Q95RV2

PR
Gene name
cav
Protein name
Telomere-binding protein cav
Names
Anonymous fast evolving 1G5, HP1/ORC-associated protein, HOAP p55, Protein caravaggio
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6219
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95RV2

Entry ID Method Resolution Chain Position Source
AF-Q95RV2-F1 Predicted AlphaFoldDB

7 variants for Q95RV2

Variant ID(s) Position Change Description Diseaes Association Provenance
27 K>N strain: NC350 and NC358 [UniProt] No
144 S>T strain: Canton-S [UniProt] No
149 W>C strain: Canton-S [UniProt] No
154 S>T strain: Australia 2, Kenya 38, Kenya 43, Peru and USA 3 [UniProt] No
198 M>I strain: Australia 5 [UniProt] No
236 N>Y strain: Japan [UniProt] No
273 Y>F strain: Australia 5 and USA 1 [UniProt] No

No associated diseases with Q95RV2

2 regional properties for Q95RV2

Type Name Position InterPro Accession
domain Peptidase C12, ubiquitin carboxyl-terminal hydrolase 42 - 275 IPR001578
domain Peptidase C12, C-terminal domain 346 - 391 IPR041507

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Chromosome, telomere
  • Enriched at interphase, polytene and mitotic chromosome telomeres (PubMed:11408576, PubMed:12510197, PubMed:12826664, PubMed:19181850, PubMed:20057353, PubMed:26110638)
  • Localized predominantly at telomeres and diffusely throughout regions of pericentric heterochromatin (PubMed:11408576, PubMed:12510197, PubMed:12826664, PubMed:19181850)
  • Colocalizes with moi/modigliani at telomeres (PubMed:19181850)
  • Telomere localization is not dependent on peo/pendolino, tea, ver/verrocchio or moi/modigliani (PubMed:19181850, PubMed:19240120, PubMed:20679394, PubMed:26110638, PubMed:27835648)
  • Telomere localization is enhanced by, but not dependent on, Su(var)205/HP1 (PubMed:12510197)
  • Telomere localization is enhanced by the activity of tefu/ATM and the MRN complex (PubMed:20057353)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.

1 GO annotations of molecular function

Name Definition
telomeric DNA binding Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.

2 GO annotations of biological process

Name Definition
telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLLLCVNMS GTQMSAFLRK YLADEDKKIR AQFKESDPNN KLILWMHEKT RITEEDLARP
70 80 90 100 110 120
YTEDEVKELC LRTKVKVDMT AWNCLWEAKK RFEAKGRFVN KSERFINRMY MKAVRRKMVQ
130 140 150 160 170 180
PYPEEFVAQR REIVAAETKK QNISRLDRWQ KKKSQNLSAP ESSPDAHASS NDAVQSHEDQ
190 200 210 220 230 240
ANTNLSSLSQ MNFQVEAMAP PGVSSSDLSG IGDDEDEQQQ SGFQDENINR PETEINENSV
250 260 270 280 290 300
RCDPINLGRM RTGCINSQAN NSFRNTESDP DYYMFGTQLS TLVRPTSTQE PDDQVNCPET
310 320 330 340
EMNESWVRCD QINSESLSIG PSIDSEGTIT FQNTESEPID VTSIA