500 510 520 530 540
PQNTLCNLVL PSEGRNPDDE LPVPHGDTLT QKDIVSFAFQ VARGLEFLAQ KKCIHRDLAA
550 560 570 580 590 600
RNVLVTEELV MKIADFGLAR DIRSCDYYRK HTRGHLPYKW MALEAMSDNI FTHATDVWSF
610 620 630 640 650 660
GVLLWEIFSL AGSPYPGIKT HELVKFLRSG ERLDKPQYAS QEMYRLMRDC WEEDPSKRPN
670 680 690 700 710 720
FRTLVEDLDR MLAESSTEVY IDFAAGCEAE YSESSEDESE SQNSDEEDDD SVFERMRQID
730 740 750 760
SLSNGNIPFN EEDSSNSDPY VAPLLQNEEN VLQNEHARLR SEA