Q95NQ0

PR
Gene name
mth2
Protein name
G-protein coupled receptor Mth2
Names
Protein methuselah-2
Species
Drosophila simulans (Fruit fly)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

370-441 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95NQ0

Entry ID Method Resolution Chain Position Source
AF-Q95NQ0-F1 Predicted AlphaFoldDB

1 variants for Q95NQ0

Variant ID(s) Position Change Description Diseaes Association Provenance
127 F>L strain: ct96_6.1s, hfl97_4.1s, ga96_2.1s and va96_8.1s [UniProt] No

No associated diseases with Q95NQ0

2 regional properties for Q95NQ0

Type Name Position InterPro Accession
domain Methuselah, N-terminal domain 17 - 197 IPR010596
domain GPCR, family 2-like, transmembrane domain 206 - 473 IPR017981

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

1 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAERDHYHTI DDPNVPCNFY DTVNLTGHRL FPNGSYDYYG TIVPAELVGT YDYIHSSLTE
70 80 90 100 110 120
RIEVREHVRG CVCKFKSCLN ICCPWRQVFN SEVDGCIIDH TDNRTWPDPP MLNITFRNES
130 140 150 160 170 180
TILVNMFTQF AIQSFRPCPK MFSLQPETSS WDDYLLFENG SMLRVDDKLL IRKNEFCMVP
190 200 210 220 230 240
TYVNESDMFY TIHPANCDMQ DDHSTVKIIN SYAMMFSIPF MMLTIAVYLL IPELRNQHGK
250 260 270 280 290 300
SLVCYLIGLT VGYSSLCYVQ LYQVDATGVT CKVFGYTAYF FFMGAYMWLS VISFDLWHNF
310 320 330 340 350 360
RGTRGINRFQ EKKRFLFYSL YSWGIALVFL AFTYCAQQLS NLPDNLKPGI GDGVYCWLDM
370 380 390 400 410 420
SNWAAMIYFY GPILAIVVAN TIMFIMTAIK IHGVQREMAR IIASENSTKN LRTEKDKFGL
430 440 450 460 470 480
FLRLFLIMGI TWLTELISYF VGSDKGWSKL FYISDLANAM QGFLIFMLFV MKKKVKHLIT
490 500 510 520 530
NRCSSVRDGS NQRQSQYSTK TTSSSVANLS LHEKPSVEKP LVISSSVDPQ KTTIFR