Q95RA8

SS
Gene name
mats (CG13852)
Protein name
MOB kinase activator-like 1
Names
Mob as tumor suppressor protein 1 , Dmob1 , Mps one binder kinase activator-like 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
dme:Dmel_CG13852
EC number
Protein Class

Descriptions

Myocardin (MYOCD) is a transcriptional co-activator that promotes cardiac or smooth muscle gene programs through its interaction with myocyte-enhancing factor (MEF2) or serum-response factor (SRF). Isoforms of MYOCD with a truncated amino terminus show increased activity when compared with those with the full-length amino terminus. The cardiac-specific amino terminus acted in an autoinhibitory fashion to bind MYOCD via specific negatively charged residues and thereby repressed SRF-dependent MYOCD activity. Deletion of N-terminal MDH domain or mutagenesis of the residues within the domain disrupts autoinhibition.

Autoinhibitory domains (AIDs)

1-38 (N-terminal extension including the Switch helix) SS

Target domain

41-204 (MH domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95RA8

Entry ID Method Resolution Chain Position Source
AF-Q95RA8-F1 Predicted AlphaFoldDB

No variants for Q95RA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95RA8

No associated diseases with Q95RA8

5 regional properties for Q95RA8

Type Name Position InterPro Accession
conserved_site Helix-turn-helix motif 124 - 149 IPR000047
domain Homeobox domain 93 - 157 IPR001356
conserved_site Homeobox, conserved site 128 - 151 IPR017970
domain Homeobox domain, metazoa 117 - 128 IPR020479-1
domain Homeobox domain, metazoa 132 - 151 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

8 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
follicle cell of egg chamber development The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P43563 MOB2 CBK1 kinase activator protein MOB2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P40484 MOB1 DBF2 kinase activator protein MOB1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q9H8S9 MOB1A MOB kinase activator 1A Homo sapiens (Human) EV
Q7L9L4 MOB1B MOB kinase activator 1B Homo sapiens (Human) SS
Q8BPB0 Mob1b MOB kinase activator 1B Mus musculus (Mouse) EV
Q921Y0 Mob1a MOB kinase activator 1A Mus musculus (Mouse) SS
Q3T1J9 Mob1a MOB kinase activator 1A Rattus norvegicus (Rat) SS
Q8GYX0 MOB1B MOB kinase activator-like 1B Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHI1 MOB1A MOB kinase activator-like 1A Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MTLLGSEHSL LIRRKFRSVL QLRLQQRRTQ EQLANQGLIP PLKSPTEFHD PRKKLDSAKT
70 80 90 100 110 120
EDSLRRKVRN RSDRASLVNM HILQASTAER SIPTAQMKLK RARLADDLNE KIALRPGPLE
130 140 150 160 170 180
LVEKNILPMD SSVKEAIKGT EVSLSKAADA FAFEDDSSRD GLSPDQARSE DPQGSGGSTP
190 200 210 220 230 240
DIKSTEAPLA GPLDTIQDLT PGSESDKNDT ASQLSNQSDS GKQVLGPLST PIPVHTAVKS
250 260 270 280 290 300
KSLGDSKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ
310 320 330 340 350 360
ILSQQQQQQQ QQQQQQQQQQ QQQRFSYPGM HQAHLKEPNE QMTRNPNSSS TPLNNTPLSP
370 380 390 400 410 420
VKNSLSGQTG VSSLKPGPLP PNLDDLKVSE LRQQLRIRGL PVSGTKTALV DRLRPFQDCA
430 440 450 460 470 480
GNPVPNFGDI TTVTFPVTPN TLPSYQSSPS GFYHFGSTSS SPPISPASSD LSAAGSLPDT
490 500 510 520 530 540
FTDASPGFGL HASPVPACTD ESLLSSLNGG SGPSEPDGLD SEKDKMLVEK QKVINQLTWK
550 560 570 580 590 600
LRQEQRQVEE LRMQLQKQKS GCNDQKPLPF LATTIKQEDV SSCPFAAQQA SGKGQGHSSD
610 620 630 640 650 660
SPPPACETAQ LLPHCVESSG QTHVLSSTFL SPQCSPQHSP LGTLKSPQHI SLPPSPNNHY
670 680 690 700 710 720
FLASSSGAQR ENHGVSSPNS SQGCAQMTGL QSSDKVGPTF SIPSPTFPKS SPTVPEITQP
730 740 750 760 770 780
PSYEDAVKQQ MTRSQQMDEL LDVLIESGEM PADAREDHSC LQKIPKIPGS SCSPTTILPK
790 800 810 820 830 840
SSASFEQASS GGQISFDHYA TDSEEHLEVL LNSHSPIGKV SDVTLLKIGS EEPPFDGIMD
850 860 870 880 890 900
GFPGKAAEDL FSAHELLPGP LSPMHTQLSP PSVDSSGLQL SFTESPWETM EWLDLTPPSS
910 920 930
TPGFSNLTSS GPSIFNIDFL DVTDLNLNSP MDLHLQQW